HitPredict - High confidence protein-protein interactions

Interactor 1: P53 (P04637)
Cellular tumor antigen p53 (Antigen NY-CO-13) (Phosphoprotein p53) (Tumor suppressor p53)
Gene: TP53

Interactor 2: JUN (P05412)
Transcription factor Jun (Activator protein 1) (AP1) (Proto-oncogene c-Jun) (Transcription factor AP-1 subunit Jun) (V-jun avian sarcoma virus 17 oncogene homolog) (p39)
Gene: JUN

Species: Homo sapiens

Source: mint

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.55	0.60	0.576

Property	Details
Experiments	31182485, 25609649
Identification Methods	two hybrid, anti bait coimmunoprecipitation
Interaction Type	direct interaction, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0000122 - negative regulation of transcription by RNA polymerase II GO:0000785 - chromatin GO:0000976 - transcription cis-regulatory region binding GO:0000978 - RNA polymerase II cis-regulatory region sequence-specific DNA binding GO:0000981 - DNA-binding transcription factor activity, RNA polymerase II-specific and 19 others more... GO:0001227 - DNA-binding transcription repressor activity, RNA polymerase II-specific GO:0001228 - DNA-binding transcription activator activity, RNA polymerase II-specific GO:0003677 - DNA binding GO:0003700 - DNA-binding transcription factor activity GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0005667 - transcription regulator complex GO:0006357 - regulation of transcription by RNA polymerase II GO:0007179 - transforming growth factor beta receptor signaling pathway GO:0019899 - enzyme binding GO:0031625 - ubiquitin protein ligase binding GO:0043065 - positive regulation of apoptotic process GO:0045892 - negative regulation of DNA-templated transcription GO:0045893 - positive regulation of DNA-templated transcription GO:0045944 - positive regulation of transcription by RNA polymerase II GO:0051726 - regulation of cell cycle GO:0061629 - RNA polymerase II-specific DNA-binding transcription factor binding GO:0140296 - general transcription initiation factor binding GO:1902895 - positive regulation of miRNA transcription
Homologous interactions	4

Homologous interactions

Color coding for hit scores

	1	393
Hs

1	331

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Last updated: 15 Jul 2024