HitPredict

Interactor 1: P53 (P04637)
Cellular tumor antigen p53 (Antigen NY-CO-13) (Phosphoprotein p53) (Tumor suppressor p53)
Gene: TP53

Interactor 2: HS90B (P08238)
Heat shock protein HSP 90-beta (HSP 90) (Heat shock 84 kDa) (HSP 84) (HSP84) (Heat shock protein family C member 3)
Gene: HSP90AB1

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.76	0.60	0.676

The method score is based on:

Property	Details
Experiments	32807901, 36749630, 23443559, 22939624
Identification Methods	affinity chromatography technology, luminescence based mammalian interactome mapping
Interaction Type	physical association

The annotation score is based on:

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0005737 - cytoplasm GO:0005739 - mitochondrion GO:0005829 - cytosol and 7 others more... GO:0031625 - ubiquitin protein ligase binding GO:0032991 - protein-containing complex GO:0042826 - histone deacetylase binding GO:0043066 - negative regulation of apoptotic process GO:0050821 - protein stabilization GO:0051726 - regulation of cell cycle GO:0097718 - disordered domain specific binding
Homologous interactions	4

Homologous interactions

Color coding for hit scores

	1	393
Hs

1	724

Service provided by Combinatics, Japan

Last updated: 15 Jul 2024