HitPredict

Interactor 1: P53 (P04637)
Cellular tumor antigen p53 (Antigen NY-CO-13) (Phosphoprotein p53) (Tumor suppressor p53)
Gene: TP53

Interactor 2: UBE2A (P49459)
Ubiquitin-conjugating enzyme E2 A (EC 2.3.2.23) (E2 ubiquitin-conjugating enzyme A) (RAD6 homolog A) (HR6A) (hHR6A) (Ubiquitin carrier protein A) (Ubiquitin-protein ligase A)
Gene: UBE2A

Species: Homo sapiens

Source: dip

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.81	0.60	0.700

Property	Details
Experiments	28031328, 12640129, 22083959, 24506068
Identification Methods	affinity chromatography technology, pull down, surface plasmon resonance, coimmunoprecipitation, fluorescence microscopy
Interaction Type	physical association, direct interaction

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0000785 - chromatin GO:0005654 - nucleoplasm GO:0005829 - cytosol GO:0031625 - ubiquitin protein ligase binding
Homologous interactions	3

Homologous interactions

Color coding for hit scores

	1 393 Hs			1 152
+	Hs
		386463 P53_HUMAN (1-393): 0: 619: 100.00		UB2D2_HUMAN (5-149): 7.73e-78: 229: 38.62
+	Hs
		386483 P53_HUMAN (1-393): 0: 619: 100.00		UBE2B_HUMAN (1-151): 3.28e-74: 219: 96.03
+	Dm
		627011 Q9N6D8_DROME (124-325): 3.11e-77: 245: 24.31		UBCD6_DROME (1-148): 1.44e-75: 223: 89.19