HitPredict

Interactor 1: NTRK1 (P04629)
High affinity nerve growth factor receptor (EC 2.7.10.1) (Neurotrophic tyrosine kinase receptor type 1) (TRK1-transforming tyrosine kinase protein) (Tropomyosin-related kinase A) (Tyrosine kinase receptor) (Tyrosine kinase receptor A) (Trk-A) (gp140trk) (p140-TrkA)
Gene: NTRK1

Interactor 2: FKBP5 (Q13451)
Peptidyl-prolyl cis-trans isomerase FKBP5 (PPIase FKBP5) (EC 5.2.1.8) (51 kDa FK506-binding protein) (51 kDa FKBP) (FKBP-51) (54 kDa progesterone receptor-associated immunophilin) (Androgen-regulated protein 6) (FF1 antigen) (FK506-binding protein 5) (FKBP-5) (FKBP54) (p54) (HSP90-binding immunophilin) (Rotamase)
Gene: FKBP5

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.56	0.80	0.675

Property	Details
Experiments	25921289, 35384245
Identification Methods	affinity chromatography technology, proximity labelling technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	FKBP_C~PK_Tyr_Ser-Thr
Common GO terms	-
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 796 Hs			1 457
+	Hs
		384676 NTRK1_HUMAN (1-796): 0: 621: 100.00		FKBP4_HUMAN (1-456): 1.79e-136: 402: 54.59
+	Hs
		384721 NTRK1_HUMAN (1-796): 0: 621: 100.00		PPID_HUMAN (249-414): 4.11e-51: 178: 24.55
+	Hs
		118668 NTRK1_HUMAN (1-796): 0: 621: 100.00		AIP_HUMAN (144-414): 1.52e-49: 173: 16.72
+	Hs
		384834 NTRK1_HUMAN (1-796): 0: 621: 100.00		FKBP8_HUMAN (25-330): 3.36e-27: 114: 19.23
+	Hs
		384359 NTRK1_HUMAN (1-796): 0: 621: 100.00		STIP1_HUMAN (265-457): 3.91e-23: 104: 17.62
+	Hs
		118739 NTRK2_HUMAN (12-796): 1.28e-176: 529: 46.72		AIP_HUMAN (144-414): 1.52e-49: 173: 16.72
+	Hs
		118690 FGFR4_HUMAN (140-795): 7.96e-168: 506: 25.59		AIP_HUMAN (144-414): 1.52e-49: 173: 16.72
+	Hs
		537736 INSRR_HUMAN (493-782): 6.64e-66: 241: 42.91		FKBP5_HUMAN (1-457): 6.63e-145: 423: 100.00
+	Hs
		972518 DDR2_HUMAN (499-781): 3.37e-72: 254: 44.55		FKBP4_HUMAN (1-456): 1.79e-136: 402: 54.59
+	Hs
		118691 FGFR3_HUMAN (168-794): 3.98e-158: 481: 25.98		AIP_HUMAN (144-414): 1.52e-49: 173: 16.72
+	Hs
		118676 RET_HUMAN (391-794): 3.5e-114: 374: 30.44		AIP_HUMAN (144-414): 1.52e-49: 173: 16.72
+	Hs
		118724 DDR1_HUMAN (507-778): 1.77e-67: 242: 45.49		AIP_HUMAN (144-414): 1.52e-49: 173: 16.72
+	Hs
		118686 INSRR_HUMAN (493-782): 6.64e-66: 241: 42.91		AIP_HUMAN (144-414): 1.52e-49: 173: 16.72
+	Hs
		118696 LTK_HUMAN (502-790): 3.09e-60: 221: 41.64		AIP_HUMAN (144-414): 1.52e-49: 173: 16.72
+	Hs
		1052994 DDR2_HUMAN (499-781): 3.37e-72: 254: 44.55		FKBP8_HUMAN (25-330): 3.36e-27: 114: 19.23
+	Hs
		537740 INSRR_HUMAN (493-782): 6.64e-66: 241: 42.91		FKBP8_HUMAN (25-330): 3.36e-27: 114: 19.23
+	Rn
		193482 INSR_RAT (493-777): 7.31e-66: 241: 41.95		STIP1_RAT (265-457): 1.25e-22: 102: 18.14
+	Hs
		435726 IGF1R_HUMAN (493-777): 6.97e-71: 255: 42.61		FKB10_HUMAN (134-285): 5.25e-13: 72.9: 20.51
+	Hs
		411467 INSR_HUMAN (493-777): 3e-68: 248: 42.62		FKB10_HUMAN (134-285): 5.25e-13: 72.9: 20.51
+	At
		1341059 BRL2_ARATH (140-396): 2.09e-17: 89.3: 10.49		FK201_ARATH (22-135): 1.12e-22: 96.7: 47.01