Protein: DESM
Desmin

Gene: DESM, DES
Organism: Homo sapiens
Interactions: 153
UniProt ID: P17661

Gene Ontology (top 5):
GO:0005200 - structural constituent of cytoskeleton
GO:0005634 - nucleus
GO:0005635 - nuclear envelope
GO:0005829 - cytosol
GO:0005882 - intermediate filament

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

474463

VIME
Vimentin

7

20

High-throughput

0.967

High

570352

GFAP
Glial fibrillary acidic protein

6

19

High-throughput

0.948

High

451118

NFL
Neurofilament light polypeptide

6

20

High-throughput

0.946

High

606086

PERI
Peripherin

4

20

High-throughput

0.898

High

606159

SYNCI
Syncoilin

3

20

Small-scale

0.877

High

606073

DESM
Desmin

3

20

Small-scale

0.849

High

341735

K2C75
Keratin, type II cytoskeletal 75

3

20

High-throughput

0.843

High

606074

K1C15
Keratin, type I cytoskeletal 15

3

20

High-throughput

0.843

High

451329

NFM
Neurofilament medium polypeptide

2

20

High-throughput

0.811

High

176326

SYNEM
Synemin

2

20

Small-scale

0.799

High

300625

KRT37
Keratin, type I cuticular Ha7

2

20

High-throughput

0.783

High

566237

K1C13
Keratin, type I cytoskeletal 13

2

20

High-throughput

0.783

High

606080

K1C20
Keratin, type I cytoskeletal 20

2

20

High-throughput

0.783

High

606114

KT33B
Keratin, type I cuticular Ha3-II

2

20

High-throughput

0.783

High

437084

K2C8
Keratin, type II cytoskeletal 8

2

20

High-throughput

0.754

High

606091

NEST
Nestin

1

20

High-throughput

0.691

High

606120

AINX
Alpha-internexin

1

20

High-throughput

0.691

High

606134

K2C73
Keratin, type II cytoskeletal 73

1

20

High-throughput

0.691

High

606126

PPR18
Phostensin

4

17

High-throughput

0.637

High

385049

K1C14
Keratin, type I cytoskeletal 14

1

20

High-throughput

0.618

High

385235

K2C6A
Keratin, type II cytoskeletal 6A

1

20

High-throughput

0.618

High

407249

K2C6B
Keratin, type II cytoskeletal 6B

1

20

High-throughput

0.618

High

407383

K2C1
Keratin, type II cytoskeletal 1

1

20

High-throughput

0.618

High

436788

K1C18
Keratin, type I cytoskeletal 18

1

20

High-throughput

0.618

High

475513

K1C19
Keratin, type I cytoskeletal 19

1

20

High-throughput

0.618

High

475741

K2C7
Keratin, type II cytoskeletal 7

1

20

High-throughput

0.618

High

476263

K1C16
Keratin, type I cytoskeletal 16

1

20

High-throughput

0.618

High

551534

K2C3
Keratin, type II cytoskeletal 3

1

20

High-throughput

0.618

High

551604

NFH
Neurofilament heavy polypeptide

1

20

High-throughput

0.618

High

566095

K1C10
Keratin, type I cytoskeletal 10

1

20

High-throughput

0.618

High

566328

K2C5
Keratin, type II cytoskeletal 5

1

20

High-throughput

0.618

High

606081

K22E
Keratin, type II cytoskeletal 2 epidermal

1

20

High-throughput

0.618

High

606090

K2C6C
Keratin, type II cytoskeletal 6C

1

20

High-throughput

0.618

High

606102

K22O
Keratin, type II cytoskeletal 2 oral

1

20

High-throughput

0.618

High

606105

K1C17
Keratin, type I cytoskeletal 17

1

20

High-throughput

0.618

High

606115

K2C72
Keratin, type II cytoskeletal 72

1

20

High-throughput

0.618

High

606130

K2C1B
