HitPredict

Interactor 1: NTRK1 (P04629)
High affinity nerve growth factor receptor (EC 2.7.10.1) (Neurotrophic tyrosine kinase receptor type 1) (TRK1-transforming tyrosine kinase protein) (Tropomyosin-related kinase A) (Tyrosine kinase receptor) (Tyrosine kinase receptor A) (Trk-A) (gp140trk) (p140-TrkA)
Gene: NTRK1

Interactor 2: OSBL8 (Q9BZF1)
Oxysterol-binding protein-related protein 8 (ORP-8) (OSBP-related protein 8)
Gene: OSBPL8

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	0.80	0.553

Property	Details
Experiments	25921289
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	PH~PK_Tyr_Ser-Thr
Common GO terms	-
Homologous interactions	17

Homologous interactions

Color coding for hit scores

	1 796 Hs			1 889
+	Hs
		508182 FGFR1_HUMAN (195-794): 0: 545: 26.34		OSBL8_HUMAN (1-889): 0: 1210: 100.00
+	Hs
		1081595 NTRK3_HUMAN (36-796): 1.63e-174: 525: 49.37		OSBL8_HUMAN (1-889): 0: 1210: 100.00
+	Hs
		434280 RET_HUMAN (391-794): 3.5e-114: 374: 30.44		OSBL8_HUMAN (1-889): 0: 1210: 100.00
+	Hs
		435752 IGF1R_HUMAN (493-777): 6.97e-71: 255: 42.61		OSBL8_HUMAN (1-889): 0: 1210: 100.00
+	Hs
		1088140 DDR2_HUMAN (499-781): 3.37e-72: 254: 44.55		OSBL8_HUMAN (1-889): 0: 1210: 100.00
+	Hs
		411491 INSR_HUMAN (493-777): 3e-68: 248: 42.62		OSBL8_HUMAN (1-889): 0: 1210: 100.00
+	Hs
		537771 INSRR_HUMAN (493-782): 6.64e-66: 241: 42.91		OSBL8_HUMAN (1-889): 0: 1210: 100.00
+	Hs
		1318012 ALK_HUMAN (505-790): 8.72e-63: 231: 42.07		OSBL8_HUMAN (1-889): 0: 1210: 100.00
+	Hs
		537772 INSRR_HUMAN (493-782): 6.64e-66: 241: 42.91		OSBL5_HUMAN (32-889): 0: 1012: 54.21
+	Hs
		385387 NTRK1_HUMAN (1-796): 0: 621: 100.00		OSBL9_HUMAN (209-743): 5.35e-159: 484: 30.32
+	Hs
		384259 NTRK1_HUMAN (1-796): 0: 621: 100.00		OSBP1_HUMAN (236-758): 1.11e-141: 441: 20.42
+	Hs
		385465 NTRK1_HUMAN (1-796): 0: 621: 100.00		OSB11_HUMAN (345-749): 6.21e-130: 409: 29.62
+	Hs
		508159 FGFR1_HUMAN (195-794): 0: 545: 26.34		OSBL9_HUMAN (209-743): 5.35e-159: 484: 30.32
+	Hs
		603057 NTRK3_HUMAN (36-796): 1.63e-174: 525: 49.37		OSBP1_HUMAN (236-758): 1.11e-141: 441: 20.42
+	Hs
		508177 FGFR1_HUMAN (195-794): 0: 545: 26.34		OSB11_HUMAN (345-749): 6.21e-130: 409: 29.62
+	Hs
		435736 IGF1R_HUMAN (493-777): 6.97e-71: 255: 42.61		OSBL9_HUMAN (209-743): 5.35e-159: 484: 30.32
+	Hs
		435750 IGF1R_HUMAN (493-777): 6.97e-71: 255: 42.61		OSB11_HUMAN (345-749): 6.21e-130: 409: 29.62