Protein: CXB5
Gap junction beta-5 protein (Connexin-31.1) (Cx31.1)

Gene: CXB5, GJB5
Organism: Homo sapiens
Interactions: 71
UniProt ID: O95377

Gene Ontology (top 5):
GO:0005243 - gap junction channel activity
GO:0005922 - connexin complex
GO:0007267 - cell-cell signaling
GO:0008544 - epidermis development
GO:0060707 - trophoblast giant cell differentiation

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

74148

SMIM1
Small integral membrane protein 1

2

1

High-throughput

0.553

High

208938

CYB5B
Cytochrome b5 type B

2

1

High-throughput

0.553

High

280078

SC22B
Vesicle-trafficking protein SEC22b

2

9

High-throughput

0.553

High

331458

APOL3
Apolipoprotein L3

2

5

High-throughput

0.553

High

335227

COMT
Catechol O-methyltransferase

2

3

High-throughput

0.553

High

335228

IBP5
Insulin-like growth factor-binding protein 5

2

3

High-throughput

0.553

High

335230

AQP1
Aquaporin-1

2

4

High-throughput

0.553

High

335231

MIP
Lens fiber major intrinsic protein

2

4

High-throughput

0.553

High

335234

T4S4
Transmembrane 4 L6 family member 4

2

2

High-throughput

0.553

High

335237

LIPR1
Inactive pancreatic lipase-related protein 1

2

1

High-throughput

0.553

High

335243

CTXN3
Cortexin-3

2

2

High-throughput

0.553

High

335244

SGMR2
Sigma intracellular receptor 2

2

2

High-throughput

0.553

High

335245

TM128
Transmembrane protein 128

2

2

High-throughput

0.553

High

335246

M4A13
Membrane-spanning 4-domains subfamily A member 13

2

6

High-throughput

0.553

High

335247

RTP2
Receptor-transporting protein 2

2

1

High-throughput

0.553

High

335249

PLPP4
Phospholipid phosphatase 4

2

1

High-throughput

0.553

High

335250

VSTM1
V-set and transmembrane domain-containing protein 1

2

1

High-throughput

0.553

High

335251

LRP10
Low-density lipoprotein receptor-related protein 10

2

2

High-throughput

0.553

High

335252

S41A1
Solute carrier family 41 member 1

2

3

High-throughput

0.553

High

335254

TM86A
Lysoplasmalogenase TMEM86A

2

5

High-throughput

0.553

High

335257

SRALN
Sarcoplasmic/endoplasmic reticulum calcium ATPase regulator ARLN

2

2

High-throughput

0.553

High

335258

FAM3C
Protein FAM3C

2

3

High-throughput

0.553

High

335259

SC22A
Vesicle-trafficking protein SEC22a

2

9

High-throughput

0.553

High

335260

S41A2
Solute carrier family 41 member 2

2

3

High-throughput

0.553

High

335261

APOL2
Apolipoprotein L2

2

5

High-throughput

0.553

High

335262

ZNT2
Proton-coupled zinc antiporter SLC30A2

2

14

High-throughput

0.553

High

335266

TMM60
Transmembrane protein 60

2

2

High-throughput

0.553

High

335268

RPRM
Protein reprimo

2

2

High-throughput

0.553

High

335269

S38A7
Sodium-coupled neutral amino acid transporter 7

2

7

High-throughput

0.553

High

335270

LPAR3
Lysophosphatidic acid receptor 3

2

10

High-throughput

0.553

High

335272

PGAP2
Acyltransferase PGAP2

2

2

High-throughput

0.553

High

335274

SERP1
Stress-associated endoplasmic reticulum protein 1

2

1

High-throughput

0.553

High

335226

MLRV
Myosin regulatory light chain 2, ventricular/cardiac muscle isoform

1

1

High-throughput

0.494

High

335233

PCGF2
Polycomb group RING finger protein 2

1

1

High-throughput

0.494

High

335241

MED1
Mediator of RNA polymerase II transcription subunit 1

1

1

High-throughput

0.494

High

335263

TRIM2
Tripartite motif-containing protein 2

1

6

High-throughput

0.494

High

85933

IGLL5
Immunoglobulin lambda-like polypeptide 5

1

5

High-throughput

0.489

High

335212

A1AT
Alpha-1-antitrypsin

1

1

High-throughput

0.489

High

335213

AACT
Alpha-1-antichymotrypsin

1

1

High-throughput

0.489

High

335222

ALBU
Albumin

1

2

High-throughput

0.489

High

335223

TRFE
Serotransferrin

1

3

High-throughput

0.489

High

335224

TRFL
Lactotransferrin

1

3

High-throughput

0.489

High

335229

ZA2G
Zinc-alpha-2-glycoprotein

1

3

High-throughput

0.489

High

335232

LCN1
Lipocalin-1

1

1

High-throughput

0.489

High

335239

NGAL
Neutrophil gelatinase-associated lipocalin

1

2

High-throughput

0.489

High

335271

DMBT1
Scavenger receptor cysteine-rich domain-containing protein DMBT1

1

1

High-throughput

0.489

High

335221

LMNA
Prelamin-A/C [Cleaved into: Lamin-A/C

1

9

High-throughput

0.439

High

335267

C1GLT
Glycoprotein-N-acetylgalactosamine 3-beta-galactosyltransferase 1

1

2

High-throughput

0.439

High

335240

CLH1
Clathrin heavy chain 1

1

2

Small-scale

0.437

High

335217

IGHG3
Immunoglobulin heavy constant gamma 3

1

6

High-throughput

0.407

High

335218

IGHM
Immunoglobulin heavy constant mu

1

7

High-throughput

0.407

High

335219

IGHA1
Immunoglobulin heavy constant alpha 1

1

7

High-throughput

0.407

High

335220

IGHA2
Immunoglobulin heavy constant alpha 2

1

8

High-throughput

0.407

High

335248

TSPO2
Translocator protein 2

2

0

High-throughput

0.316

High

335253

PLPP6
Polyisoprenoid diphosphate/phosphate phosphohydrolase PLPP6

2

0

High-throughput

0.316

High

335255

JAGN1
Protein jagunal homolog 1

2

0

High-throughput

0.316

High

335265

SNAB
Beta-soluble NSF attachment protein

2

0

High-throughput

0.316

High

335273

ERG28
Ergosterol biosynthetic protein 28 homolog

2

0

High-throughput

0.316

High

286513

SG2A1
Mammaglobin-B

1

0

High-throughput

0.279

Low

335210

SG1D1
Secretoglobin family 1D member 1

1

0

High-throughput

0.279

Low

335211

CERU
Ceruloplasmin

1

0

High-throughput

0.279

Low

335214

CYTS
Cystatin-S

1

0

High-throughput

0.279

Low

335215

IGJ
Immunoglobulin J chain

1

0

High-throughput

0.279

Low

335216

PIGR
Polymeric immunoglobulin receptor

1

0

High-throughput

0.279

Low

335225

CLUS
Clusterin

1

0

High-throughput

0.279

Low

335235

TIG1
Retinoic acid receptor responder protein 1

1

0

High-throughput

0.279

Low

335238

LYSC
Lysozyme C

1

0

High-throughput

0.279

Low

335242

PROL4
Proline-rich protein 4

1

0

High-throughput

0.279

Low

335256

BPIB1
BPI fold-containing family B member 1

1

0

High-throughput

0.279

Low

335264

LACRT
Extracellular glycoprotein lacritin

1

0

High-throughput

0.279

Low

335236

GSK3B
Glycogen synthase kinase-3 beta

1

0

High-throughput

0.265

Low


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Last updated: 11Aug2025