Keratin, type II cytoskeletal 1b

1

20

High-throughput

0.618

High

606152

K1C12
Keratin, type I cytoskeletal 12

1

20

High-throughput

0.618

High

606165

KRT84
Keratin, type II cuticular Hb4

1

20

High-throughput

0.618

High

606127

CDC73
Parafibromin

2

1

Small-scale

0.614

High

606106

ECHP
Peroxisomal bifunctional enzyme

2

2

High-throughput

0.611

High

248670

PEPL
Periplakin

2

20

High-throughput

0.606

High

297748

PIAS2
E3 SUMO-protein ligase PIAS2

2

7

High-throughput

0.606

High

462978

YES
Tyrosine-protein kinase Yes

2

8

High-throughput

0.606

High

606077

DDX6
Probable ATP-dependent RNA helicase DDX6

2

10

High-throughput

0.606

High

606095

LBX1
Transcription factor LBX1

2

2

High-throughput

0.606

High

606100

RNF4
E3 ubiquitin-protein ligase RNF4

2

5

High-throughput

0.606

High

606118

TCEA2
Transcription elongation factor A protein 2

2

3

High-throughput

0.606

High

606163

NEK6
Serine/threonine-protein kinase Nek6

2

15

High-throughput

0.606

High

606170

ZMYM5
Zinc finger MYM-type protein 5

2

1

High-throughput

0.606

High

606171

BAG5
BAG family molecular chaperone regulator 5

2

6

High-throughput

0.606

High

606108

MTM1
Myotubularin

1

3

Small-scale

0.604

High

606150

AURKB
Aurora kinase B

2

9

Small-scale

0.595

High

606166

TBA8
Tubulin alpha-8 chain

2

2

High-throughput

0.584

High

606097

RPB7
DNA-directed RNA polymerase II subunit RPB7

2

0

High-throughput

0.580

High

606141

SPT22
Spermatogenesis-associated protein 22

2

1

High-throughput

0.574

High

297332

DYSF
Dysferlin

1

3

High-throughput

0.568

High

606085

MLH1
DNA mismatch repair protein Mlh1

1

0

Small-scale

0.561

High

606169

DUX4
Double homeobox protein 4

1

6

High-throughput

0.561

High

65015

GG6L9
Golgin subfamily A member 6-like protein 9

2

20

High-throughput

0.553

High

606096

LMO4
LIM domain transcription factor LMO4

2

12

High-throughput

0.553

High

606122

C19L2
CWF19-like protein 2

2

2

High-throughput

0.553

High

606123

LONF3
LON peptidase N-terminal domain and RING finger protein 3

2

14

High-throughput

0.553

High

606142

CA216
UPF0500 protein C1orf216

2

3

High-throughput

0.553

High

606144

CT55
Cancer/testis antigen 55

2

3

High-throughput

0.553

High

606145

PIHD2
PIH1 domain-containing protein 2

2

4

High-throughput

0.553

High

606148

LENG1
Leukocyte receptor cluster member 1

2

3

High-throughput

0.553

High

606167

TFP11
Tuftelin-interacting protein 11

2

5

High-throughput

0.553

High

415332

HSPB1
Heat shock protein beta-1

1

9

High-throughput

0.541

High

445724

ENOA
Alpha-enolase

1

2

High-throughput

0.541

High

606138

CLIP4
CAP-Gly domain-containing linker protein 4

1

17

High-throughput

0.541

High

125982

RB27B
Ras-related protein Rab-27B

1

3

High-throughput

0.536

High

348962

LATS1
Serine/threonine-protein kinase LATS1

1

18

High-throughput

0.536

High

361104

SODC
Superoxide dismutase [Cu-Zn]

1

3

High-throughput

0.536

High

466626

GLI1
Zinc finger protein GLI1

1

11

High-throughput

0.536

High

470840

ODPA
Pyruvate dehydrogenase E1 component subunit alpha, somatic form, mitochondrial

