Interactor 1: P53 (P04637)
Cellular tumor antigen p53 (Antigen NY-CO-13) (Phosphoprotein p53) (Tumor suppressor p53)
Gene: TP53

Interactor 2: MDM2 (Q00987)
E3 ubiquitin-protein ligase Mdm2 (EC 2.3.2.27) (Double minute 2 protein) (Hdm2) (Oncoprotein Mdm2) (RING-type E3 ubiquitin transferase Mdm2) (p53-binding protein Mdm2)
Gene: MDM2

Species: Homo sapiens

Source: mint

Category: Small-scale

Confidence: High

Method score Annotation score Interaction score
0.99 1.00 1.000

The method score is based on:

Property Details
Experiments 19483087, 25168242, 25156994, 25283148, 25313037, 24240685, 25384516, 19303885, 23826318, 24659749, 26186194, 25362358, 25464845, 16595680, 26578655, 25417702, 25277184, 25609649, 26556313, 24621507 and 482 others

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Identification Methods affinity chromatography technology, pull down, enzymatic study, x-ray crystallography, protein complementation assay, fluorescent resonance energy transfer, unspecified method, proximity labelling technology, far western blotting, two hybrid and 19 others

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Interaction Type physical association, direct interaction, association, ubiquitination reaction

The annotation score is based on:

Property Details
Interacting Pfam domains P53_TAD~SWIB
Common GO terms GO:0000122 - negative regulation of transcription by RNA polymerase II
GO:0002039 - p53 binding
GO:0005634 - nucleus
GO:0005654 - nucleoplasm
GO:0005730 - nucleolus
and 20 others

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Homologous interactions 10

Homologous interactions

Color coding for hit scores

1 393
Hs

1 491
+ Hs
+ Mm
+ Rn
+ Hs
+ Hs
+ Hs
+ Mm
+ Mm
+ Hs
+ Hs

Service provided by Combinatics, Japan

Last updated: 15 Jul 2024