Protein: KBTB6
Kelch repeat and BTB domain-containing protein 6

Gene: KBTB6, KBTBD6
Organism: Homo sapiens
Interactions: 108
UniProt ID: Q86V97

Gene Ontology (top 5):
GO:0005634 - nucleus
GO:0005737 - cytoplasm
GO:0005829 - cytosol
GO:0006986 - response to unfolded protein
GO:0009968 - negative regulation of signal transduction

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

1113573

CUL3
Cullin-3

10

20

Small-scale

0.975

High

1290277

KBTB7
Kelch repeat and BTB domain-containing protein 7

7

19

Small-scale

0.969

High

1290299

GBRL1
Gamma-aminobutyric acid receptor-associated protein-like 1

2

20

Small-scale

0.866

High

328058

GBRAP
Gamma-aminobutyric acid receptor-associated protein

2

20

Small-scale

0.859

High

1290297

MLP3B
Microtubule-associated protein 1 light chain 3 beta

2

20

Small-scale

0.857

High

952228

GBRL2
Gamma-aminobutyric acid receptor-associated protein-like 2

2

20

Small-scale

0.846

High

1290293

MLP3C
Microtubule-associated protein 1 light chain 3 gamma

2

20

Small-scale

0.817

High

1111416

DGKZ
Diacylglycerol kinase zeta

1

2

High-throughput

0.691

High

1154865

NEDD8
Ubiquitin-like protein NEDD8

1

3

High-throughput

0.691

High

1290314

FXL17
F-box/LRR-repeat protein 17

1

17

High-throughput

0.691

High

643511

PIMT
Protein-L-isoaspartate(D-aspartate) O-methyltransferase

3

4

High-throughput

0.667

High

1290276

DOK4
Docking protein 4

3

5

High-throughput

0.667

High

1290317

ARI1
E3 ubiquitin-protein ligase ARIH1

3

14

High-throughput

0.667

High

1290302

MLP3A
Microtubule-associated protein 1 light chain 3 alpha

1

20

Small-scale

0.647

High

326205

ALX3
Homeobox protein aristaless-like 3

2

3

High-throughput

0.628

High

681856

RBTN2
Rhombotin-2

2

8

High-throughput

0.628

High

868365

CDX1
Homeobox protein CDX-1

2

7

High-throughput

0.628

High

957433

UBC12
NEDD8-conjugating enzyme Ubc12

2

16

High-throughput

0.628

High

983868

RBX1
E3 ubiquitin-protein ligase RBX1

2

9

Small-scale

0.628

High

1241003

L2GL2
LLGL scribble cell polarity complex component 2

2

3

High-throughput

0.628

High

1252618

ZN574
Zinc finger protein 574

2

1

High-throughput

0.628

High

1290271

AROS
Active regulator of SIRT1

2

1

High-throughput

0.628

High

1290301

TXNIP
Thioredoxin-interacting protein

2

7

High-throughput

0.628

High

1290283

KLH29
Kelch-like protein 29

1

20

High-throughput

0.618

High

288185

CLC3A
C-type lectin domain family 3 member A

3

1

High-throughput

0.604

High

1290305

EAF6
Chromatin modification-related protein MEAF6

2

0

High-throughput

0.602

High

258966

DNJA2
DnaJ homolog subfamily A member 2

2

4

High-throughput

0.601

High

503618

TFPT
TCF3 fusion partner

2

1

High-throughput

0.601

High

1239861

CAVN1
Caveolae-associated protein 1

2

1

High-throughput

0.601

High

1290272

NUDC3
NudC domain-containing protein 3

2

20

Small-scale

0.601

High

1290278

CSN5
COP9 signalosome complex subunit 5

2

13

Small-scale

0.601

High

1290288

OSBL9
Oxysterol-binding protein-related protein 9

2

6

Small-scale

0.601

High

385917

LMNA
Prelamin-A/C [Cleaved into: Lamin-A/C

2

4

High-throughput

0.584

High

980890

H2B1C
Histone H2B type 1-C/E/F/G/I

2

1

High-throughput

0.584

High

1251825

PPR21
Protein phosphatase 1 regulatory subunit 21

2

2

High-throughput

0.574

High

1290273

RBFA
Putative ribosome-binding factor A, mitochondrial

2

1

High-throughput

0.574

High

628630

CAP7
Azurocidin

2

6

High-throughput

0.558

High

1290275

IN80E
INO80 complex subunit E

2

2

High-throughput

0.549

High

167519

TX1B3
Tax1-binding protein 3

1

5

High-throughput

0.536

High

216738

HTRA2
Serine protease HTRA2, mitochondrial

1

1

High-throughput

0.536

High

469809

CATG
Cathepsin G

1

3

High-throughput

0.536

High

605010

HXB6
Homeobox protein Hox-B6

1

6

High-throughput

0.536

High

961187

FGF12
Fibroblast growth factor 12

1

4

High-throughput

0.536

High

1273891

BHA15
Class A basic helix-loop-helix protein 15

1

3

High-throughput

0.536

High

1290280

ZN524
Zinc finger protein 524

1

4

High-throughput

0.536

High

1290281

ZN653
Zinc finger protein 653

1

3

High-throughput

0.536

High

1290286

DCNL1
DCN1-like protein 1

1

11

High-throughput

0.536

High

1290287

ZN414
Zinc finger protein 414

1

5

High-throughput

0.536

High

1290290

PLCD4
1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-4

1

2

High-throughput

0.536

High

1290295

MK67I
MKI67 FHA domain-interacting nucleolar phosphoprotein

1

3

High-throughput

0.536

High

1290306

MAGE1
Melanoma-associated antigen E1

1

1

High-throughput

0.536

High

1290307

E41L5
Band 4.1-like protein 5

