Protein: K2C6B
Keratin, type II cytoskeletal 6B (Cytokeratin-6B) (CK-6B) (Keratin-6B) (K6B) (Type-II keratin Kb10)

Gene: K2C6B, KRT6B
Organism: Homo sapiens
Interactions: 150
UniProt ID: P04259

Gene Ontology (top 5):
GO:0005200 - structural constituent of cytoskeleton
GO:0005829 - cytosol
GO:0007398 - ectoderm development
GO:0030280 - structural constituent of skin epidermis
GO:0031424 - keratinization

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

407251

K1C15
Keratin, type I cytoskeletal 15

5

20

High-throughput

0.933

High

407240

K1C19
Keratin, type I cytoskeletal 19

4

20

High-throughput

0.896

High

300716

KRT38
Keratin, type I cuticular Ha8

3

20

High-throughput

0.875

High

407295

K1H1
Keratin, type I cuticular Ha1

3

20

High-throughput

0.871

High

407246

K1C13
Keratin, type I cytoskeletal 13

3

20

High-throughput

0.845

High

300618

KRT37
Keratin, type I cuticular Ha7

2

20

High-throughput

0.783

High

407289

KT33B
Keratin, type I cuticular Ha3-II

2

20

High-throughput

0.783

High

407305

K1C40
Keratin, type I cytoskeletal 40

2

20

High-throughput

0.783

High

407306

K1C39
Keratin, type I cytoskeletal 39

2

20

High-throughput

0.783

High

407311

K1C28
Keratin, type I cytoskeletal 28

2

20

High-throughput

0.783

High

407312

K1C27
Keratin, type I cytoskeletal 27

2

20

High-throughput

0.783

High

407314

K1C25
Keratin, type I cytoskeletal 25

2

20

High-throughput

0.783

High

407323

KRT35
Keratin, type I cuticular Ha5

2

20

High-throughput

0.783

High

407242

K1C16
Keratin, type I cytoskeletal 16

2

20

High-throughput

0.757

High

407335

KIFC3
Kinesin-like protein KIFC3

3

9

High-throughput

0.675

High

300542

KRT36
Keratin, type I cuticular Ha6

1

20

High-throughput

0.621

High

407290

K1H2
Keratin, type I cuticular Ha2

1

20

High-throughput

0.621

High

407298

K1C24
Keratin, type I cytoskeletal 24

1

20

High-throughput

0.621

High

407313

K1C26
Keratin, type I cytoskeletal 26

1

20

High-throughput

0.621

High

407276

UBE3A
Ubiquitin-protein ligase E3A

2

4

Small-scale

0.619

High

341721

K2C75
Keratin, type II cytoskeletal 75

1

20

High-throughput

0.618

High

385031

K1C14
Keratin, type I cytoskeletal 14

1

20

High-throughput

0.618

High

385214

K2C6A
Keratin, type II cytoskeletal 6A

1

20

High-throughput

0.618

High

407236

K1C18
Keratin, type I cytoskeletal 18

1

20

High-throughput

0.618

High

407237

K2C8
Keratin, type II cytoskeletal 8

1

20

High-throughput

0.618

High

407239

VIME
Vimentin

1

20

High-throughput

0.618

High

407241

K2C7
Keratin, type II cytoskeletal 7

1

20

High-throughput

0.618

High

407245

K1C10
Keratin, type I cytoskeletal 10

1

20

High-throughput

0.618

High

407247

K2C5
Keratin, type II cytoskeletal 5

1

20

High-throughput

0.618

High

407249

DESM
Desmin

1

20

High-throughput

0.618

High

407255

K1C20
Keratin, type I cytoskeletal 20

1

20

High-throughput

0.618

High

407258

PERI
Peripherin

1

20

High-throughput

0.618

High

407275

K1C17
Keratin, type I cytoskeletal 17

1

20

High-throughput

0.618

High

407333

K1C12
Keratin, type I cytoskeletal 12

1

20

High-throughput

0.618

High

407346

KRT84
Keratin, type II cuticular Hb4

