Protein: PRDX3
Thioredoxin-dependent peroxide reductase, mitochondrial (EC 1.11.1.24) (Antioxidant protein 1) (AOP-1) (HBC189) (Peroxiredoxin III) (Prx-III) (Peroxiredoxin-3) (Protein MER5 homolog) (Thioredoxin-dependent peroxiredoxin 3)

Gene: PRDX3
Organism: Homo sapiens
Interactions: 222
UniProt ID: P30048

Gene Ontology (top 5):
GO:0001893 - maternal placenta development
GO:0005654 - nucleoplasm
GO:0005737 - cytoplasm
GO:0005739 - mitochondrion
GO:0005759 - mitochondrial matrix

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

670892

PRDX3
Thioredoxin-dependent peroxide reductase, mitochondrial

3

14

Small-scale

0.820

High

670896

PRDX2
Peroxiredoxin-2

1

15

High-throughput

0.691

High

670935

PRDX1
Peroxiredoxin-1

1

15

High-throughput

0.691

High

670963

LRRK2
Leucine-rich repeat serine/threonine-protein kinase 2

4

8

Small-scale

0.685

High

670947

CUL4B
Cullin-4B

3

18

Small-scale

0.674

High

231064

OPA1
Dynamin-like GTPase OPA1, mitochondrial

3

4

High-throughput

0.667

High

670943

BIRC2
Baculoviral IAP repeat-containing protein 2

3

10

High-throughput

0.667

High

671009

DHRS4
Dehydrogenase/reductase SDR family member 4

3

1

High-throughput

0.667

High

199535

M3K13
Mitogen-activated protein kinase kinase kinase 13

2

4

Small-scale

0.644

High

670941

PRDX4
Peroxiredoxin-4

1

15

High-throughput

0.621

High

670920

CDC42
Cell division control protein 42 homolog

2

7

High-throughput

0.619

High

670929

XIAP
E3 ubiquitin-protein ligase XIAP

2

10

High-throughput

0.611

High

670946

CUL3
Cullin-3

2

18

High-throughput

0.611

High

671023

GORS2
Golgi reassembly-stacking protein 2

3

1

High-throughput

0.606

High

581466

VCAM1
Vascular cell adhesion protein 1

2

3

High-throughput

0.601

High

346023

MYC
Myc proto-oncogene protein

2

9

High-throughput

0.584

High

373747

RAF1
RAF proto-oncogene serine/threonine-protein kinase

2

6

High-throughput

0.584

High

670904

MDHM
Malate dehydrogenase, mitochondrial

2

5

High-throughput

0.584

High

670905

CCNF
Cyclin-F

2

6

High-throughput

0.584

High

670960

RHG31
Rho GTPase-activating protein 31

2

5

High-throughput

0.571

High

670977

RHG24
Rho GTPase-activating protein 24

2

5

High-throughput

0.571

High

531737

PDIA4
Protein disulfide-isomerase A4

1

9

High-throughput

0.553

High

528616

CFTR
Cystic fibrosis transmembrane conductance regulator

2

4

High-throughput

0.552

High

670981

DOCK8
Dedicator of cytokinesis protein 8

2

0

High-throughput

0.547

High

670906

MAGAB
Melanoma-associated antigen 11

1

4

High-throughput

0.541

High

201232

M3K7
Mitogen-activated protein kinase kinase kinase 7

1

3

High-throughput

0.536

High

362858

FINC
Fibronectin

1

4

High-throughput

0.536

High

452639

DLDH
Dihydrolipoyl dehydrogenase, mitochondrial

