Protein: CO8A1
Collagen alpha-1(VIII) chain (Endothelial collagen) [Cleaved into: Vastatin]

Gene: CO8A1, COL8A1
Organism: Homo sapiens
Interactions: 138
UniProt ID: P27658

Gene Ontology (top 5):
GO:0001525 - angiogenesis
GO:0001935 - endothelial cell proliferation
GO:0005576 - extracellular region
GO:0005591 - collagen type VIII trimer
GO:0005615 - extracellular space

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

384245

CO2A1
Collagen alpha-1(II) chain

1

19

High-throughput

0.691

High

384307

CO4A1

1

18

High-throughput

0.691

High

635446

CO5A1

1

19

High-throughput

0.691

High

694312

COIA1
Collagen alpha-1(XVIII) chain [Cleaved into: Endostatin; Non-collagenous domain 1

1

19

High-throughput

0.691

High

694367

C1QL4
Complement C1q-like protein 4

1

20

High-throughput

0.691

High

668772

CO8A2
Collagen alpha-2(VIII) chain

1

19

Small-scale

0.647

High

694331

VAC14
Protein VAC14 homolog

4

2

High-throughput

0.644

High

694366

NT2NA
Notch homolog 2 N-terminal-like protein A

2

2

High-throughput

0.633

High

694322

KR108
Keratin-associated protein 10-8

3

6

High-throughput

0.616

High

694327

CREB5
Cyclic AMP-responsive element-binding protein 5

3

2

High-throughput

0.616

High

694313

LIMS1
LIM and senescent cell antigen-like-containing domain protein 1

2

1

High-throughput

0.606

High

694316

CCN3
CCN family member 3

2

1

High-throughput

0.606

High

694325

FBLN2
Fibulin-2

2

3

High-throughput

0.606

High

191296

P4HA2
Prolyl 4-hydroxylase subunit alpha-2

2

14

High-throughput

0.601

High

694376

WFDC5
WAP four-disulfide core domain protein 5

2

0

High-throughput

0.580

High

694398

BPIA1
BPI fold-containing family A member 1

2

0

High-throughput

0.580

High

694328

COAA1

1

18

High-throughput

0.575

High

694336

ADIPO
Adiponectin

1

20

High-throughput

0.575

High

694362

ATL4
ADAMTS-like protein 4

1

2

High-throughput

0.560

High

192359

GSC2
Homeobox protein goosecoid-2

2

5

High-throughput

0.553

High

300112

GLRX3
Glutaredoxin-3

2

10

High-throughput

0.553

High

300631

KRT37
Keratin, type I cuticular Ha7

2

2

High-throughput

0.553

High

685810

KRA59
Keratin-associated protein 5-9

2

8

High-throughput

0.553

High

694311

OTX1
Homeobox protein OTX1

2

3

High-throughput

0.553

High

694343

KR133
Keratin-associated protein 13-3

2

1

High-throughput

0.553

High

694355

KRA57
Keratin-associated protein 5-7

2

7

High-throughput

0.553

High

694358

ZN774
Zinc finger protein 774

2

2

High-throughput

0.553

High

694369

KRA13
Keratin-associated protein 1-3

2

6

High-throughput

0.553

High

694381

ARMC5
Armadillo repeat-containing protein 5

2

1

High-throughput

0.553

High

694390

KRA93
Keratin-associated protein 9-3

2

7

High-throughput

0.553

High

694412

CIDEB
Lipid transferase CIDEB

2

1

High-throughput

0.553

High

694413

UBQL2
Ubiquilin-2

2

6

High-throughput

0.553

High

694417

TRI35
E3 ubiquitin-protein ligase TRIM35

2

1

High-throughput

0.553

High

351504

FBLN4
EGF-containing fibulin-like extracellular matrix protein 2

1

5

High-throughput

0.541

High

291988

CRTAP
Cartilage-associated protein

1

16

High-throughput

0.536

High

566916

P4HA1
Prolyl 4-hydroxylase subunit alpha-1

1

14

High-throughput

0.536

High

694334

ELOA1
Elongin-A

1

3

High-throughput

0.536

High

694337

P3H1
Prolyl 3-hydroxylase 1

1

16

High-throughput

0.536

High

694370

GT252
Procollagen galactosyltransferase 2

1

20

High-throughput

0.536

High

694321

KR107
Keratin-associated protein 10-7

1

6

High-throughput

0.523

High

694326

SP4
Transcription factor Sp4

1

3

High-throughput

0.523

High

694329

REL
Proto-oncogene c-Rel

1

2

High-throughput

0.523

High

694352

K1C40
Keratin, type I cytoskeletal 40

1

2

High-throughput

0.523

High

694391

KRA92
Keratin-associated protein 9-2

