Protein: K2C75
Keratin, type II cytoskeletal 75 (Cytokeratin-75) (CK-75) (Keratin-6 hair follicle) (hK6hf) (Keratin-75) (K75) (Type II keratin-K6hf) (Type-II keratin Kb18)

Gene: K2C75, KRT75
Organism: Homo sapiens
Interactions: 192
UniProt ID: O95678

Gene Ontology (top 5):
GO:0001533 - cornified envelope
GO:0002244 - hematopoietic progenitor cell differentiation
GO:0005198 - structural molecule activity
GO:0005829 - cytosol
GO:0005882 - intermediate filament

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

341725

VIME
Vimentin

3

20

High-throughput

0.843

High

341726

K1C19
Keratin, type I cytoskeletal 19

3

20

High-throughput

0.843

High

341729

K2C3
Keratin, type II cytoskeletal 3

3

20

High-throughput

0.843

High

341735

DESM
Desmin

3

20

High-throughput

0.843

High

341736

K1C15
Keratin, type I cytoskeletal 15

3

20

High-throughput

0.843

High

341740

K1C20
Keratin, type I cytoskeletal 20

3

20

High-throughput

0.843

High

341747

PERI
Peripherin

3

20

High-throughput

0.843

High

341757

K22O
Keratin, type II cytoskeletal 2 oral

3

20

High-throughput

0.843

High

341724

K2C8
Keratin, type II cytoskeletal 8

3

20

High-throughput

0.827

High

300277

KRT34
Keratin, type I cuticular Ha4

2

20

High-throughput

0.794

High

300540

KRT36
Keratin, type I cuticular Ha6

2

20

High-throughput

0.783

High

300615

KRT37
Keratin, type I cuticular Ha7

2

20

High-throughput

0.783

High

300713

KRT38
Keratin, type I cuticular Ha8

2

20

High-throughput

0.783

High

341732

K1C13
Keratin, type I cytoskeletal 13

2

20

High-throughput

0.783

High

341771

KT33B
Keratin, type I cuticular Ha3-II

2

20

High-throughput

0.783

High

341775

K1H1
Keratin, type I cuticular Ha1

2

20

High-throughput

0.783

High

341779

K1C24
Keratin, type I cytoskeletal 24

2

20

High-throughput

0.783

High

341793

K1C40
Keratin, type I cytoskeletal 40

2

20

High-throughput

0.783

High

341798

K1C27
Keratin, type I cytoskeletal 27

2

20

High-throughput

0.783

High

341799

K1C26
Keratin, type I cytoskeletal 26

2

20

High-throughput

0.783

High

341800

K1C25
Keratin, type I cytoskeletal 25

2

20

High-throughput

0.783

High

341826

KRT35
Keratin, type I cuticular Ha5

2

20

High-throughput

0.783

High

341728

K1C16
Keratin, type I cytoskeletal 16

2

20

High-throughput

0.757

High

341723

K1C18
Keratin, type I cytoskeletal 18

2

20

High-throughput

0.754

High

341727

K2C7
Keratin, type II cytoskeletal 7

2

20

High-throughput

0.754

High

341868

WWOX
WW domain-containing oxidoreductase

3

1

High-throughput

0.653

High

341716

K2C75
Keratin, type II cytoskeletal 75

1

20

High-throughput

0.621

High

341772

K1H2
Keratin, type I cuticular Ha2

1

20

High-throughput

0.621

High

341718

K1C14
Keratin, type I cytoskeletal 14

1

20

High-throughput

0.618

High

341719

K2C6A
Keratin, type II cytoskeletal 6A

1

20

High-throughput

0.618

High

341721

K2C6B
Keratin, type II cytoskeletal 6B

1

20

High-throughput

0.618

High

341722

K2C1
Keratin, type II cytoskeletal 1

1

20

High-throughput

0.618

High

341731

K1C10
Keratin, type I cytoskeletal 10

1

20

High-throughput

0.618

High

341733

K2C5
Keratin, type II cytoskeletal 5

1

20

High-throughput

0.618

