Interactor 1: P53 (P04637)
Cellular tumor antigen p53 (Antigen NY-CO-13) (Phosphoprotein p53) (Tumor suppressor p53)
Gene: TP53
Interactor 2: UBE3A (Q05086)
Ubiquitin-protein ligase E3A (EC 2.3.2.26) (E6AP ubiquitin-protein ligase) (HECT-type ubiquitin transferase E3A) (Human papillomavirus E6-associated protein) (Oncogenic protein-associated protein E6-AP) (Renal carcinoma antigen NY-REN-54)
Gene: UBE3A
Species: Homo sapiens
Source: intact
Category: Small-scale
Confidence: High
| Method score | Annotation score | Interaction score |
|---|---|---|
| 0.97 | 0.60 | 0.767 |
The method score is based on:
| Property | Details |
|---|---|
| Experiments | 1661671, 26789255, 9688277, 8380895, 17131388, 9450543, 7708685, 7724550, 29263404, 31971989, 31492752, 35025136, 35045253, 19364824, 8090726, 23040663, 15001357, 16493710, 11027293, 29426014 |
| Identification Methods | pull down, affinity chromatography technology, enzymatic study, x-ray crystallography, surface plasmon resonance, two hybrid prey pooling approach, two hybrid array |
| Interaction Type | direct interaction, physical association, association |
The annotation score is based on:
| Property | Details |
|---|---|
| Interacting Pfam domains | - |
| Common GO terms | GO:0005634 - nucleus GO:0005829 - cytosol GO:0045944 - positive regulation of transcription by RNA polymerase II |
| Homologous interactions | 17 |
Homologous interactions
Color coding for hit scores 
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Service provided by Combinatics, Japan
Last updated: 15 Jul 2024