1

20

High-throughput

0.618

High

407339

TRI54
Tripartite motif-containing protein 54

3

20

High-throughput

0.616

High

407348

TFP11
Tuftelin-interacting protein 11

3

4

High-throughput

0.616

High

407351

GCP4
Gamma-tubulin complex component 4

2

1

High-throughput

0.606

High

49877

A1A4E9
Keratin 13

1

20

High-throughput

0.594

High

163888

NDC80
Kinetochore protein NDC80 homolog

1

20

High-throughput

0.573

High

217038

MS18B
Protein Mis18-beta

2

6

High-throughput

0.553

High

407256

NUP62
Nuclear pore glycoprotein p62

2

5

High-throughput

0.553

High

389917

ALBU
Albumin

1

3

High-throughput

0.536

High

407285

CUL1
Cullin-1

1

20

High-throughput

0.536

High

407286

CUL3
Cullin-3

1

20

High-throughput

0.536

High

407315

CAND1
Cullin-associated NEDD8-dissociated protein 1

1

6

High-throughput

0.536

High

407325

CSN5
COP9 signalosome complex subunit 5

1

16

High-throughput

0.536

High

407326

CUL5
Cullin-5

1

20

High-throughput

0.536

High

370896

MYC
Myc proto-oncogene protein

2

12

High-throughput

0.533

High

407277

GOGA2
Golgin subfamily A member 2

1

7

High-throughput

0.523

High

407281

SNF5
SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily B member 1

1

2

High-throughput

0.494

High

407292

FL2D
Pre-mRNA-splicing regulator WTAP

1

6

High-throughput

0.489

High

407343

MET14
N(6)-adenosine-methyltransferase non-catalytic subunit METTL14

1

14

High-throughput

0.489

High

407273

2ABB
Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B beta isoform

1

6

High-throughput

0.484

High

131280

EIF3F
Eukaryotic translation initiation factor 3 subunit F

1

11

Small-scale

0.479

High

141272

DDX3X
ATP-dependent RNA helicase DDX3X

1

6

Small-scale

0.479

High

187244

SHIP2
Phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 2

1

8

High-throughput

0.479

High

209431

SERA
D-3-phosphoglycerate dehydrogenase

1

6

Small-scale

0.479

High

240460

PRKN
E3 ubiquitin-protein ligase parkin

1

18

High-throughput

0.479

High

271809

OBSL1
Obscurin-like protein 1

1

8

High-throughput

0.479

High

302308

RNF8
E3 ubiquitin-protein ligase RNF8

1

15

High-throughput

0.479

High

319282

UFL1
E3 UFM1-protein ligase 1

1

2

High-throughput

0.479

High

323082

TRI37
E3 ubiquitin-protein ligase TRIM37

1

20

High-throughput

0.479

High

407235

P53
Cellular tumor antigen p53

1

8

Small-scale

0.479

High

407243

ROA1
Heterogeneous nuclear ribonucleoprotein A1

1

7

High-throughput

0.479

High

407244

CFTR
Cystic fibrosis transmembrane conductance regulator

1

17

High-throughput

0.479

High

407253

CBL
E3 ubiquitin-protein ligase CBL

1

12

High-throughput

0.479

High

407257

IF4A3
Eukaryotic initiation factor 4A-III

1

11

High-throughput

0.479

High

407259

CRK
Adapter molecule crk

1

20

High-throughput

0.479

High

407260

YAP1
Transcriptional coactivator YAP1

1

17

High-throughput

0.479

High

407262

UBE2A
Ubiquitin-conjugating enzyme E2 A

1

1

High-throughput

0.479

High

407263

MCM2
DNA replication licensing factor MCM2

1

3

High-throughput

0.479

High

407269

UBE2H
Ubiquitin-conjugating enzyme E2 H

1

9

High-throughput

0.479

High

407271

PPIA