High

341741

K22E
Keratin, type II cytoskeletal 2 epidermal

1

20

High-throughput

0.618

High

341750

K2C6C
Keratin, type II cytoskeletal 6C

1

20

High-throughput

0.618

High

341758

K1C17
Keratin, type I cytoskeletal 17

1

20

High-throughput

0.618

High

341774

K2C72
Keratin, type II cytoskeletal 72

1

20

High-throughput

0.618

High

341780

K2C71
Keratin, type II cytoskeletal 71

1

20

High-throughput

0.618

High

341790

K2C79
Keratin, type II cytoskeletal 79

1

20

High-throughput

0.618

High

341801

K2C1B
Keratin, type II cytoskeletal 1b

1

20

High-throughput

0.618

High

341805

K2C73
Keratin, type II cytoskeletal 73

1

20

High-throughput

0.618

High

341840

K1C12
Keratin, type I cytoskeletal 12

1

20

High-throughput

0.618

High

341865

KRT84
Keratin, type II cuticular Hb4

1

20

High-throughput

0.618

High

163883

NDC80
Kinetochore protein NDC80 homolog

2

20

High-throughput

0.606

High

169371

HGS
Hepatocyte growth factor-regulated tyrosine kinase substrate

2

5

High-throughput

0.606

High

180198

RPAC1
DNA-directed RNA polymerases I and III subunit RPAC1

2

1

High-throughput

0.606

High

220835

XPOT
Exportin-T

2

5

High-throughput

0.606

High

276655

FKBP6
Inactive peptidyl-prolyl cis-trans isomerase FKBP6

2

2

High-throughput

0.606

High

329883

ZWINT
Outer kinetochore KNL1 complex subunit ZWINT

2

1

High-throughput

0.606

High

341720

SPTA1
Spectrin alpha chain, erythrocytic 1

2

6

High-throughput

0.606

High

341734

TRI27
Zinc finger protein RFP

2

5

High-throughput

0.606

High

341746

TXLNA
Alpha-taxilin

2

20

High-throughput

0.606

High

341752

CDN2D
Cyclin-dependent kinase 4 inhibitor D

2

4

High-throughput

0.606

High

341764

TRAF1
TNF receptor-associated factor 1

2

8

High-throughput

0.606

High

341777

CDC37
Hsp90 co-chaperone Cdc37

2

1

High-throughput

0.606

High

341778

LONF1
LON peptidase N-terminal domain and RING finger protein 1

2

6

High-throughput

0.606

High

341785

PKHG4
Puratrophin-1

2

2

High-throughput

0.606

High

341804

CEP57
Centrosomal protein of 57 kDa

2

4

High-throughput

0.606

High

341817

CCHCR
Coiled-coil alpha-helical rod protein 1

2

1

High-throughput

0.606

High

341823

ASB15
Ankyrin repeat and SOCS box protein 15

2

10

High-throughput

0.606

High

341830

MGN2
Protein mago nashi homolog 2

2

1

High-throughput

0.606

High

341831

FBX17
F-box only protein 17

2

1

High-throughput

0.606

High

341837

KCTD7
BTB/POZ domain-containing protein KCTD7

2

8

High-throughput

0.606

High

341839

SPAG5
Sperm-associated antigen 5

2

11

High-throughput

0.606

High

341844

TCHP
Trichoplein keratin filament-binding protein

2

9

High-throughput

0.606

High

341846

KIFC3
Kinesin-like protein KIFC3

2

8

High-throughput

0.606

High

341856

CARD9
Caspase recruitment domain-containing protein 9

2

3

High-throughput

0.606

High

341862

NEK6
Serine/threonine-protein kinase Nek6

2

2

High-throughput

0.606

High

341866

AIRIM
AFG2-interacting ribosome maturation factor

2

1

High-throughput

0.606

High

341867

ABI2
Abl interactor 2

2

13

High-throughput

0.606

High

341875

TRIM1
Probable E3 ubiquitin-protein ligase MID2

2

20

High-throughput

0.606

High

341879

KCC2A
