HitPredict

Interactor 1: P53 (P04637)
Cellular tumor antigen p53 (Antigen NY-CO-13) (Phosphoprotein p53) (Tumor suppressor p53)
Gene: TP53

Interactor 2: S10AB (P31949)
Protein S100-A11 (Calgizzarin) (Metastatic lymph node gene 70 protein) (MLN 70) (Protein S100-C) (S100 calcium-binding protein A11) [Cleaved into: Protein S100-A11, N-terminally processed]
Gene: S100A11

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.41	1.00	0.647

Property	Details
Experiments	31837246
Identification Methods	fluorescence polarization spectroscopy
Interaction Type	direct interaction

Property	Details
Interacting Pfam domains	S_100~TAD2
Common GO terms	GO:0005634 - nucleus GO:0005737 - cytoplasm GO:0008156 - negative regulation of DNA replication GO:0008285 - negative regulation of cell population proliferation
Homologous interactions	16

Homologous interactions

Color coding for hit scores

	1 393 Hs			1 105
+	Hs
		386104 P53_HUMAN (1-393): 0: 619: 100.00		S10A1_HUMAN (8-99): 6.47e-39: 126: 41.30
+	Hs
		387043 P53_HUMAN (1-393): 0: 619: 100.00		HORN_HUMAN (9-104): 4.97e-34: 125: 27.00
+	Hs
		386412 P53_HUMAN (1-393): 0: 619: 100.00		S10AA_HUMAN (7-104): 1.06e-37: 123: 36.74
+	Hs
		386132 P53_HUMAN (1-393): 0: 619: 100.00		S100P_HUMAN (8-98): 1.04e-36: 121: 40.66
+	Hs
		386137 P53_HUMAN (1-393): 0: 619: 100.00		S10A4_HUMAN (9-103): 6.62e-35: 116: 28.42
+	Hs
		386155 P53_HUMAN (1-393): 0: 619: 100.00		S10A2_HUMAN (8-102): 6.11e-34: 114: 30.53
+	Hs
		386865 P53_HUMAN (1-393): 0: 619: 100.00		FILA2_HUMAN (8-103): 1.76e-29: 112: 40.00
+	Hs
		380714 P53_HUMAN (1-393): 0: 619: 100.00		S100B_HUMAN (8-95): 7.04e-33: 111: 36.36
+	Hs
		386192 P53_HUMAN (1-393): 0: 619: 100.00		S10A3_HUMAN (9-102): 4e-32: 109: 31.92
+	Hs
		386512 P53_HUMAN (1-393): 0: 619: 100.00		S10AC_HUMAN (8-98): 8.18e-32: 108: 36.26
+	Hs
		385910 P53_HUMAN (1-393): 0: 619: 100.00		S10A8_HUMAN (8-102): 9.02e-30: 103: 26.32
+	Hs
		385924 P53_HUMAN (1-393): 0: 619: 100.00		S10A6_HUMAN (9-95): 2.4e-27: 97.3: 32.18
+	Hs
		387288 P53_HUMAN (1-393): 0: 619: 100.00		S10AG_HUMAN (8-101): 4.75e-27: 97.3: 25.26
+	Hs
		386191 P53_HUMAN (1-393): 0: 619: 100.00		S10A5_HUMAN (8-100): 3.68e-27: 96.9: 32.26
+	Hs
		387371 P53_HUMAN (1-393): 0: 619: 100.00		S10AD_HUMAN (8-89): 2.97e-24: 90: 39.02
+	Hs
		386596 P53_HUMAN (1-393): 0: 619: 100.00		TRHY_HUMAN (8-100): 3.69e-21: 88.4: 27.96