Protein: TOP2
DNA topoisomerase 2 (EC 5.6.2.2) (DNA topoisomerase II)

Gene: TOP2
Organism: Saccharomyces cerevisiae S288C
Interactions: 143
UniProt ID: P06786

Gene Ontology (top 5):
GO:0000019 - regulation of mitotic recombination
GO:0000712 - resolution of meiotic recombination intermediates
GO:0000795 - synaptonemal complex
GO:0000819 - sister chromatid segregation
GO:0003677 - DNA binding

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

420068

TOP2
DNA topoisomerase 2

9

16

Small-scale

0.970

High

392244

H2A2
Histone H2A.2

3

7

High-throughput

0.650

High

420098

SPT16
FACT complex subunit SPT16

3

1

High-throughput

0.650

High

420189

SMT3
Ubiquitin-like protein SMT3

3

4

High-throughput

0.645

High

420133

ATAD2
ATPase histone chaperone YTA7

3

1

Small-scale

0.640

High

420196

CMR1
DNA damage-binding protein CMR1

3

10

High-throughput

0.640

High

420117

OLA1
Obg-like ATPase 1

2

2

High-throughput

0.621

High

420187

YRA1
RNA annealing protein YRA1

2

1

High-throughput

0.621

High

420105

DRS1
ATP-dependent RNA helicase DRS1

1

2

High-throughput

0.618

High

420080

CSK22
Casein kinase II subunit alpha'

