HitPredict

Interactor 1: NTRK1 (P04629)
High affinity nerve growth factor receptor (EC 2.7.10.1) (Neurotrophic tyrosine kinase receptor type 1) (TRK1-transforming tyrosine kinase protein) (Tropomyosin-related kinase A) (Tyrosine kinase receptor) (Tyrosine kinase receptor A) (Trk-A) (gp140trk) (p140-TrkA)
Gene: NTRK1

Interactor 2: MED12 (Q93074)
Mediator of RNA polymerase II transcription subunit 12 (Activator-recruited cofactor 240 kDa component) (ARC240) (CAG repeat protein 45) (Mediator complex subunit 12) (OPA-containing protein) (Thyroid hormone receptor-associated protein complex 230 kDa component) (Trap230) (Trinucleotide repeat-containing gene 11 protein)
Gene: MED12

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	0.50	0.437

Property	Details
Experiments	25921289
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	-
Homologous interactions	18

Homologous interactions

Color coding for hit scores

	1 796 Hs			1 2177
+	Hs
		385047 NTRK1_HUMAN (1-796): 0: 621: 100.00		CRACD_HUMAN (1744-2168): 6.51e-13: 76.8: 16.78
+	Hs
		302238 NTRK1_HUMAN (1-796): 0: 621: 100.00		SC31A_HUMAN (1897-2176): 1.29e-11: 72.3: 11.54
+	Hs
		385411 NTRK1_HUMAN (1-796): 0: 621: 100.00		ATX2_HUMAN (1645-2176): 2.64e-11: 71.5: 9.32
+	Hs
		302247 FGFR1_HUMAN (195-794): 0: 545: 26.34		SC31A_HUMAN (1897-2176): 1.29e-11: 72.3: 11.54
+	Hs
		508132 FGFR1_HUMAN (195-794): 0: 545: 26.34		CBP_HUMAN (1582-2176): 2.69e-11: 71.5: 13.45
+	Rn
		94375 FGFR1_RAT (195-794): 6.12e-180: 538: 26.34		F1M9G7_RAT (1694-2031): 6.55e-10: 66.9: 9.47
+	Hs
		302291 NTRK3_HUMAN (36-796): 1.63e-174: 525: 49.37		SC31A_HUMAN (1897-2176): 1.29e-11: 72.3: 11.54
+	Hs
		302255 FGFR4_HUMAN (140-795): 7.96e-168: 506: 25.59		SC31A_HUMAN (1897-2176): 1.29e-11: 72.3: 11.54
+	Hs
		358598 FGFR3_HUMAN (168-794): 3.98e-158: 481: 25.98		CO2A1_HUMAN (1603-2086): 2.19e-14: 81.5: 11.42
+	Hs
		302241 RET_HUMAN (391-794): 3.5e-114: 374: 30.44		SC31A_HUMAN (1897-2176): 1.29e-11: 72.3: 11.54
+	Hs
		300529 EPHA3_HUMAN (262-788): 8.75e-112: 365: 26.64		NFAT5_HUMAN (1583-2168): 1.04e-12: 76.1: 12.29
+	Rn
		94082 INSR_RAT (493-777): 7.31e-66: 241: 41.95		F1LRM7_RAT (1668-2168): 9.55e-18: 92.7: 9.63
+	Rn
		88517 INSR_RAT (493-777): 7.31e-66: 241: 41.95		D3ZAP7_RAT (1552-1981): 8.23e-17: 90: 8.05
+	Hs
		302242 IGF1R_HUMAN (493-777): 6.97e-71: 255: 42.61		SC31A_HUMAN (1897-2176): 1.29e-11: 72.3: 11.54
+	Rn
		102464 INSR_RAT (493-777): 7.31e-66: 241: 41.95		G3V699_RAT (1876-2174): 1.27e-11: 72.7: 11.51
+	Rn
		94371 INSR_RAT (493-777): 7.31e-66: 241: 41.95		F1M9G7_RAT (1694-2031): 6.55e-10: 66.9: 9.47
+	Hs
		302332 ALK_HUMAN (505-790): 8.72e-63: 231: 42.07		SC31A_HUMAN (1897-2176): 1.29e-11: 72.3: 11.54
+	Hs
		169154 MUSK_HUMAN (171-374): 2.86e-13: 75.8: 18.61		SC31A_HUMAN (1897-2176): 1.29e-11: 72.3: 11.54