Protein: ESS2
Splicing factor ESS-2 homolog (DiGeorge syndrome critical region 13) (DiGeorge syndrome critical region 14) (DiGeorge syndrome protein H) (DGS-H) (Protein ES2)

Gene: ESS2
Organism: Homo sapiens
Interactions: 156
UniProt ID: Q96DF8

Gene Ontology (top 5):
GO:0000398 - mRNA splicing, via spliceosome
GO:0005634 - nucleus
GO:0007399 - nervous system development
GO:0071013 - catalytic step 2 spliceosome

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

1258745

F10C1
Protein FRA10AC1

4

2

Small-scale

0.707

High

485705

RU2A
U2 small nuclear ribonucleoprotein A'

3

3

High-throughput

0.667

High

1286212

RALYL
RNA-binding Raly-like protein

3

3

High-throughput

0.667

High

1387423

PRP19
Pre-mRNA-processing factor 19

3

3

High-throughput

0.667

High

992906

RACK1
Small ribosomal subunit protein RACK1

1

3

High-throughput

0.656

High

1111182

SNW1
SNW domain-containing protein 1

1

0

High-throughput

0.656

High

372800

MYC
Myc proto-oncogene protein

3

1

High-throughput

0.640

High

50032

F170A
Protein FAM170A

3

0

High-throughput

0.638

High

1340497

DNJB8
DnaJ homolog subfamily B member 8

3

0

High-throughput

0.638

High

1387420

IKZF3
Zinc finger protein Aiolos

3

0

High-throughput

0.638

High

593001

ACADS
Short-chain specific acyl-CoA dehydrogenase, mitochondrial

3

0

High-throughput

0.634

High

537687

HSP7C
Heat shock cognate 71 kDa protein

2

1

High-throughput

0.628

High

1387416

NXF1
Nuclear RNA export factor 1

3

0

High-throughput

0.625

High

1048056

TLE3
Transducin-like enhancer protein 3

1

2

High-throughput

0.618

High

974178

RUXG
Small nuclear ribonucleoprotein G

2

2

High-throughput

0.611

High

1387390

SMRD1
SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily D member 1

2

1

High-throughput

0.606

High

351344

SYF2
Pre-mRNA-splicing factor SYF2

2

0

High-throughput

0.602

High

973789

RUXE
Small nuclear ribonucleoprotein E

2

0

High-throughput

0.602

High

991222

RSMN
Small nuclear ribonucleoprotein-associated protein N

2

0

High-throughput

0.602

High

569265

YJU2B
Probable splicing factor YJU2B

2

1

High-throughput

0.601

High

1387388

SNR40
U5 small nuclear ribonucleoprotein 40 kDa protein

1

0

High-throughput

0.586

High

1387397

USB1
U6 snRNA phosphodiesterase 1

2

0

High-throughput

0.585

High

386071

LMNA
Prelamin-A/C [Cleaved into: Lamin-A/C

2

2

High-throughput

0.584

High

217176

MS18B
Protein Mis18-beta

2

0

High-throughput

0.580

High

1120872

DGCR6
Protein DGCR6

2

0

High-throughput

0.580

High

251026

PRP17
Pre-mRNA-processing factor 17

1

3

High-throughput

0.575

High

873482

PP2BC
Serine/threonine-protein phosphatase 2B catalytic subunit gamma isoform

2

2

High-throughput

0.574

High

861719

NEDD4
E3 ubiquitin-protein ligase NEDD4

2

1

High-throughput

0.571

High

414382

P53
Cellular tumor antigen p53

2

0

High-throughput

