HitPredict

Interactor 1: P53 (P04637)
Cellular tumor antigen p53 (Antigen NY-CO-13) (Phosphoprotein p53) (Tumor suppressor p53)
Gene: TP53

Interactor 2: RO52 (P19474)
E3 ubiquitin-protein ligase TRIM21 (EC 2.3.2.27) (52 kDa Ro protein) (52 kDa ribonucleoprotein autoantigen Ro/SS-A) (RING finger protein 81) (Ro(SS-A)) (Sjoegren syndrome type A antigen) (SS-A) (Tripartite motif-containing protein 21)
Gene: TRIM21

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.55	0.60	0.578

Property	Details
Experiments	36749630
Identification Methods	affinity chromatography technology, pull down, enzymatic study
Interaction Type	physical association, direct interaction

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0003677 - DNA binding GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0005737 - cytoplasm GO:0005829 - cytosol and 1 others more... GO:0008270 - zinc ion binding
Homologous interactions	7

Homologous interactions

Color coding for hit scores

	1 393 Hs			1 475
+	Hs
		387560 P53_HUMAN (1-393): 0: 619: 100.00		TRI39_HUMAN (7-469): 3.45e-150: 440: 38.32
+	Hs
		386017 P53_HUMAN (1-393): 0: 619: 100.00		TRI27_HUMAN (1-466): 2.88e-141: 416: 37.17
+	Hs
		387032 P53_HUMAN (1-393): 0: 619: 100.00		TRI69_HUMAN (1-466): 3.44e-116: 352: 28.90
+	Hs
		386960 P53_HUMAN (1-393): 0: 619: 100.00		TRI72_HUMAN (1-465): 4.21e-106: 325: 26.09
+	Hs
		387106 P53_HUMAN (1-393): 0: 619: 100.00		TRIMM_HUMAN (87-468): 1.31e-62: 211: 35.60
+	Hs
		386629 P53_HUMAN (1-393): 0: 619: 100.00		TRI26_HUMAN (1-354): 6.86e-55: 193: 34.73
+	Hs
		387186 P53_HUMAN (1-393): 0: 619: 100.00		TRI41_HUMAN (1-44): 3.5e-10: 64.1: 45.83