1

7

High-throughput

0.536

High

517078

PCNA
Proliferating cell nuclear antigen

1

2

High-throughput

0.536

High

538477

CCNB1
G2/mitotic-specific cyclin-B1

1

2

High-throughput

0.536

High

555312

H2AX
Histone H2AX

1

4

High-throughput

0.536

High

585408

E2AK2
Interferon-induced, double-stranded RNA-activated protein kinase

1

3

High-throughput

0.536

High

601140

VDAC1
Voltage-dependent anion-selective channel protein 1

1

1

High-throughput

0.536

High

670894

SDHA
Succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial

1

1

High-throughput

0.536

High

670897

CNR2
Cannabinoid receptor 2

1

1

Small-scale

0.536

High

670903

SYUA
Alpha-synuclein

1

2

High-throughput

0.536

High

670909

NEDD4
E3 ubiquitin-protein ligase NEDD4

1

7

High-throughput

0.536

High

670913

ANX11
Annexin A11

1

1

High-throughput

0.536

High

670934

KPCZ
Protein kinase C zeta type

1

4

High-throughput

0.536

High

670944

CUL1
Cullin-1

1

18

High-throughput

0.536

High

670945

CUL2
Cullin-2

1

18

High-throughput

0.536

High

670952

PLSI
Plastin-1

1

1

High-throughput

0.536

High

670971

MARK2
Serine/threonine-protein kinase MARK2

1

2

High-throughput

0.536

High

670972

COX15
Heme A synthase COX15

1

3

High-throughput

0.536

High

670974

NLRX1
NLR family member X1

1

1

High-throughput

0.536

High

670990

CSN5
COP9 signalosome complex subunit 5

1

3

High-throughput

0.536

High

670991

CUL5
Cullin-5

1

18

High-throughput

0.536

High

670998

DCNL1
DCN1-like protein 1

1

1

High-throughput

0.536

High

671000

IMP1L
Mitochondrial inner membrane protease subunit 1

1

1

High-throughput

0.536

High

671003

SMC6
Structural maintenance of chromosomes protein 6

1

2

High-throughput

0.536

High

671005

PARK7
Parkinson disease protein 7

1

4

High-throughput

0.536

High

671006

HCD2
3-hydroxyacyl-CoA dehydrogenase type-2

1

6

High-throughput

0.536

High

671015

UBA5
Ubiquitin-like modifier-activating enzyme 5

1

1

High-throughput

0.536

High

671026

MET14
N6-adenosine-methyltransferase non-catalytic subunit

1

3

High-throughput

0.536

High

671027

PAR6A
Partitioning defective 6 homolog alpha

1

5

High-throughput

0.536

High

174365

FANCG
Fanconi anemia group G protein

1

0

Small-scale

0.529

High

671025

NEK6
Serine/threonine-protein kinase Nek6

1

8

Small-scale

0.527

High

584325

TNR1A
Tumor necrosis factor receptor superfamily member 1A

1

0

High-throughput

0.518

High

158405

IKKB
Inhibitor of nuclear factor kappa-B kinase subunit beta

1

5

Small-scale

0.515

High

256943

KDM4A
Lysine-specific demethylase 4A

1

0

High-throughput

0.513

High

670902

ODO2
Dihydrolipoyllysine-residue succinyltransferase component of 2-oxoglutarate dehydrogenase complex, mitochondrial