1

8

High-throughput

0.536

High

563144

CFTR
Cystic fibrosis transmembrane conductance regulator

1

16

High-throughput

0.536

High

606082

ODO2
Dihydrolipoyllysine-residue succinyltransferase component of 2-oxoglutarate dehydrogenase complex, mitochondrial

1

5

High-throughput

0.536

High

606089

NSF
Vesicle-fusing ATPase

1

11

High-throughput

0.536

High

606104

MECOM
Histone-lysine N-methyltransferase MECOM

1

7

High-throughput

0.536

High

606124

KLH22
Kelch-like protein 22

1

3

High-throughput

0.536

High

606133

CARM1
Histone-arginine methyltransferase CARM1

1

9

High-throughput

0.536

High

606153

NUP88
Nuclear pore complex protein Nup88

1

1

High-throughput

0.536

High

606157

GAN
Gigaxonin

1

16

High-throughput

0.536

High

587552

DESP
Desmoplakin

1

20

Small-scale

0.527

High

606151

DUX5
Double homeobox protein 5

1

17

High-throughput

0.527

High

333294

SNAPN
SNARE-associated protein Snapin

1

0

High-throughput

0.518

High

606088

HD
Huntingtin

1

9

High-throughput

0.515

High

606093

RL34
Large ribosomal subunit protein eL34

1

0

High-throughput

0.513

High

606132

SPA24
Spermatogenesis-associated protein 24

1

0

High-throughput

0.513

High

606147

TRI63
E3 ubiquitin-protein ligase TRIM63

1

20

High-throughput

0.508

High

228405

DUX1
Double homeobox protein 1

1

20

High-throughput

0.506

High

384623

CRYAB
Alpha-crystallin B chain

1

9

Small-scale

0.501

High

606076

S10A1
Protein S100-A1

1

3

Small-scale

0.501

High

606137

PURA1
Adenylosuccinate synthetase isozyme 1

1

0

High-throughput

0.493

High

230499

KIF1C
Kinesin-like protein KIF1C

1

11

High-throughput

0.489

High

281877

MPPB
Mitochondrial-processing peptidase subunit beta

1

9

High-throughput

0.489

High

606107

MPPA
Mitochondrial-processing peptidase subunit alpha

1

9

High-throughput

0.489

High

606111

BMPR2
Bone morphogenetic protein receptor type-2

1

1

High-throughput

0.489

High

606121

RTN1
Reticulon-1

1

2

High-throughput

0.489

High

606131

TSN33
Tetraspanin-33

1

1

High-throughput

0.489

High

606135

RB6I2
ELKS/Rab6-interacting/CAST family member 1

1

18

High-throughput

0.489

High

606136

SYCE1
Synaptonemal complex central element protein 1

1

2

High-throughput

0.489

High

606139

ABTB2
Ankyrin repeat and BTB/POZ domain-containing protein 2

1

20

High-throughput

0.489

High

606140

RN214
RING finger protein 214

1

2

High-throughput

0.489

High

407788

SHBG
Sex hormone-binding globulin

1

2

Small-scale

0.481

High

457038

CAN1
Calpain-1 catalytic subunit

1

6

Small-scale

0.481

High

606075

NEBU
Nebulin

1

18

Small-scale

0.481

High

606083

BRCA1
Breast cancer type 1 susceptibility protein

1

11

High-throughput

0.481

High

606099

UBC9
SUMO-conjugating enzyme UBC9

1

4

High-throughput

0.481

High

606119

ITSN1
Intersectin-1

1

20

High-throughput

0.481

High

606154

TRI55
Tripartite motif-containing protein 55

1

20

High-throughput

0.481

High

606161

PKHA5
Pleckstrin homology domain-containing family A member 5

1

19

High-throughput

0.481

High

134547

SAP18
Histone deacetylase complex subunit SAP18

1

1

