Protein: HSP27
Heat shock protein 27

Gene: HSP27
Organism: Drosophila melanogaster
Interactions: 62
UniProt ID: P02518

Gene Ontology (top 5):
GO:0005634 - nucleus
GO:0005737 - cytoplasm
GO:0008340 - determination of adult lifespan
GO:0009408 - response to heat
GO:0034663 - endoplasmic reticulum chaperone complex

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

384757

HSP22
Heat shock protein 22

2

18

High-throughput

0.737

High

384791

HSP23
Heat shock protein 23

2

17

High-throughput

0.737

High

384884

HSP26
Heat shock protein 26

2

19

High-throughput

0.737

High

384973

HSP27
Heat shock protein 27

1

19

Small-scale

0.647

High

57710

A1ZB73
Glutathione S transferase E8, isoform A

2

5

High-throughput

0.571

High

356610

HSP68
Heat shock protein 68

2

17

High-throughput

0.571

High

384975

REF2P
Protein ref(2)P

2

3

High-throughput

0.571

High

384998

Q8MS69
tRNA

2

2

High-throughput

0.571

High

384989

Q7KNM2
Dorsal interacting protein 4

1

6

Small-scale

0.552

High

384986

Q7JVW5
LD44919p

2

7

High-throughput

0.521

High

384988

Q7KMQ0
26S proteasome regulatory subunit 7

2

4

High-throughput

0.521

High

384985

Q5BI03
LD02690p

1

4

High-throughput

0.508

High

385002

Q9V472
DLim1

1

4

High-throughput

0.508

High

385008

Q9VGI4
non-specific serine/threonine protein kinase

1

10

High-throughput

0.508

High

384981

EAS
Ethanolamine kinase

1

0

High-throughput

0.486

High

384993

TAD2B
Transcriptional adapter 2b

1

0

High-throughput

0.486

High

95374

E1JJ76
Alhambra, isoform H

1

4

High-throughput

0.481

High

384979

SUV39
Histone-lysine N-methyltransferase Su(var)3-9

1

5

High-throughput

0.481

High

384974

HSP71
Major heat shock 70 kDa protein Ab

1

17

High-throughput

0.479

High

384976

RS27A
Ubiquitin-ribosomal protein eS31 fusion protein [Cleaved into: Ubiquitin; Small ribosomal subunit protein eS31

1

6

Small-scale

0.479

High

384977

DDX6
ATP-dependent RNA helicase me31b

1

3

High-throughput

0.479

High

384978

EZ
Histone-lysine N-methyltransferase E(z)

1

3

Small-scale

0.479

High

384995

HSP72
Major heat shock 70 kDa protein Ba

1

17

High-throughput

0.479

High

384999

Q8SWW7
LD26392p

1

10

High-throughput

0.479

High

385000

Q9N6D8
GH11591p

1

5

Small-scale

0.479

High

385001

Q9V3V6
26S proteasome regulatory complex subunit p50

1

4

Small-scale

0.479

High

385019

PYRG
CTP synthase

1

1

High-throughput

0.479

High

384990

LIS1
Lissencephaly-1 homolog

1

2

High-throughput

0.464

High

385021

MED19
Mediator of RNA polymerase II transcription subunit 19

1

2

High-throughput

0.464

High

385022

Q9VVQ1
Allatostatin C receptor 1

1

2

High-throughput

0.464

High

385004

Q9VDS3
Exit protein of rhodopsin and TRP A

1

0

Small-scale

0.458

High

385010

Q9VI63
AF10

1

2

High-throughput

0.457

High

384980

HYD
E3 ubiquitin-protein ligase hyd

1

6

High-throughput

0.445

High

384983

HSP70
Major heat shock 70 kDa protein Aa

1

17

High-throughput

0.445

High

385006

HSP74
Major heat shock 70 kDa protein Bbb

1

17

High-throughput

0.445

High

385015

Q9VNC2
Histone deacetylase

1

3

High-throughput

0.445

High

385023

PSA6
Proteasome subunit alpha type-6

1

1

High-throughput

0.445

High

385024

EAF3
NuA4 complex subunit EAF3 homolog

1

3

High-throughput

0.445

High

54245

A1Z8D5
FI20187p1

1

4

High-throughput

0.437

High

120594

M9PDN0
Uncharacterized protein, isoform C

1

5

High-throughput

0.437

High

384982

CNN
Centrosomin

1

11

Small-scale

0.437

High

384984

Q0E924
Prohibitin

1

5

High-throughput

0.437

High

385005

Q9VEV3
Tetratricopeptide repeat protein 1

1

6

High-throughput

0.437

High

385014

ZUC
Mitochondrial cardiolipin hydrolase

1

1

High-throughput

0.437

High

385016

TGT
Queuine tRNA-ribosyltransferase catalytic subunit

1

5

High-throughput

0.437

High

385018

QTRT2
Queuine tRNA-ribosyltransferase accessory subunit 2

1

5

High-throughput

0.437

High

385003

VRET
Protein vreteno

1

0

Small-scale

0.426

High

385007

Q9VGB9
trypsin

1

3

High-throughput

0.417

High

54233

A1Z8D4
AT13868p

1

4

High-throughput

0.407

High

384991

Q7KT86
IP11188p

1

7

High-throughput

0.407

High

384992

Q86BQ2
IP08413p

1

5

High-throughput

0.407

High

384997

Q8MQY0
SD02058p

1

2

High-throughput

0.407

High

385009

Q9VGJ4
sn-1-specific diacylglycerol lipase ABHD11

1

3

High-throughput

0.407

High

385012

Q9VIT9
TEP1-F

1

3

High-throughput

0.407

High

385013

Q9VJZ5
LD07294p

1

3

High-throughput

0.407

High

385017

Q9VRA0
Migration and invasion enhancer 1

1

3

High-throughput

0.407

High

385020

Q9VUQ1
RE70822p

1

3

High-throughput

0.407

High

384994

Q8IMJ2
Uncharacterized protein

1

0

High-throughput

0.265

Low

385011

Q9VIE7
GMP synthase

1

0

High-throughput

0.265

Low

384996

Q8IRH9
FI21268p1

1

0

High-throughput

0.238

Low

384987

Q7K4P0
LD30408p

1

0

High-throughput

0.232

Low


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Last updated: 11Aug2025