1

0

High-throughput

0.513

High

670927

LACTB
Serine beta-lactamase-like protein LACTB, mitochondrial

1

0

High-throughput

0.513

High

671028

RPC5
DNA-directed RNA polymerase III subunit RPC5

1

0

High-throughput

0.513

High

670918

PTEN
Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN

1

6

High-throughput

0.501

High

316802

KLF8
Krueppel-like factor 8

1

2

High-throughput

0.500

High

241272

HNRC1
Heterogeneous nuclear ribonucleoprotein C-like 1

1

1

High-throughput

0.489

High

670901

SOAT1
Sterol O-acyltransferase 1

1

1

High-throughput

0.489

High

671004

IMP2L
Mitochondrial inner membrane protease subunit 2

1

1

High-throughput

0.489

High

377120

GCR
Glucocorticoid receptor

1

16

Small-scale

0.481

High

670949

HNRPD
Heterogeneous nuclear ribonucleoprotein D0

1

1

High-throughput

0.481

High

671002

KS6C1
Ribosomal protein S6 kinase delta-1

1

2

High-throughput

0.481

High

119191

LEG9
Galectin-9

1

6

High-throughput

0.479

High

125176

WWP2
NEDD4-like E3 ubiquitin-protein ligase WWP2

1

7

High-throughput

0.479

High

148429

CTRO
Citron Rho-interacting kinase

1

4

High-throughput

0.479

High

149555

COPE
Coatomer subunit epsilon

1

2

High-throughput

0.479

High

164105

ARHGA
Rho guanine nucleotide exchange factor 10

1

5

High-throughput

0.479

High

205085

TGON2
Trans-Golgi network integral membrane protein 2

1

2

High-throughput

0.479

High

214109

SPOP
Speckle-type POZ protein

1

1

High-throughput

0.479

High

226614

PRKN
E3 ubiquitin-protein ligase parkin

1

14

High-throughput

0.479

High

255535

OBSL1
Obscurin-like protein 1

1

3

High-throughput

0.479

High

262721

CISY
Citrate synthase, mitochondrial

1

1

High-throughput

0.479

High

264847

MPPB
Mitochondrial-processing peptidase subunit beta

1

1

High-throughput

0.479

High

294418

RECQ4
ATP-dependent DNA helicase Q4

1

4

High-throughput

0.479

High

298191

UFL1
E3 UFM1-protein ligase 1

1

4

High-throughput

0.479

High

302664

ARHGF
Rho guanine nucleotide exchange factor 15

1

2

High-throughput

0.479

High

302947

HEXI1
Protein HEXIM1

1

3

High-throughput

0.479

High

312490

ARI2
E3 ubiquitin-protein ligase ARIH2

1

8

High-throughput

0.479

High

379048

MYCN
N-myc proto-oncogene protein

1

9

High-throughput

0.479

High

386165

P53
Cellular tumor antigen p53

1

3

High-throughput

0.479

High

440357

ODPA
Pyruvate dehydrogenase E1 component subunit alpha, somatic form, mitochondrial

1

3

High-throughput

0.479

High

455126

PARP1
Poly [ADP-ribose] polymerase 1

1

1

High-throughput

0.479

High

475377

UBC
Polyubiquitin-C [Cleaved into: Ubiquitin]