Calcium/calmodulin-dependent protein kinase type II subunit alpha

2

2

High-throughput

0.606

High

341882

TNPO3
Transportin-3

2

6

High-throughput

0.606

High

341751

HNRPF
Heterogeneous nuclear ribonucleoprotein F

2

0

High-throughput

0.580

High

341806

GLCTK
Glycerate kinase

2

0

High-throughput

0.580

High

341814

MNS1
Meiosis-specific nuclear structural protein 1

2

0

High-throughput

0.580

High

341832

DTBP1
Dysbindin

2

0

High-throughput

0.580

High

341842

TS101
Tumor susceptibility gene 101 protein

2

0

High-throughput

0.580

High

341845

RPC3
DNA-directed RNA polymerase III subunit RPC3

2

0

High-throughput

0.580

High

341863

DMAP1
DNA methyltransferase 1-associated protein 1

2

0

High-throughput

0.580

High

341870

RCOR3
REST corepressor 3

2

0

High-throughput

0.580

High

341871

NCDN
Neurochondrin

2

0

High-throughput

0.580

High

341872

CPNE7
Copine-7

2

0

High-throughput

0.580

High

341878

SUFU
Suppressor of fused homolog

2

0

High-throughput

0.580

High

341881

NDK7
Nucleoside diphosphate kinase homolog 7

2

0

High-throughput

0.580

High

341744

NUP62
Nuclear pore glycoprotein p62

2

4

High-throughput

0.561

High

341874

RSP14
Radial spoke head 14 homolog

2

4

High-throughput

0.561

High

64997

GG6L9
Golgin subfamily A member 6-like protein 9

2

17

High-throughput

0.553

High

164502

TNPO2
Transportin-2

2

1

High-throughput

0.553

High

217033

MS18B
Protein Mis18-beta

2

5

High-throughput

0.553

High

337204

LCA5L
Lebercilin-like protein

2

2

High-throughput

0.553

High

341717

GPAN1
G patch domain and ankyrin repeat-containing protein 1

2

10

High-throughput

0.553

High

341737

RBTN2
Rhombotin-2

2

7

High-throughput

0.553

High

341738

RBTN1
Rhombotin-1

2

7

High-throughput

0.553

High

341742

TRI23
E3 ubiquitin-protein ligase TRIM23

2

3

High-throughput

0.553

High

341743

ZNF76
Zinc finger protein 76

2

2

High-throughput

0.553

High

341755

LMO4
LIM domain transcription factor LMO4

2

7

High-throughput

0.553

High

341759

CDK18
Cyclin-dependent kinase 18

2

1

High-throughput

0.553

High

341760

GOGA2
Golgin subfamily A member 2

2

5

High-throughput

0.553

High

341761

INCA1
Protein INCA1

2

1

High-throughput

0.553

High

341763

MKRN3
E3 ubiquitin-protein ligase makorin-3

2

1

High-throughput

0.553

High

341786

MTUS2
Microtubule-associated tumor suppressor candidate 2

2

11

High-throughput

0.553

High

341791

KANK2
KN motif and ankyrin repeat domain-containing protein 2

2

4

High-throughput

0.553

High

341792

C102B
Coiled-coil domain-containing protein 102B

2

2

High-throughput

0.553

High

341802

TBCD1
TBC1 domain family member 1

2

2

High-throughput

0.553

High

341807

CF206
Cilia- and flagella-associated protein 206

2

1

High-throughput

0.553

High

341809

TXLNB
Beta-taxilin

2

20

High-throughput

0.553

High

341810

USBP1
Harmonin-binding protein USHBP1

2

6

High-throughput

0.553

High

341811

TRIMM
Probable E3 ubiquitin-protein ligase TRIML2

2

5

High-throughput

0.553

High

341812

IQUB
IQ motif and ubiquitin-like domain-containing protein

2

1

High-throughput

0.553

High

341815

IKBD
NF-kappa-B inhibitor delta

2

4

High-throughput

0.553

High