1

7

High-throughput

0.523

High

516969

NT2NC
Notch homolog 2 N-terminal-like protein C

1

2

High-throughput

0.515

High

694348

HABP4
Intracellular hyaluronan-binding protein 4

1

0

High-throughput

0.513

High

694396

ESF1
ESF1 homolog

1

0

High-throughput

0.513

High

694346

KLH12
Kelch-like protein 12

1

7

High-throughput

0.494

High

694387

KR412
Keratin-associated protein 4-12

1

7

High-throughput

0.494

High

694401

UBQL4
Ubiquilin-4

1

6

High-throughput

0.494

High

143801

NDKM
Nucleoside diphosphate kinase, mitochondrial

1

3

High-throughput

0.489

High

694315

PRC2A
Protein PRRC2A

1

5

High-throughput

0.489

High

694365

DDX46
Probable ATP-dependent RNA helicase DDX46

1

2

High-throughput

0.489

High

694386

IWS1
Protein IWS1 homolog

1

2

High-throughput

0.489

High

694389

DIDO1
Death-inducer obliterator 1

1

17

High-throughput

0.489

High

694400

DISC1
Disrupted in schizophrenia 1 protein

1

5

High-throughput

0.489

High

694419

WBP11
WW domain-binding protein 11

1

3

High-throughput

0.489

High

694377

SRB4D
Scavenger receptor cysteine-rich domain-containing group B protein

1

2

High-throughput

0.481

High

389059

FINC
Fibronectin

1

20

Small-scale

0.479

High

694388

Q9BS75
Kelch-like protein 20

1

18

High-throughput

0.470

High

128791

MEN1
Menin

1

0

High-throughput

0.458

High

469663

MMP2
72 kDa type IV collagenase

1

20

High-throughput

0.445

High

694354

LAIR2
Leukocyte-associated immunoglobulin-like receptor 2

1

15

High-throughput

0.445

High

484

NBPFJ
NBPF family member NBPF19

1

1

High-throughput

0.439

High

694320

KR103
Keratin-associated protein 10-3

1

7

High-throughput

0.439

High

694368

KR131
Keratin-associated protein 13-1

1

1

High-throughput

0.439

High

694418

KLH20
Kelch-like protein 20

1

8

High-throughput

0.439

High

105386

APRIO
Alternative prion protein

1

11

High-throughput

0.437

High

371223

MYC
Myc proto-oncogene protein

1

1

High-throughput

0.437

High

694314

SOX2
Transcription factor SOX-2

1

2

High-throughput

0.437

High

694351

RN123
E3 ubiquitin-protein ligase RNF123

1

2

High-throughput

0.437

High

694363

MOB3C
MOB kinase activator 3C

1

1

High-throughput

0.437

High

694335

SF01
Splicing factor 1

1

1

High-throughput

0.417

High

694332

INCA1
Protein INCA1

4

0

High-throughput

0.364

High

303106

RGS20
Regulator of G-protein signaling 20

3

0

High-throughput

0.339

High

70123

CRTP1
Cysteine-rich tail protein 1

2

0

High-throughput

0.316

High

211624

ZNHI1
Zinc finger HIT domain-containing protein 1

2

0

High-throughput

0.316

High

220224

FRS3
Fibroblast growth factor receptor substrate 3

2

0

High-throughput

0.316

High

694317

HXA1
Homeobox protein Hox-A1

2

0

High-throughput

0.316

High

694319

KR123
Keratin-associated protein 12-3

2

0

High-throughput

0.316

High

694324

S35A2
UDP-galactose translocator

2

0

High-throughput

0.316

High

694333

PO4F2
POU domain, class 4, transcription factor 2

2

0

High-throughput

0.316

High

694338

MAJIN
Membrane-anchored junction protein

2

0

High-throughput

0.316

High

694339

KR192
Keratin-associated protein 19-2

2

0

High-throughput

0.316

High

694340

KRA62
Keratin-associated protein 6-2

2

0

High-throughput

0.316

High

694342

KR195
Keratin-associated protein 19-5

2

0

High-throughput

0.316

High

694344

KR197
Keratin-associated protein 19-7

2

0

High-throughput

0.316

High

694345

CEP55
Centrosomal protein of 55 kDa

2

0

High-throughput

0.316

High

694347

ACTMP
Actin maturation protease

2

0

High-throughput

0.316

High

694350

KPRP
Keratinocyte proline-rich protein

2

0

High-throughput

0.316

High

694353

NADE
Glutamine-dependent NAD(+) synthetase

2

0

High-throughput

0.316

High

694356

KRA56
Keratin-associated protein 5-6

2

0

High-throughput