Peptidyl-prolyl cis-trans isomerase A

1

5

High-throughput

0.479

High

407272

1433Z
14-3-3 protein zeta/delta

1

20

Small-scale

0.479

High

407280

TFCP2
Alpha-globin transcription factor CP2

1

4

High-throughput

0.479

High

407283

TRI26
Tripartite motif-containing protein 26

1

13

Small-scale

0.479

High

407288

DCTN1
Dynactin subunit 1

1

16

High-throughput

0.479

High

407293

U5S1
116 kDa U5 small nuclear ribonucleoprotein component

1

6

High-throughput

0.479

High

407294

IQCB1
IQ calmodulin-binding motif-containing protein 1

1

14

High-throughput

0.479

High

407297

MK06
Mitogen-activated protein kinase 6

1

3

High-throughput

0.479

High

407299

LARP7
La-related protein 7

1

11

High-throughput

0.479

High

407302

OTU1
Ubiquitin thioesterase OTU1

1

7

High-throughput

0.479

High

407303

FBW10
F-box/WD repeat-containing protein 10

1

7

High-throughput

0.479

High

407304

VIR
Protein virilizer homolog

1

5

High-throughput

0.479

High

407308

FGD5
FYVE, RhoGEF and PH domain-containing protein 5

1

7

High-throughput

0.479

High

407319

UBP38
Ubiquitin carboxyl-terminal hydrolase 38

1

9

Small-scale

0.479

High

407321

PAPD5
Terminal nucleotidyltransferase 4B

1

3

High-throughput

0.479

High

407327

ZUP1
Zinc finger-containing ubiquitin peptidase 1

1

7

Small-scale

0.479

High

407328

AP2M1
AP-2 complex subunit mu

1

8

High-throughput

0.479

High

407329

SNR40
U5 small nuclear ribonucleoprotein 40 kDa protein

1

8

High-throughput

0.479

High

407334

NECD
Necdin

1

5

High-throughput

0.479

High

407336

FACD2
Fanconi anemia group D2 protein

1

8

High-throughput

0.479

High

407337

ACE2
Angiotensin-converting enzyme 2

1

6

High-throughput

0.479

High

407338

HOIL1
RanBP-type and C3HC4-type zinc finger-containing protein 1

1

9

High-throughput

0.479

High

407341

RN208
RING finger protein 208

1

20

Small-scale

0.479

High

407342

GAN
Gigaxonin

1

5

High-throughput

0.479

High

407344

CYLD
Ubiquitin carboxyl-terminal hydrolase CYLD

1

10

High-throughput

0.479

High

407345

ANLN
Anillin

1

11

High-throughput

0.479

High

407349

HDAC6
Protein deacetylase HDAC6

1

13

High-throughput

0.479

High

407350

ZRAN1
Ubiquitin thioesterase ZRANB1

1

12

High-throughput

0.479

High

407355

UCHL5
Ubiquitin carboxyl-terminal hydrolase isozyme L5

1

9

Small-scale

0.479

High

246385

KDM1A
Lysine-specific histone demethylase 1A

1

3

High-throughput

0.464

High

407267

RS20
Small ribosomal subunit protein uS10

1

0

High-throughput

0.458

High

407270

RBX1
E3 ubiquitin-protein ligase RBX1

1

0

High-throughput

0.458

High

407284

NFX1
Transcriptional repressor NF-X1

1

0

High-throughput

0.458

High

407332

CI072
Guanine nucleotide exchange factor C9orf72

1

0

High-throughput

0.458

High

407354

CIA30
Complex I intermediate-associated protein 30, mitochondrial

1

0

Small-scale

0.458

High

284527

ECI2
Enoyl-CoA delta isomerase 2

1

2

High-throughput

0.445

High

342719

HERC2
E3 ubiquitin-protein ligase HERC2

1

3

High-throughput

0.445

High

407266

GBRL2
Gamma-aminobutyric acid receptor-associated protein-like 2

1

20

High-throughput

0.445

High

407278

LG3BP
Galectin-3-binding protein

1

8

High-throughput