0.559

High

981003

H2B1C
Histone H2B type 1-C/E/F/G/I

2

0

High-throughput

0.559

High

1346883

SNIP1
Smad nuclear-interacting protein 1

2

0

High-throughput

0.547

High

474886

VIME
Vimentin

2

1

High-throughput

0.543

High

256663

HNRC1
Heterogeneous nuclear ribonucleoprotein C-like 1

1

3

High-throughput

0.536

High

462560

HNRPC
Heterogeneous nuclear ribonucleoproteins C1/C2

1

4

High-throughput

0.536

High

682573

S100P
Protein S100-P

1

2

High-throughput

0.536

High

686851

S10A4
Protein S100-A4

1

2

High-throughput

0.536

High

931050

HSP72
Heat shock-related 70 kDa protein 2

1

1

High-throughput

0.536

High

1138497

U5S1
116 kDa U5 small nuclear ribonucleoprotein component

1

1

High-throughput

0.536

High

1387396

LYST
Lysosomal-trafficking regulator

1

0

Small-scale

0.519

High

964703

DCAF7
DDB1- and CUL4-associated factor 7

1

1

High-throughput

0.514

High

298046

SPF27
Pre-mRNA-splicing factor SPF27

1

0

High-throughput

0.513

High

553038

PIP
Prolactin-inducible protein

1

0

High-throughput

0.513

High

625552

CSK22
Casein kinase II subunit alpha'

1

0

High-throughput

0.513

High

1099753

MD2L1
Mitotic spindle assembly checkpoint protein MAD2A

1

0

High-throughput

0.513

High

1168860

HNRL2
Heterogeneous nuclear ribonucleoprotein U-like protein 2

1

0

High-throughput

0.513

High

1293393

CARM1
Histone-arginine methyltransferase CARM1

1

0

High-throughput

0.513

High

1387401

DUS16
Dual specificity protein phosphatase 16

1

0

High-throughput

0.513

High

1387407

HINT3
Adenosine 5'-monophosphoramidase HINT3

1

0

High-throughput

0.513

High

1387415

FOXJ2
Forkhead box protein J2

1

0

High-throughput

0.513

High

1387422

ISY1
Pre-mRNA-splicing factor ISY1 homolog

1

0

High-throughput

0.513

High

1387424

PPIE
Peptidyl-prolyl cis-trans isomerase E

1

0

High-throughput

0.513

High

1387431

TSSC4
U5 small nuclear ribonucleoprotein TSSC4

1

0

High-throughput

0.513

High

238934

DHX16
Pre-mRNA-splicing factor ATP-dependent RNA helicase DHX16

1

2

High-throughput

0.508

High

1387399

RBM4
RNA-binding protein 4

1

2

High-throughput

0.508

High

862363

YAP1
Transcriptional coactivator YAP1

1

3

High-throughput

0.501

High

706255

S10A2
Protein S100-A2

1

2

High-throughput

0.489

High

1016553

SRSF3
Serine/arginine-rich splicing factor 3

1

1

High-throughput

0.489

High

1387408

DJC17
DnaJ homolog subfamily C member 17

1

1

High-throughput

0.489

High

1387414

HPBP1
Hsp70-binding protein 1

1

2

High-throughput

0.489

High

1137653

EXOS7
Exosome complex component RRP42

1

1

High-throughput

0.481

High

1387393

EHMT2
Histone-lysine N-methyltransferase EHMT2

1

2

High-throughput

0.481

High

1387409

RBM22
Pre-mRNA-splicing factor RBM22

1

1

High-throughput

0.481

High

185918

OGT1
UDP-N-acetylglucosamine--peptide N-acetylglucosaminyltransferase 110 kDa subunit