1

10

Small-scale

0.479

High

499555

CH60
60 kDa heat shock protein, mitochondrial

1

3

High-throughput

0.479

High

530448

ITA4
Integrin alpha-4

1

5

High-throughput

0.479

High

552021

RFA2
Replication protein A 32 kDa subunit

1

5

High-throughput

0.479

High

562518

IL7RA
Interleukin-7 receptor subunit alpha

1

2

High-throughput

0.479

High

578280

PGAM1
Phosphoglycerate mutase 1

1

2

High-throughput

0.479

High

614251

PPIB
Peptidyl-prolyl cis-trans isomerase B

1

3

High-throughput

0.479

High

625149

CDK2
Cyclin-dependent kinase 2

1

9

High-throughput

0.479

High

643246

HMGB2
High mobility group protein B2

1

9

High-throughput

0.479

High

647478

MK03
Mitogen-activated protein kinase 3

1

5

Small-scale

0.479

High

650447

RFA1
Replication protein A 70 kDa DNA-binding subunit

1

5

High-throughput

0.479

High

653489

CALR
Calreticulin

1

5

High-throughput

0.479

High

670895

1433B
14-3-3 protein beta/alpha

1

5

High-throughput

0.479

High

670899

PHB1
Prohibitin 1

1

3

High-throughput

0.479

High

670900

RFA3
Replication protein A 14 kDa subunit

1

4

High-throughput

0.479

High

670908

IF2M
Translation initiation factor IF-2, mitochondrial

1

2

High-throughput

0.479

High

670910

YAP1
Transcriptional coactivator YAP1

1

10

High-throughput

0.479

High

670911

EFTU
Elongation factor Tu, mitochondrial

1

1

High-throughput

0.479

High

670912

MCM2
DNA replication licensing factor MCM2

1

3

High-throughput

0.479

High

670914

ATX3
Ataxin-3

1

3

High-throughput

0.479

High

670915

TERA
Transitional endoplasmic reticulum ATPase

1

4

High-throughput

0.479

High

670921

UBC12
NEDD8-conjugating enzyme Ubc12

1

5

High-throughput

0.479

High

670922

SUMO2
Small ubiquitin-related modifier 2

1

2

High-throughput

0.479

High

670923

UBE2H
Ubiquitin-conjugating enzyme E2 H

1

4

High-throughput

0.479

High

670925

RL11
Large ribosomal subunit protein uL5

1

1

Small-scale

0.479

High

670928

RHOG
Rho-related GTP-binding protein RhoG

1

7

High-throughput

0.479

High

670937

MPPA
Mitochondrial-processing peptidase subunit alpha

1

1

High-throughput

0.479

High

670938

TFCP2
Alpha-globin transcription factor CP2

1

2

High-throughput

0.479

High

670939

TP4A2
Protein tyrosine phosphatase type IVA 2

1

9

High-throughput

0.479

High

670940

AIMP2
Aminoacyl tRNA synthase complex-interacting multifunctional protein 2

1

2

High-throughput

0.479

High

670942

BIRC3
Baculoviral IAP repeat-containing protein 3

1

10

High-throughput

0.479

High

670948

AUHM
Methylglutaconyl-CoA hydratase, mitochondrial

1

2

High-throughput

0.479

High

670950

ICT1
Large ribosomal subunit protein mL62

1

1

High-throughput

0.479

High

670951

RBM39
RNA-binding protein 39

1

3

High-throughput

0.479

High

670953

CUL7
Cullin-7

1

3

High-throughput

0.479

High

670954

U5S1
116 kDa U5 small nuclear ribonucleoprotein component

1

6

High-throughput

0.479

High

670955

ARHG6
Rho guanine nucleotide exchange factor 6

1

1

High-throughput

0.479

High

670957

TERF2
Telomeric repeat-binding factor 2

1

4

High-throughput

0.479

High

670961

SMU1
WD40 repeat-containing protein SMU1

1

6

High-throughput

0.479

High

670962

LARP7
La-related protein 7

1

2

High-throughput

0.479

High

670966

RUSD3
Mitochondrial mRNA pseudouridine synthase RPUSD3

1

1

High-throughput

0.479

High

670967

PRP8
Pre-mRNA-processing-splicing factor 8

1

4

High-throughput

0.479

High

670969

TRI67
Tripartite motif-containing protein 67

1

10

High-throughput

0.479

High

670970

ASXL2
Putative Polycomb group protein ASXL2

1

10

High-throughput

0.479

High

670973

ZFY16