341816

CA216
UPF0500 protein C1orf216

2

1

High-throughput

0.553

High

341821

TEKT4
Tektin-4

2

2

High-throughput

0.553

High

341829

TEKT1
Tektin-1

2

2

High-throughput

0.553

High

341835

GMCL1
Germ cell-less protein-like 1

2

1

High-throughput

0.553

High

341848

CAR10
Caspase recruitment domain-containing protein 10

2

14

High-throughput

0.553

High

341850

BEX2
Protein BEX2

2

1

High-throughput

0.553

High

341851

TRI54
Tripartite motif-containing protein 54

2

20

High-throughput

0.553

High

341861

KIF9
Kinesin-like protein KIF9

2

3

High-throughput

0.553

High

341880

WASC3
WASH complex subunit 3

2

2

High-throughput

0.553

High

341753

EPIPL
Epiplakin

1

19

High-throughput

0.536

High

341765

CUL1
Cullin-1

1

20

High-throughput

0.536

High

341766

CUL2
Cullin-2

1

20

High-throughput

0.536

High

341767

CUL3
Cullin-3

1

20

High-throughput

0.536

High

341769

CUL4B
Cullin-4B

1

20

High-throughput

0.536

High

341773

NUMA1
Nuclear mitotic apparatus protein 1

1

8

High-throughput

0.536

High

341776

NEDD8
Ubiquitin-like protein NEDD8

1

2

High-throughput

0.536

High

341796

CSN6
COP9 signalosome complex subunit 6

1

7

High-throughput

0.536

High

341803

CAND1
Cullin-associated NEDD8-dissociated protein 1

1

4

High-throughput

0.536

High

341827

CSN5
COP9 signalosome complex subunit 5

1

12

High-throughput

0.536

High

341828

CUL5
Cullin-5

1

20

High-throughput

0.536

High

341833

DCNL1
DCN1-like protein 1

1

2

High-throughput

0.536

High

341857

GAN
Gigaxonin

1

4

High-throughput

0.536

High

341841

SORT
Sortilin

1

0

High-throughput

0.513

High

341869

CXXC1
CXXC-type zinc finger protein 1

1

0

High-throughput

0.513

High

281848

MPPB
Mitochondrial-processing peptidase subunit beta

1

2

High-throughput

0.489

High

341768

CUL4A
Cullin-4A

1

20

High-throughput

0.489

High

341820

NUDT8
Mitochondrial coenzyme A diphosphatase NUDT8

1

1

High-throughput

0.489

High

69349

WASH1
WASH complex subunit 1

1

2

High-throughput

0.481

High

341783

AMOT
Angiomotin

1

12

High-throughput

0.481

High

341824

ANS1A
Ankyrin repeat and SAM domain-containing protein 1A

1

13

High-throughput

0.481

High

240389

PRKN
E3 ubiquitin-protein ligase parkin

1

12

High-throughput

0.479

High

341730

CFTR
Cystic fibrosis transmembrane conductance regulator

1

14

High-throughput

0.479

High

341745

IF4A3
Eukaryotic initiation factor 4A-III

1

7

High-throughput

0.479

High

341748

EPS15
Epidermal growth factor receptor substrate 15

1

9

High-throughput

0.479

High

341749

YAP1
Transcriptional coactivator YAP1

1

16

High-throughput

0.479

High

341762

TFCP2
Alpha-globin transcription factor CP2

1

4

High-throughput

0.479

High

341770

DCTN1
Dynactin subunit 1

1

13

High-throughput

0.479

High

341782

LARP7
La-related protein 7

1

9

High-throughput

0.479

High

341789

OTU1
Ubiquitin thioesterase OTU1

1

5

High-throughput

0.479

High

341855

RN208
RING finger protein 208

1

18

Small-scale

0.479

High

59900

A2BDD9
AMOT protein

1

4

High-throughput

0.470

High

341781

Q49AR9
ANKS1A protein

1

9

High-throughput

0.470

High

341813

CC197
Uncharacterized protein CCDC197

1

1

High-throughput