0.445

High

407301

LRRK2
Leucine-rich repeat serine/threonine-protein kinase 2

1

8

High-throughput

0.445

High

407317

KIBRA
Protein KIBRA

1

17

High-throughput

0.445

High

407340

GBRL1
Gamma-aminobutyric acid receptor-associated protein-like 1

1

20

High-throughput

0.445

High

239658

PCDH7
Protocadherin-7

1

3

High-throughput

0.437

High

293035

CD123
Translation initiation factor eIF2 assembly protein

1

8

High-throughput

0.437

High

324393

HEXI1
Protein HEXIM1

1

18

High-throughput

0.437

High

407238

IGF1R
Insulin-like growth factor 1 receptor

1

3

High-throughput

0.437

High

407248

TIMP2
Metalloproteinase inhibitor 2

1

6

High-throughput

0.437

High

407250

CEBPB
CCAAT/enhancer-binding protein beta

1

5

High-throughput

0.437

High

407252

EFNA1
Ephrin-A1

1

20

High-throughput

0.437

High

407261

NR2C2
Nuclear receptor subfamily 2 group C member 2

1

2

High-throughput

0.437

High

407264

EFNA3
Ephrin-A3

1

20

High-throughput

0.437

High

407265

EFNA4
Ephrin-A4

1

20

High-throughput

0.437

High

407268

WDR5
WD repeat-containing protein 5

1

5

High-throughput

0.437

High

407274

EWS
RNA-binding protein EWS

1

2

High-throughput

0.437

High

407282

CHD3
Chromodomain-helicase-DNA-binding protein 3

1

20

High-throughput

0.437

High

407287

DX39B
Spliceosome RNA helicase DDX39B

1

20

High-throughput

0.437

High

407291

CHD4
Chromodomain-helicase-DNA-binding protein 4

1

20

High-throughput

0.437

High

407296

EZH2
Histone-lysine N-methyltransferase EZH2

1

9

High-throughput

0.437

High

407307

PRP8
Pre-mRNA-processing-splicing factor 8

1

8

High-throughput

0.437

High

407309

TRI67
Tripartite motif-containing protein 67

1

20

High-throughput

0.437

High

407310

MEPCE
7SK snRNA methylphosphate capping enzyme

1

11

High-throughput

0.437

High

407322

UBS3B
Ubiquitin-associated and SH3 domain-containing protein B

1

20

High-throughput

0.437

High

407324

HDAC2
Histone deacetylase 2

1

12

High-throughput

0.437

High

407330

DDRGK
DDRGK domain-containing protein 1

1

2

High-throughput

0.437

High

407352

PHTF1
Protein PHTF1

1

9

High-throughput

0.437

High

407353

AAR2
Protein AAR2 homolog

1

6

High-throughput

0.437

High

407279

NCBP1
Nuclear cap-binding protein subunit 1

1

0

High-throughput

0.426

High

877

SIM26
Small integral membrane protein 26

1

6

High-throughput

0.407

High

109142

G4U4J3
Terminal nucleotidyltransferase 4B

1

3

High-throughput

0.407

High

155377

AQP7
Aquaporin-7

1

1

Small-scale

0.407

High

407254

HEMH
Ferrochelatase, mitochondrial

1

2

High-throughput

0.407

High

407300

NCBP3
Nuclear cap-binding protein subunit 3

1

1

High-throughput

0.407

High

407316

SULF2
Extracellular sulfatase Sulf-2

1

9

High-throughput

0.407

High

407320

MOT11
Monocarboxylate transporter 11

1

3

High-throughput

0.407

High

407331

NEUL4
Neuralized-like protein 4

1

2

High-throughput

0.407

High

407318

TEX11
Testis-expressed protein 11

2

0

High-throughput

0.316

High

407347

B3GN2
N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase 2

1

0

High-throughput

0.249

Low


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Last updated: 11Aug2025