HitPredict

Interactor 1: P53 (P04637)
Cellular tumor antigen p53 (Antigen NY-CO-13) (Phosphoprotein p53) (Tumor suppressor p53)
Gene: TP53

Interactor 2: FLNA (P21333)
Filamin-A (FLN-A) (Actin-binding protein 280) (ABP-280) (Alpha-filamin) (Endothelial actin-binding protein) (Filamin-1) (Non-muscle filamin)
Gene: FLNA

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.60	0.60	0.601

Property	Details
Experiments	25144556, 32814053
Identification Methods	affinity chromatography technology, two hybrid array, two hybrid pooling approach, validated two hybrid
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus GO:0005730 - nucleolus GO:0005737 - cytoplasm GO:0005829 - cytosol GO:0043066 - negative regulation of apoptotic process and 1 others more... GO:0050821 - protein stabilization
Homologous interactions	5

Homologous interactions

Color coding for hit scores

	1 393 Hs			1 2647
+	Hs
		261176 P53_HUMAN (1-393): 0: 619: 100.00		FLNB_HUMAN (28-2647): 0: 2710: 69.63
+	Hs
		175822 P73_HUMAN (13-362): 2.35e-166: 481: 39.74		FLNA_HUMAN (1-2647): 0: 2776: 100.00
+	Hs
		1052936 P63_HUMAN (28-363): 2.35e-145: 429: 42.11		FLNC_HUMAN (32-2647): 0: 1432: 35.96
+	Hs
		386541 P53_HUMAN (1-393): 0: 619: 100.00		SPTB2_HUMAN (22-460): 2.2e-118: 423: 24.62
+	Hs
		211459 P53_HUMAN (1-393): 0: 619: 100.00		ACTN4_HUMAN (23-382): 4.2e-112: 383: 27.01