Zinc finger FYVE domain-containing protein 16

1

4

Small-scale

0.479

High

670975

ZCH18
Zinc finger CCCH domain-containing protein 18

1

3

High-throughput

0.479

High

670976

SLX4
Structure-specific endonuclease subunit SLX4

1

4

High-throughput

0.479

High

670979

EMC1
ER membrane protein complex subunit 1

1

2

High-throughput

0.479

High

670980

NHLC2
NHL repeat-containing protein 2

1

1

High-throughput

0.479

High

670982

TNIP2
TNFAIP3-interacting protein 2

1

1

High-throughput

0.479

High

670986

BAP1
Ubiquitin carboxyl-terminal hydrolase BAP1

1

9

High-throughput

0.479

High

670992

FBXW7
F-box/WD repeat-containing protein 7

1

6

High-throughput

0.479

High

670995

CHM4C
Charged multivesicular body protein 4c

1

5

High-throughput

0.479

High

670996

RUSD4
Pseudouridylate synthase RPUSD4, mitochondrial

1

1

High-throughput

0.479

High

670997

SIR1
NAD-dependent protein deacetylase sirtuin-1

1

2

Small-scale

0.479

High

670999

DDRGK
DDRGK domain-containing protein 1

1

4

High-throughput

0.479

High

671001

EFGM
Elongation factor G, mitochondrial

1

7

High-throughput

0.479

High

671007

BAG1
BAG family molecular chaperone regulator 1

1

1

High-throughput

0.479

High

671008

RHG09
Rho GTPase-activating protein 9

1

8

High-throughput

0.479

High

671013

RHG39
Rho GTPase-activating protein 39

1

6

High-throughput

0.479

High

671019

Q9H4D1
Protein kinase

1

5

High-throughput

0.479

High

671020

PKHA4
Pleckstrin homology domain-containing family A member 4

1

6

High-throughput

0.479

High

671021

EGLN3
Prolyl hydroxylase EGLN3

1

3

High-throughput

0.479

High

671029

PIHD1
PIH1 domain-containing protein 1

1

4

High-throughput

0.479

High

671031

PD1L1
Programmed cell death 1 ligand 1

1

1

High-throughput

0.479

High

671033

RHG23
Rho GTPase-activating protein 23

1

7

High-throughput

0.479

High

671034

ZRAN1
Ubiquitin thioesterase ZRANB1

1

4

High-throughput

0.479

High

671035

DS13B
Dual specificity protein phosphatase 13B

1

3

High-throughput

0.479

High

671036

HDAC5
Histone deacetylase 5

1

8

High-throughput

0.479

High

671038

TRRAP
Transformation/transcription domain-associated protein

1

1

High-throughput

0.479

High

671039

UCHL5
Ubiquitin carboxyl-terminal hydrolase isozyme L5

1

9

Small-scale

0.479

High

670931

FANCC
Fanconi anemia group C protein

1

0

Small-scale

0.460

High

59118

VWA8
von Willebrand factor A domain-containing protein 8

1

0

High-throughput

0.458

High

122512

MEN1
Menin

1

0

High-throughput

0.458

High

299325

UBXN7
UBX domain-containing protein 7

1

0

High-throughput

0.458

High

430067

PROF1
Profilin-1

1

0

High-throughput

0.458

High

562883

STMN1
Stathmin

1

0

High-throughput

0.458

High

596463

PTMS
Parathymosin

1

0

High-throughput

0.458

High

670893

PEBP1
Phosphatidylethanolamine-binding protein 1

1

0

High-throughput

0.458

High

670907

EFTS
Elongation factor Ts, mitochondrial

1

0

High-throughput

0.458

High

670916

IF6
Eukaryotic translation initiation factor 6

1

0

High-throughput

0.458

High

670924

H4
Histone H4

1

0

High-throughput

0.458

High

670926

BASP1
Brain acid soluble protein 1

1

0

High-throughput

0.458

High

670932

PO5F1
POU domain, class 5, transcription factor 1

1

0

High-throughput

0.458

High

670936

C1QBP
Complement component 1 Q subcomponent-binding protein, mitochondrial

1

0

High-throughput

0.458

High

670956

PDK1
[Pyruvate dehydrogenase

1

0

High-throughput

0.458

High

670959

CL16A
Protein CLEC16A

1

0

High-throughput

0.458

High

670965

MRM1
rRNA methyltransferase 1, mitochondrial

1

0

High-throughput

0.458

High

670978

EMC5