0.316

High

694357

RHBD2
Rhomboid domain-containing protein 2

2

0

High-throughput

0.316

High

694359

CV039
Synaptic plasticity regulator PANTS

2

0

High-throughput

0.316

High

694361

SPAT8
Spermatogenesis-associated protein 8

2

0

High-throughput

0.316

High

694372

SMIP6
Sperm microtubule inner protein 6

2

0

High-throughput

0.316

High

694379

POF1B
Protein POF1B

2

0

High-throughput

0.316

High

694380

RBPMS
RNA-binding protein with multiple splicing

2

0

High-throughput

0.316

High

694392

KRA32
Keratin-associated protein 3-2

2

0

High-throughput

0.316

High

694394

SPY4
Protein sprouty homolog 4

2

0

High-throughput

0.316

High

694397

CFA68
Cilia- and flagella-associated protein 68

2

0

High-throughput

0.316

High

694402

PLS3
Phospholipid scramblase 3

2

0

High-throughput

0.316

High

694403

KRT82
Keratin, type II cuticular Hb2

2

0

High-throughput

0.316

High

694407

F86C1
Putative protein FAM86C1P

2

0

High-throughput

0.316

High

694408

FBX34
F-box only protein 34

2

0

High-throughput

0.316

High

694360

KR261
Keratin-associated protein 26-1

1

0

High-throughput

0.303

High

66580

CC85C
Coiled-coil domain-containing protein 85C

1

0

High-throughput

0.279

Low

569058

T2FB
General transcription factor IIF subunit 2

1

0

High-throughput

0.279

Low

694349

ZC3HD
Zinc finger CCCH domain-containing protein 13

1

0

High-throughput

0.279

Low

694364

CENPU
Centromere protein U

1

0

High-throughput

0.279

Low

694371

NF2IP
NFATC2-interacting protein

1

0

High-throughput

0.279

Low

694373

LS14A
Protein LSM14 homolog A

1

0

High-throughput

0.279

Low

694374

RP9
Retinitis pigmentosa 9 protein

1

0

High-throughput

0.279

Low

694375

SNIP1
Smad nuclear-interacting protein 1

1

0

High-throughput

0.279

Low

694378

SNR27
U4/U6.U5 small nuclear ribonucleoprotein 27 kDa protein

1

0

High-throughput

0.279

Low

694382

REPS1
RalBP1-associated Eps domain-containing protein 1

1

0

High-throughput

0.279

Low

694383

RMXL1
RNA binding motif protein, X-linked-like-1

1

0

High-throughput

0.279

Low

694384

RRP36
Ribosomal RNA processing protein 36 homolog

1

0

High-throughput

0.279

Low

694385

ZC21A
Zinc finger C2HC domain-containing protein 1A

1

0

High-throughput

0.279

Low

694393

GTPB4
GTP-binding protein 4

1

0

High-throughput

0.279

Low

694395

LSG1
Large subunit GTPase 1 homolog

1

0

High-throughput

0.279

Low

694404

SLX9
Ribosome biogenesis protein SLX9 homolog

1

0

High-throughput

0.279

Low

694405

BMP2K
BMP-2-inducible protein kinase

1

0

High-throughput

0.279

Low

694406

DCA13
DDB1- and CUL4-associated factor 13

1

0

High-throughput

0.279

Low

694409

CWC25
Pre-mRNA-splicing factor CWC25 homolog

1

0

High-throughput

0.279

Low

694410

M3K20
Mitogen-activated protein kinase kinase kinase 20

1

0

High-throughput

0.279

Low

694411

ZO2
Tight junction protein 2

1

0

High-throughput

0.279

Low

694416

NOB1
RNA-binding protein NOB1

1

0

High-throughput

0.279

Low

446673

NPM
Nucleophosmin

1

0

High-throughput

0.269

Low

3657

DP2NB
DPEP2 neighbor protein

1

0

High-throughput

0.268

Low

694341

KRA63
Keratin-associated protein 6-3

1

0

High-throughput

0.268

Low

694323

YPEL3
Protein yippee-like 3

1

0

High-throughput

0.251

Low

694330

PPARA
Peroxisome proliferator-activated receptor alpha

1

0

High-throughput

0.251

Low

694318

MCM2
DNA replication licensing factor MCM2

1

0

High-throughput

0.249

Low

694415

BAG5
BAG family molecular chaperone regulator 5

1

0

High-throughput

0.249

Low

261768

PFD1
Prefoldin subunit 1

1

0

High-throughput

0.232

Low

694399

PFD4
Prefoldin subunit 4

1

0

High-throughput

0.232

Low

694414

PFD2
Prefoldin subunit 2

1

0

High-throughput

0.232

Low


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Last updated: 11Aug2025