1

0

High-throughput

0.480

High

173204

XPO1
Exportin-1

1

1

High-throughput

0.479

High

406477

MYCN
N-myc proto-oncogene protein

1

1

High-throughput

0.479

High

998662

H31
Histone H3.1

1

1

High-throughput

0.479

High

1017099

H33
Histone H3.3

1

1

High-throughput

0.479

High

1128080

DHX8
ATP-dependent RNA helicase DHX8

1

2

High-throughput

0.479

High

1311828

DHX40
Probable ATP-dependent RNA helicase DHX40

1

2

High-throughput

0.479

High

1351119

SP7
Transcription factor Sp7

1

1

High-throughput

0.479

High

1369814

CELF1
CUGBP Elav-like family member 1

1

1

High-throughput

0.479

High

1387413

WWOX
WW domain-containing oxidoreductase

1

1

High-throughput

0.479

High

1387418

XPO7
Exportin-7

1

1

High-throughput

0.479

High

570545

GFAP
Glial fibrillary acidic protein

1

1

High-throughput

0.470

High

1387394

TTC14
Tetratricopeptide repeat protein 14

1

1

High-throughput

0.464

High

1329074

CPSF7
Cleavage and polyadenylation specificity factor subunit 7

1

0

High-throughput

0.460

High

1387389

THOC1
THO complex subunit 1

1

0

High-throughput

0.460

High

1387392

CK5P3
CDK5 regulatory subunit-associated protein 3

1

0

High-throughput

0.460

High

1387425

TRAK1
Trafficking kinesin-binding protein 1

1

0

High-throughput

0.460

High

170274

AURKA
Aurora kinase A

1

0

High-throughput

0.458

High

337382

PARN
Poly(A)-specific ribonuclease PARN

1

0

High-throughput

0.458

High

589377

RFA2
Replication protein A 32 kDa subunit

1

0

High-throughput

0.458

High

652562

NR4A1
Nuclear receptor subfamily 4immunitygroup A member 1

1

0

Small-scale

0.458

High

696178

RFA1
Replication protein A 70 kDa DNA-binding subunit

1

0

High-throughput

0.458

High

714341

PML
Protein PML

1

0

High-throughput

0.458

High

800034

COIL
Coilin

1

0

High-throughput

0.458

High

831219

CCNF
Cyclin-F

1

0

High-throughput

0.458

High

879351

NR2C2
Nuclear receptor subfamily 2 group C member 2

1

0

High-throughput

0.458

High

887104

CEBPA
CCAAT/enhancer-binding protein alpha

1

0

High-throughput

0.458

High

934986

TERA
Transitional endoplasmic reticulum ATPase

1

0

High-throughput

0.458

High

991901

DYLT1
Dynein light chain Tctex-type 1

1

0

High-throughput

0.458

High

1033132

EWS
RNA-binding protein EWS

1

0

High-throughput

0.458

High

1097477

CBX3
Chromobox protein homolog 3

1

0

High-throughput

0.458

High

1276623

PARPT
Protein mono-ADP-ribosyltransferase TIPARP

1

0

High-throughput

0.458

High

1363937

SMG7
Nonsense-mediated mRNA decay factor SMG7

1

0

High-throughput

0.458

High

1368045

HDAC2
Histone deacetylase 2

1

0

High-throughput

0.458

High

1387395

CDC5L
Cell division cycle 5-like protein

1

0

High-throughput

0.458

High

1387400

KLF16
Krueppel-like factor 16

1

0

High-throughput

0.458

High

1387403

UBE2O
(E3-independent) E2 ubiquitin-conjugating enzyme

1

0

High-throughput

0.458

High

1387406

EGLN3
Prolyl hydroxylase EGLN3

1

0

High-throughput

0.458

High

1387411

TE2IP
Telomeric repeat-binding factor 2-interacting protein 1

1

0

High-throughput

0.458

High

1387417

ZRAN1
Ubiquitin thioesterase ZRANB1

1

0

High-throughput

0.458

High

1387426

ASF1A
Histone chaperone ASF1A

1

0

High-throughput

0.458

High

1387430

ZN330
Zinc finger protein 330

1

0

High-throughput

0.458

High

71601

RUXGL
Putative small nuclear ribonucleoprotein G-like protein 15

1

2

High-throughput

0.445

High

1387402

CRNL1
Crooked neck-like protein 1

1

2

High-throughput

0.445

High

1206513

PRC2B
Protein PRRC2B

1

1

High-throughput

0.439

High

1387412

UTP6
U3 small nucleolar RNA-associated protein 6 homolog

1

2

High-throughput

0.439

High

1387404

Q9H4D1
Receptor-interacting serine/threonine-protein kinase 4

1

1

High-throughput

0.437

High

344278

PTBP3
Polypyrimidine tract-binding protein 3

1

0

High-throughput

0.426

High