ER membrane protein complex subunit 5

1

0

High-throughput

0.458

High

670984

DOT1L
Histone-lysine N-methyltransferase, H3 lysine-79 specific

1

0

High-throughput

0.458

High

670987

AN32B
Acidic leucine-rich nuclear phosphoprotein 32 family member B

1

0

High-throughput

0.458

High

670993

FAKD4
FAST kinase domain-containing protein 4

1

0

High-throughput

0.458

High

670994

MCUR1
Mitochondrial calcium uniporter regulator 1

1

0

High-throughput

0.458

High

671010

TR61B
tRNA

1

0

High-throughput

0.458

High

671012

RT26
Small ribosomal subunit protein mS26

1

0

High-throughput

0.458

High

671022

MET17
Ribosome assembly protein METTL17, mitochondrial

1

0

High-throughput

0.458

High

671030

AKIP
Small ribosomal subunit protein mS38

1

0

High-throughput

0.458

High

671032

MRES1
Mitochondrial transcription rescue factor 1

1

0

High-throughput

0.458

High

670983

MUC7
Mucin-7

1

1

Small-scale

0.457

High

671011

KLF16
Krueppel-like factor 16

1

1

High-throughput

0.457

High

128459

DNM1L
Dynamin-1-like protein

1

3

Small-scale

0.445

High

230583

KATIP
Katanin-interacting protein

1

1

High-throughput

0.445

High

305981

GBRAP
Gamma-aminobutyric acid receptor-associated protein

1

20

High-throughput

0.445

High

369052

ESR1
Estrogen receptor

1

16

High-throughput

0.445

High

377952

PRIO
Major prion protein

1

1

High-throughput

0.445

High

401481

JUN
Transcription factor Jun

1

9

High-throughput

0.445

High

496385

TAU
Microtubule-associated protein tau

1

7

High-throughput

0.445

High

547720

ATF2
Cyclic AMP-dependent transcription factor ATF-2

1

5

High-throughput

0.445

High

670898

BMI1
Polycomb complex protein BMI-1

1

7

High-throughput

0.445

High

670917

RIPK4
Receptor-interacting serine/threonine-protein kinase 4

1

5

High-throughput

0.445

High

670919

GBRL2
Gamma-aminobutyric acid receptor-associated protein-like 2

1

20

High-throughput

0.445

High

670930

2ABB
Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B beta isoform

1

2

High-throughput

0.445

High

670964

CP135
Centrosomal protein of 135 kDa

1

1

High-throughput

0.445

High

670968

TIFAB
TRAF-interacting protein with FHA domain-containing protein B

1

2

High-throughput

0.445

High

670988

ESR2
Estrogen receptor beta

1

16

High-throughput

0.445

High

671014

MLP3B
Microtubule-associated proteins 1A/1B light chain 3B

1

20

High-throughput

0.445

High

671016

GBRL1
Gamma-aminobutyric acid receptor-associated protein-like 1

1

20

High-throughput

0.445

High

671018

MLP3A
Microtubule-associated proteins 1A/1B light chain 3A

1

20

High-throughput

0.445

High

671040

SIR4
NAD-dependent protein lipoamidase sirtuin-4, mitochondrial

1

2

High-throughput

0.445

High

100521

APRIO
Alternative prion protein

1

1

High-throughput

0.437

High

329406

AGR2
Anterior gradient protein 2 homolog

1

5

High-throughput

0.437

High

654096

CALX
Calnexin

1

5

High-throughput

0.437

High

670985

STAR8
StAR-related lipid transfer protein 8

1

6

High-throughput

0.437

High

671024

WDR76
WD repeat-containing protein 76

1

9

High-throughput

0.437

High

671037

AAR2
Protein AAR2 homolog

1

4

High-throughput

0.437

High

670933

OCRL
Inositol polyphosphate 5-phosphatase OCRL

1

0

High-throughput

0.426

High

670958

ZNF77
Zinc finger protein 77

2

0

High-throughput

0.316

High

321972

ZMYM6
Zinc finger MYM-type protein 6

1

0

High-throughput

0.279

Low

671017

UN93B
Protein unc-93 homolog B1

1

0

High-throughput

0.279

Low

670989

GGH
Gamma-glutamyl hydrolase

1

0

High-throughput

0.249

Low


Service provided by Combinatics, Japan

Last updated: 15 Jul 2024