1

3

High-throughput

0.536

High

1290309

ABC3C
DNA dC->dU-editing enzyme APOBEC-3C

1

1

High-throughput

0.536

High

1290313

IKBL1
NF-kappa-B inhibitor-like protein 1

1

1

High-throughput

0.536

High

1290316

ABT1
Activator of basal transcription 1

1

1

High-throughput

0.536

High

1092458

TIAM1
Rho guanine nucleotide exchange factor TIAM1

1

7

Small-scale

0.515

High

788701

SRP14
Signal recognition particle 14 kDa protein

1

0

High-throughput

0.513

High

824217

RL13A
Large ribosomal subunit protein uL13

1

0

High-throughput

0.513

High

984840

RL31
Large ribosomal subunit protein eL31

1

0

High-throughput

0.513

High

985749

RL11
Large ribosomal subunit protein uL5

1

0

High-throughput

0.513

High

572451

DRD2
D(2) dopamine receptor

1

2

Small-scale

0.512

High

571197

HGF
Hepatocyte growth factor

1

4

High-throughput

0.489

High

652651

GNLY
Granulysin

1

3

High-throughput

0.489

High

1011304

RT25
Small ribosomal subunit protein mS25

1

1

High-throughput

0.489

High

1099628

NOGG
Noggin

1

3

High-throughput

0.489

High

1149665

SURF2
Surfeit locus protein 2

1

1

High-throughput

0.489

High

1290282

RUSD4
Pseudouridylate synthase RPUSD4, mitochondrial

1

1

High-throughput

0.489

High

1290285

RT24
Small ribosomal subunit protein uS3m

1

1

High-throughput

0.489

High

1290300

RM18
Large ribosomal subunit protein uL18m

1

1

High-throughput

0.489

High

1290304

GREM2
Gremlin-2

1

1

High-throughput

0.489

High

1290315

IL17B
Interleukin-17B

1

3

High-throughput

0.489

High

221943

FOXS1
Forkhead box protein S1

1

3

High-throughput

0.479

High

279409

TULP3
Tubby-related protein 3

1

1

High-throughput

0.479

High

315743

RECQ4
ATP-dependent DNA helicase Q4

1

1

High-throughput

0.479

High

584114

FOSL2
Fos-related antigen 2

1

7

High-throughput

0.479

High

634508

LMNB1
Lamin-B1

1

4

High-throughput

0.479

High

693826

RL10
Large ribosomal subunit protein uL16

1

1

High-throughput

0.479

High

837700

LAP2B
Lamina-associated polypeptide 2, isoforms beta/gamma

1

1

High-throughput

0.479

High

1087844

NFIA
Nuclear factor 1 A-type

1

2

High-throughput

0.479

High

1133507

NFIX
Nuclear factor 1 X-type

1

2

High-throughput

0.479

High

1161816

ZSC26
Zinc finger and SCAN domain-containing protein 26

1

4

High-throughput

0.479

High

1178227

CL16A
Protein CLEC16A

1

1

High-throughput

0.479

High

1250407

ZN562
Zinc finger protein 562

1

3

High-throughput

0.479

High

1290274

ZFP41
Zinc finger protein 41 homolog

1

6

High-throughput

0.479

High

1290279

RL36L
Ribosomal protein eL42-like

1

1

High-throughput

0.479

High

1290284

AP2M1
AP-2 complex subunit mu

1

1

High-throughput

0.479

High

1290292

KLF16
Krueppel-like factor 16

1

6

High-throughput

0.479

High

1290296

PAR6B
Partitioning defective 6 homolog beta

1

4

High-throughput

0.479

High

1290303

DEFI6
Differentially expressed in FDCP 6 homolog

1

10

High-throughput

0.479

High

1290311

TE2IP
Telomeric repeat-binding factor 2-interacting protein 1

1

1

High-throughput

0.479

High

984454

RL30
Large ribosomal subunit protein eL30

1

0

High-throughput

0.458

High

1244169

TM10B
tRNA methyltransferase 10 homolog B

1

0

High-throughput

0.458

High

1290312

TLS1
Splicing factor C9orf78

1

0

High-throughput

0.458

High

725148

HXC9
Homeobox protein Hox-C9

1

10

High-throughput

0.445

High

1204709

TAF7L
Transcription initiation factor TFIID subunit 7-like

1

2

High-throughput

0.445

High

1290291

OSB11
Oxysterol-binding protein-related protein 11

1

6

Small-scale

0.445

High

1256501

CE128
Centrosomal protein of 128 kDa

1

7

High-throughput

0.437

High

1290308

LUC7L
Putative RNA-binding protein Luc7-like 1

1

1

High-throughput

0.437

High

596204

H12
Histone H1.2

1

0

Small-scale

0.426

High

168864

PLD2
Phospholipase D2

1

1

Small-scale

0.407

High

478291

HXD4
Homeobox protein Hox-D4

1

3

High-throughput

0.407

High

516106

CT456
Cancer/testis antigen family 45 member A6

1

1

High-throughput

0.407

High

1206666

LRC73
Leucine-rich repeat-containing protein 73

1

3

High-throughput

0.407

High

1290294

S4A5
Electrogenic sodium bicarbonate cotransporter 4

1

2

High-throughput

0.407

High

1290298

NUAK2
NUAK family SNF1-like kinase 2

1

2

High-throughput

0.407

High

1290310

STAU2
Double-stranded RNA-binding protein Staufen homolog 2

1

5

Small-scale

0.407

High

1290289

IMP2L
Mitochondrial inner membrane protease subunit 2

1

0

High-throughput

0.279

Low

1194786

GRPL2
GLIPR1-like protein 2

1

0

High-throughput

0.232

Low


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Last updated: 11Aug2025