HitPredict

Interactor 1: NTRK1 (P04629)
High affinity nerve growth factor receptor (EC 2.7.10.1) (Neurotrophic tyrosine kinase receptor type 1) (TRK1-transforming tyrosine kinase protein) (Tropomyosin-related kinase A) (Tyrosine kinase receptor) (Tyrosine kinase receptor A) (Trk-A) (gp140trk) (p140-TrkA)
Gene: NTRK1

Interactor 2: GRDN (Q3V6T2)
Girdin (Akt phosphorylation enhancer) (APE) (Coiled-coil domain-containing protein 88A) (G alpha-interacting vesicle-associated protein) (GIV) (Girders of actin filament) (Hook-related protein 1) (HkRP1)
Gene: CCDC88A

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	0.60	0.479

Property	Details
Experiments	25921289
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005886 - plasma membrane GO:0042803 - protein homodimerization activity
Homologous interactions	19

Homologous interactions

Color coding for hit scores

	1 796 Hs			1 1871
+	Hs
		508036 FGFR1_HUMAN (195-794): 0: 545: 26.34		GRDN_HUMAN (1-1871): 2.19e-149: 509: 100.00
+	Hs
		1083852 NTRK2_HUMAN (12-796): 1.28e-176: 529: 46.72		GRDN_HUMAN (1-1871): 2.19e-149: 509: 100.00
+	Hs
		601523 FGFR2_HUMAN (87-794): 5.67e-159: 484: 22.55		GRDN_HUMAN (1-1871): 2.19e-149: 509: 100.00
+	Hs
		411404 INSR_HUMAN (493-777): 3e-68: 248: 42.62		GRDN_HUMAN (1-1871): 2.19e-149: 509: 100.00
+	Hs
		384384 NTRK1_HUMAN (1-796): 0: 621: 100.00		MYH9_HUMAN (1-809): 2.13e-29: 130: 10.02
+	Hs
		666610 LTK_HUMAN (502-790): 3.09e-60: 221: 41.64		GRDN_HUMAN (1-1871): 2.19e-149: 509: 100.00
+	Hs
		384385 NTRK1_HUMAN (1-796): 0: 621: 100.00		MYH10_HUMAN (43-620): 1.66e-20: 101: 9.86
+	Hs
		384180 NTRK1_HUMAN (1-796): 0: 621: 100.00		TPR_HUMAN (1125-1868): 4.51e-19: 97: 12.93
+	Hs
		385106 NTRK1_HUMAN (1-796): 0: 621: 100.00		HOOK3_HUMAN (14-554): 1.3e-16: 88.2: 23.48
+	Hs
		384210 NTRK1_HUMAN (1-796): 0: 621: 100.00		DESP_HUMAN (244-1208): 1.11e-09: 66.2: 19.09
+	Hs
		254431 NTRK1_HUMAN (1-796): 0: 621: 100.00		ROCK2_HUMAN (244-1010): 3.06e-09: 64.3: 20.76
+	Hs
		254442 FGFR1_HUMAN (195-794): 0: 545: 26.34		ROCK2_HUMAN (244-1010): 3.06e-09: 64.3: 20.76
+	Hs
		609584 FGFR3_HUMAN (168-794): 3.98e-158: 481: 25.98		DAPLE_HUMAN (862-1846): 6.94e-26: 119: 11.33
+	Hs
		518818 FGFR3_HUMAN (168-794): 3.98e-158: 481: 25.98		TPR_HUMAN (1125-1868): 4.51e-19: 97: 12.93
+	Hs
		665375 EPHA3_HUMAN (262-788): 8.75e-112: 365: 26.64		MYH9_HUMAN (1-809): 2.13e-29: 130: 10.02
+	Hs
		725069 ALK_HUMAN (505-790): 8.72e-63: 231: 42.07		MYH9_HUMAN (1-809): 2.13e-29: 130: 10.02
+	Hs
		725268 ALK_HUMAN (505-790): 8.72e-63: 231: 42.07		MYH10_HUMAN (43-620): 1.66e-20: 101: 9.86
+	Rn
		94275 INSR_RAT (493-777): 7.31e-66: 241: 41.95		F1LUA1_RAT (55-519): 2.12e-10: 68.4: 11.23
+	Hs
		828639 ALK_HUMAN (505-790): 8.72e-63: 231: 42.07		CENPF_HUMAN (249-1186): 2.54e-10: 68.2: 21.17