High-throughput

0.479

High

156932

CTRO
Citron Rho-interacting kinase

1

20

High-throughput

0.479

High

222700

PRC1
Protein regulator of cytokinesis 1

1

12

High-throughput

0.479

High

240688

PRKN
E3 ubiquitin-protein ligase parkin

1

17

High-throughput

0.479

High

330645

KI20A
Kinesin-like protein KIF20A

1

20

High-throughput

0.479

High

464793

SP1
Transcription factor Sp1

1

7

Small-scale

0.479

High

606078

1433T
14-3-3 protein theta

1

20

High-throughput

0.479

High

606094

UBP11
Ubiquitin carboxyl-terminal hydrolase 11

1

15

High-throughput

0.479

High

606103

KIF23
Kinesin-like protein KIF23

1

15

High-throughput

0.479

High

606109

CUL4A
Cullin-4A

1

20

High-throughput

0.479

High

606116

KIF14
Kinesin-like protein KIF14

1

20

High-throughput

0.479

High

606117

PCBP1
Poly(rC)-binding protein 1

1

4

Small-scale

0.479

High

606155

SPRTN
DNA-dependent metalloprotease SPRTN

1

3

High-throughput

0.479

High

606158

CHM4B
Charged multivesicular body protein 4b

1

5

High-throughput

0.479

High

606160

ECT2
Protein ECT2

1

20

High-throughput

0.479

High

606164

ANLN
Anillin

1

12

High-throughput

0.479

High

606168

HDAC6
Protein deacetylase HDAC6

1

12

High-throughput

0.479

High

606173

DTNA
Dystrobrevin alpha

1

5

Small-scale

0.479

High

606129

Q7KZS0
SUMO-conjugating enzyme UBC9

1

4

High-throughput

0.470

High

606146

JPH3
Junctophilin-3

1

1

High-throughput

0.470

High

606092

MAPK2
MAP kinase-activated protein kinase 2

1

0

Small-scale

0.460

High

606128

DUX4C
Double homeobox protein 4C

1

5

High-throughput

0.457

High

606162

SMUF2
E3 ubiquitin-protein ligase SMURF2

1

3

High-throughput

0.457

High

344086

PTBP3
Polypyrimidine tract-binding protein 3

1

2

High-throughput

0.445

High

429263

JUN
Transcription factor Jun

1

13

High-throughput

0.445

High

583439

ATF2
Cyclic AMP-dependent transcription factor ATF-2

1

11

High-throughput

0.445

High

606079

BMI1
Polycomb complex protein BMI-1

1

14

High-throughput

0.445

High

606087

STAT1
Signal transducer and activator of transcription 1-alpha/beta

1

4

Small-scale

0.445

High

606098

1433Z
14-3-3 protein zeta/delta

1

20

High-throughput

0.445

High

606110

SPTN1
Spectrin alpha chain, non-erythrocytic 1

1

12

Small-scale

0.445

High

606112

CAC1C
Voltage-dependent L-type calcium channel subunit alpha-1C

1

7

High-throughput

0.445

High

606172

ITM2B
Integral membrane protein 2B

1

9

High-throughput

0.445

High

606113

RBM39
RNA-binding protein 39

1

5

High-throughput

0.437

High

606143

M1AP
Meiosis 1 arrest protein

2

0

High-throughput

0.316

High

606101

RT05
Small ribosomal subunit protein uS5m

1

0

High-throughput

0.279

Low

606125

CCD92
Coiled-coil domain-containing protein 92

1

0

High-throughput

0.279

Low

606156

RSH6A
Radial spoke head protein 6 homolog A

1

0

High-throughput

0.279

Low

606149

S47A1
Multidrug and toxin extrusion protein 1

1

0

High-throughput

0.269

Low

606084

GDNF
Glial cell line-derived neurotrophic factor

1

0

High-throughput

0.249

Low


Service provided by Combinatics, Japan

Last updated: 11Aug2025