0.470

High

341836

MY15B
Unconventional myosin-XVB

1

4

High-throughput

0.470

High

327714

GBRAP
Gamma-aminobutyric acid receptor-associated protein

1

20

High-throughput

0.445

High

341739

BMI1
Polycomb complex protein BMI-1

1

11

High-throughput

0.445

High

341754

GBRL2
Gamma-aminobutyric acid receptor-associated protein-like 2

1

20

High-throughput

0.445

High

341852

MLP3B
Microtubule-associated protein 1 light chain 3 beta

1

20

High-throughput

0.445

High

341854

GBRL1
Gamma-aminobutyric acid receptor-associated protein-like 1

1

20

High-throughput

0.445

High

341858

MLP3A
Microtubule-associated protein 1 light chain 3 alpha

1

20

High-throughput

0.445

High

341860

LN28A
Protein lin-28 homolog A

1

2

High-throughput

0.445

High

324374

HEXI1
Protein HEXIM1

1

15

High-throughput

0.437

High

341794

PRP8
Pre-mRNA-processing-splicing factor 8

1

6

High-throughput

0.437

High

341795

MEPCE
7SK snRNA methylphosphate capping enzyme

1

9

High-throughput

0.437

High

341849

LGR4
Leucine-rich repeat-containing G-protein coupled receptor 4

1

4

High-throughput

0.437

High

341853

DDX24
ATP-dependent RNA helicase DDX24

1

14

High-throughput

0.437

High

341877

PHTF1
Protein PHTF1

1

8

High-throughput

0.437

High

341825

ESR2
Estrogen receptor beta

1

10

High-throughput

0.407

High

207395

DHX15
ATP-dependent RNA helicase DHX15

2

0

High-throughput

0.316

High

228136

CPSF5
Cleavage and polyadenylation specificity factor subunit 5

2

0

High-throughput

0.316

High

286614

STX11
Syntaxin-11

2

0

High-throughput

0.316

High

297898

SPF27
Pre-mRNA-splicing factor SPF27

2

0

High-throughput

0.316

High

341756

U2AF1
Splicing factor U2AF 35 kDa subunit

2

0

High-throughput

0.316

High

341784

CTSRT
Cation channel sperm-associated targeting subunit tau

2

0

High-throughput

0.316

High

341787

TJAP1
Tight junction-associated protein 1

2

0

High-throughput

0.316

High

341788

EFHC1
EF-hand domain-containing protein 1

2

0

High-throughput

0.316

High

341797

EPMIP
EPM2A-interacting protein 1

2

0

High-throughput

0.316

High

341808

P20D2
Xaa-Arg dipeptidase

2

0

High-throughput

0.316

High

341818

MYOZ3
Myozenin-3

2

0

High-throughput

0.316

High

341822

DYDC1
DPY30 domain-containing protein 1

2

0

High-throughput

0.316

High

341834

SMRD1
SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily D member 1

2

0

High-throughput

0.316

High

341838

TSSK3
Testis-specific serine/threonine-protein kinase 3

2

0

High-throughput

0.316

High

341843

EFC4B
EF-hand calcium-binding domain-containing protein 4B

2

0

High-throughput

0.316

High

341847

SCNM1
Sodium channel modifier 1

2

0

High-throughput

0.316

High

341859

ARMC7
Armadillo repeat-containing protein 7

2

0

High-throughput

0.316

High

341873

CS025
UPF0449 protein C19orf25

2

0

High-throughput

0.316

High

341876

OSGI1
Oxidative stress-induced growth inhibitor 1

2

0

High-throughput

0.316

High

341864

ZC4H2
Zinc finger C4H2 domain-containing protein

1

0

High-throughput

0.279

Low

341819

CEMIP
Cell migration-inducing and hyaluronan-binding protein

1

0

Small-scale

0.249

Low


Service provided by Combinatics, Japan

Last updated: 11Aug2025