1108803

ASAH1
Acid ceramidase

1

0

High-throughput

0.426

High

1311152

UBR2
E3 ubiquitin-protein ligase UBR2

1

0

High-throughput

0.426

High

1387410

PP4R2
Serine/threonine-protein phosphatase 4 regulatory subunit 2

1

0

High-throughput

0.426

High

593863

PP2BB
Serine/threonine-protein phosphatase 2B catalytic subunit beta isoform

1

2

High-throughput

0.407

High

944027

RIPK4
Receptor-interacting serine/threonine-protein kinase 4

1

1

High-throughput

0.407

High

1062390

PP2BA
Protein phosphatase 3 catalytic subunit alpha

1

2

High-throughput

0.407

High

1309475

CEP97
Centrosomal protein of 97 kDa

1

3

High-throughput

0.407

High

1387427

NISCH
Nischarin

1

1

High-throughput

0.407

High

1387391

ITCH
E3 ubiquitin-protein ligase Itchy homolog

1

1

High-throughput

0.373

High

1385244

LENG1
Leukocyte receptor cluster member 1

3

0

High-throughput

0.347

High

932412

GALC
Galactocerebrosidase

3

0

High-throughput

0.345

High

989917

CANB1
Calcineurin subunit B type 1

3

0

High-throughput

0.345

High

1090272

ELAV2
ELAV-like protein 2

2

0

High-throughput

0.328

High

1256713

NKAP1
Uncharacterized protein NKAPD1

2

0

High-throughput

0.328

High

868227

SYQ
Glutamine--tRNA ligase

2

0

High-throughput

0.316

High

1180002

CCD57
Coiled-coil domain-containing protein 57

2

0

High-throughput

0.316

High

1315113

EXOC8
Exocyst complex component 8

2

0

High-throughput

0.316

High

1387405

ARMC7
Armadillo repeat-containing protein 7

2

0

High-throughput

0.316

High

1309670

ARHGJ
Rho guanine nucleotide exchange factor 19

2

0

High-throughput

0.298

High

347238

BAG2
BAG family molecular chaperone regulator 2

1

0

High-throughput

0.279

Low

692775

CALL3
Calmodulin-like protein 3

1

0

High-throughput

0.279

Low

1178861

CF184
Cilia- and flagella-associated protein 184

1

0

High-throughput

0.279

Low

1360711

JPH3
Junctophilin-3

1

0

High-throughput

0.268

Low

261853

PFD1
Prefoldin subunit 1

1

0

High-throughput

0.265

Low

388548

CRP

1

0

High-throughput

0.251

Low

1146093

K1H1
Keratin, type I cuticular Ha1

1

0

High-throughput

0.251

Low

1198489

CEP55
Centrosomal protein of 55 kDa

1

0

High-throughput

0.251

Low

1217829

PR38B
Pre-mRNA-splicing factor 38B

1

0

High-throughput

0.251

Low

1387419

HOOK1
Protein Hook homolog 1

1

0

High-throughput

0.251

Low

1387429

WNK2
Serine/threonine-protein kinase WNK2

1

0

High-throughput

0.251

Low

106436

APRIO
Alternative prion protein

1

0

High-throughput

0.249

Low

768858

RFA3
Replication protein A 14 kDa subunit

1

0

High-throughput

0.249

Low

942817

BCAR1
Breast cancer anti-estrogen resistance protein 1

1

0

High-throughput

0.249

Low

1289263

DTX2
Probable E3 ubiquitin-protein ligase DTX2

1

0

High-throughput

0.249

Low

1314354

SLX4
Structure-specific endonuclease subunit SLX4

1

0

High-throughput

0.249

Low

1384843

CHCH1
Small ribosomal subunit protein mS37

1

0

High-throughput

0.249

Low

1386765

GCP3
Gamma-tubulin complex component 3

1

0

High-throughput

0.249

Low

1387398

CP250
Centrosome-associated protein CEP250

1

0

High-throughput

0.249

Low

1387421

NUP50
Nuclear pore complex protein Nup50

1

0

High-throughput

0.249

Low

848056

AL3B1
Aldehyde dehydrogenase family 3 member B1

1

0

High-throughput

0.232

Low

1208191

P4R3B
Serine/threonine-protein phosphatase 4 regulatory subunit 3B

1

0

High-throughput

0.232

Low

1219871

OBI1
ORC ubiquitin ligase 1

1

0

High-throughput

0.232

Low

1253920

FA83H
Protein FAM83H

1

0

High-throughput

0.232

Low

1308826

P3H2
Prolyl 3-hydroxylase 2

1

0

High-throughput

0.232

Low

1339806

TRI58
E3 ubiquitin-protein ligase TRIM58

1

0

High-throughput

0.232

Low

1387428

SYYM
Tyrosine--tRNA ligase, mitochondrial

1

0

High-throughput

0.232

Low


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Last updated: 11Aug2025