HitPredict

Interactor 1: NTRK1 (P04629)
High affinity nerve growth factor receptor (EC 2.7.10.1) (Neurotrophic tyrosine kinase receptor type 1) (TRK1-transforming tyrosine kinase protein) (Tropomyosin-related kinase A) (Tyrosine kinase receptor) (Tyrosine kinase receptor A) (Trk-A) (gp140trk) (p140-TrkA)
Gene: NTRK1

Interactor 2: DHB12 (Q53GQ0)
Very-long-chain 3-oxoacyl-CoA reductase (EC 1.1.1.330) (17-beta-hydroxysteroid dehydrogenase 12) (17-beta-HSD 12) (3-ketoacyl-CoA reductase) (KAR) (Estradiol 17-beta-dehydrogenase 12) (EC 1.1.1.62) (Short chain dehydrogenase/reductase family 12C member 1)
Gene: HSD17B12

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.58	0.50	0.543

Property	Details
Experiments	25921289, 35384245
Identification Methods	affinity chromatography technology
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	-
Homologous interactions	8

Homologous interactions

Color coding for hit scores

	1 796 Hs			1 312
+	Hs
		384940 NTRK1_HUMAN (1-796): 0: 621: 100.00		HSDL1_HUMAN (3-310): 1.13e-74: 234: 39.24
+	Hs
		385176 NTRK1_HUMAN (1-796): 0: 621: 100.00		DHB11_HUMAN (29-256): 1.18e-62: 202: 29.06
+	Hs
		1081501 NTRK3_HUMAN (36-796): 1.63e-174: 525: 49.37		DHB12_HUMAN (1-312): 4.67e-98: 292: 100.00
+	Hs
		609330 FGFR3_HUMAN (168-794): 3.98e-158: 481: 25.98		DHB12_HUMAN (1-312): 4.67e-98: 292: 100.00
+	Hs
		435661 IGF1R_HUMAN (493-777): 6.97e-71: 255: 42.61		DHB12_HUMAN (1-312): 4.67e-98: 292: 100.00
+	Hs
		1121036 ALK_HUMAN (505-790): 8.72e-63: 231: 42.07		DHB12_HUMAN (1-312): 4.67e-98: 292: 100.00
+	Rn
		88679 INSR_RAT (493-777): 7.31e-66: 241: 41.95		D3ZPU3_RAT (1-312): 4.67e-89: 270: 78.85
+	Rn
		544934 INSR_RAT (493-777): 7.31e-66: 241: 41.95		PECR_RAT (38-300): 2.51e-71: 224: 19.33