Interactor 1: P53 (P04637)
Cellular tumor antigen p53 (Antigen NY-CO-13) (Phosphoprotein p53) (Tumor suppressor p53)
Gene: TP53
Interactor 2: HMGB1 (P09429)
High mobility group protein B1 (High mobility group protein 1) (HMG-1)
Gene: HMGB1
Species: Homo sapiens
Source: intact
Category: Small-scale
Confidence: High
| Method score | Annotation score | Interaction score |
|---|---|---|
| 0.84 | 1.00 | 0.920 |
The method score is based on:
| Property | Details |
|---|---|
| Experiments | 11106654, 11748221, 9472015, 23063560 |
| Identification Methods | affinity chromatography technology, pull down, nuclear magnetic resonance, experimental interaction detection, cross-linking study, molecular sieving, isothermal titration calorimetry, far western blotting |
| Interaction Type | physical association, direct interaction |
The annotation score is based on:
| Property | Details |
|---|---|
| Interacting Pfam domains | HMG_box_2~TAD2 |
| Common GO terms | GO:0000122 - negative regulation of transcription by RNA polymerase II GO:0000976 - transcription cis-regulatory region binding GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0005783 - endoplasmic reticulum and 6 others more... |
| Homologous interactions | 9 |
Homologous interactions
Color coding for hit scores 
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Service provided by Combinatics, Japan
Last updated: 15 Jul 2024