2

4

High-throughput

0.611

High

355737

H2B2
Histone H2B.2

2

11

High-throughput

0.601

High

420073

SSB1
Ribosome-associated molecular chaperone SSB1

2

5

High-throughput

0.601

High

420166

POB3
FACT complex subunit POB3

2

4

High-throughput

0.601

High

420171

YL455
PWWP domain-containing protein YLR455W

2

2

High-throughput

0.601

High

420156

MCE1
mRNA-capping enzyme subunit alpha

2

0

High-throughput

0.595

High

420163

SIZ1
E3 SUMO-protein ligase SIZ1

2

4

Small-scale

0.595

High

420119

RFC5
Replication factor C subunit 5

2

1

High-throughput

0.588

High

356167

H4
Histone H4

2

4

High-throughput

0.584

High

420155

H3
Histone H3

2

9

High-throughput

0.584

High

420197

H2AZ
Histone H2A.Z

2

8

High-throughput

0.584

High

420153

APJ1
J domain-containing protein APJ1

2

5

High-throughput

0.571

High

420085

KPC1
Protein kinase C-like 1

1

7

Small-scale

0.568

High

420071

HSP71
Heat shock protein SSA1

2

5

High-throughput

0.552

High

420199

YB111
Uncharacterized helicase-like protein YBL111C

1

0

High-throughput

0.546

High

420099

UBP4
Ubiquitin carboxyl-terminal hydrolase 4

1

5

High-throughput

0.536

High

420125

DUN1
DNA damage response protein kinase DUN1

1

1

High-throughput

0.536

High

420132

TBP6
Probable 26S proteasome subunit YTA6

1

2

High-throughput

0.536

High

420149

BRE5
UBP3-associated protein BRE5

1

3

High-throughput

0.536

High

420195

NOP56
Nucleolar protein 56

1

2

High-throughput

0.536

High

420182

ULS1
ATP-dependent helicase ULS1

1

6

Small-scale

0.527

High

420081

PYRC
Dihydroorotase

1

0

High-throughput

0.518

High

420076

CSK21
Casein kinase II subunit alpha

1

8

High-throughput

0.515

High

420192

RNH2C
Ribonuclease H2 subunit C

1

0

High-throughput

0.513

High

397562

OTC
Ornithine carbamoyltransferase

1

1

High-throughput

0.500

High

420070

SSBP1
Single-stranded nucleic acid-binding protein

1

1

High-throughput

0.500

High

420111

BMH2
Protein BMH2

1

2

High-throughput

0.500

High

420082

REB1
DNA-binding protein REB1

1

0

High-throughput

0.493

High

420124

NACA
Nascent polypeptide-associated complex subunit alpha

1

0

High-throughput

0.493

High

420129

SLX8
E3 ubiquitin-protein ligase complex SLX5-SLX8 subunit SLX8

1

0

High-throughput

0.493

High

420150

CSL4
Exosome complex component CSL4

1

0

High-throughput

0.493

High

420179

RRP44
Exosome complex exonuclease DIS3

1

0

High-throughput

0.493

High

420142

CSK2B
Casein kinase II subunit beta

1

2

High-throughput

0.489

High

420089

PAT1
Deadenylation-dependent mRNA-decapping factor PAT1

1

0

Small-scale

0.486

High

376581

PABP
Polyadenylate-binding protein, cytoplasmic and nuclear

1

0

High-throughput

0.479

High

420074

G6PI
Glucose-6-phosphate isomerase

1

0

High-throughput

0.479

High

420087

SRO9
RNA-binding protein SRO9

1

0

High-throughput

0.479

High

355300

H2B1
Histone H2B.1

1

11

High-throughput

0.479

High

406649

RS3
Small ribosomal subunit protein uS3

1

3

High-throughput

0.479

High

420077

RPB3
DNA-directed RNA polymerase II subunit RPB3

1

1

High-throughput

0.479

High

420083

RFA1
Replication factor A protein 1

1

2

Small-scale

0.479

High

420088

RSC6
Chromatin structure-remodeling complex protein RSC6

1

2

High-throughput

0.479

High

420090

SPT5
Transcription elongation factor SPT5

1

1

High-throughput

0.479

High

420091

TF2B
Transcription initiation factor IIB

1

2

High-throughput

0.479

High

420092

BMH1
Protein BMH1

1

2

High-throughput

0.479

High

420093

MCM5
Minichromosome maintenance protein 5

1

1

High-throughput

0.479

High

420095

RPC3
DNA-directed RNA polymerase III subunit RPC3

1

1

High-throughput

0.479

High

420101

STH1
Nuclear protein STH1/NPS1

1

9

High-throughput

0.479

High

420102

CHD1
Chromo domain-containing protein 1

1

8

High-throughput

0.479

High

420104

GSP1
GTP-binding nuclear protein GSP1/CNR1

1

2

High-throughput

0.479

High

420110

SAS3
Histone acetyltransferase SAS3

1

1

High-throughput

0.479

High

420112

BDF1
Bromodomain-containing factor 1

1

15

High-throughput

0.479

High

420113

CENPA
Histone H3-like centromeric protein CSE4

1

9

High-throughput

0.479

High

420115

ISW1
ISWI chromatin-remodeling complex ATPase ISW1

1

9

High-throughput

0.479

High

420121

RFC1
Replication factor C subunit 1

1

1

High-throughput

0.479

High

420122

RSC30
Chromatin structure-remodeling complex protein RSC30

1

1

High-throughput

0.479

High

420134

RFC2
Replication factor C subunit 2

1

1

High-throughput

0.479

High

420137

ULP2
Ubiquitin-like-specific protease 2

1

2

High-throughput

0.479

High

420140

RSC8
Chromatin structure-remodeling complex protein RSC8

1

1

High-throughput

0.479

High

420146

UBC9
SUMO-conjugating enzyme UBC9

1

2

High-throughput

0.479

High

420151

NOP13
Nucleolar protein 13

1

4

High-throughput

0.479

High

420152

CBK1
Serine/threonine-protein kinase CBK1

1

1

Small-scale

0.479

High

420161

HOS3
Histone deacetylase HOS3

1

5

High-throughput

0.479

High

420167

ARP9
Actin-like protein ARP9

1

1

High-throughput

0.479

High

420169

MMS22
E3 ubiquitin-protein ligase substrate receptor MMS22

1

2

High-throughput

0.479

High

420170

SFH1
Chromatin structure-remodeling complex subunit SFH1

1

1

High-throughput

0.479

High

420173

IWS1
Transcription factor SPN1

1

1

High-throughput

0.479

High

420175

RSC3
Chromatin structure-remodeling complex protein RSC3

1

1

High-throughput

0.479

High

420176

BDF2
Bromodomain-containing factor 2

1

14

High-throughput

0.479

High

420183

YTM1
Ribosome biogenesis protein YTM1

1

10

High-throughput

0.479

High

420185

YL11B
Transposon Ty1-LR1 Gag-Pol polyprotein

1

1

High-throughput

0.479

High

420188

SIZ2
E3 SUMO-protein ligase SIZ2

1

4

High-throughput

0.479

High

420190

NTO1
NuA3 HAT complex component NTO1

1

1

High-throughput

0.479

High

420193

ARP7
Actin-related protein 7

1

2

High-throughput

0.479

High

420194

EAF3
Chromatin modification-related protein EAF3

1

1

High-throughput

0.479

High

420198

SMC6
Structural maintenance of chromosomes protein 6

1

3

Small-scale

0.479

High

420075

SRS2
ATP-dependent DNA helicase SRS2

1

0

Small-scale

0.460

High

420084

APN1
Apurinic-apyrimidinic endonuclease 1

1

0

High-throughput

0.458

High

420103

RSC7
Chromatin structure-remodeling complex subunit RSC7

1

0

High-throughput

0.458

High

420106

SPT4
Transcription elongation factor SPT4

1

0

High-throughput

0.458

High

420107

CBF5
H/ACA ribonucleoprotein complex subunit CBF5

1

0

High-throughput

0.458

High

420114

EAP1
Protein EAP1

1

0

High-throughput

0.458

High

420131

RT106
Histone chaperone RTT106

1

0

High-throughput

0.458

High

420136

MAM33
Mitochondrial acidic protein MAM33

1

0

High-throughput

0.458

High

420138

DSN1
Kinetochore-associated protein DSN1

1

0

High-throughput

0.458

High

420147

NSA1
Ribosome biogenesis protein NSA1

1

0

High-throughput

0.458

High

420148

RT102
Regulator of Ty1 transposition protein 102

1

0

High-throughput

0.458

High

420154

ORC1
Origin recognition complex subunit 1

1

0

High-throughput

0.458

High

420159

XRN2
5'-3' exoribonuclease 2

1

0

High-throughput

0.458

High

420160

LGE1
Transcriptional regulatory protein LGE1

1

0

High-throughput

0.458

High

420162

RSC9
Chromatin structure-remodeling complex subunit RSC9

1

0

High-throughput

0.458

High

420164

IOC4
ISWI one complex protein 4

1

0

High-throughput

0.458

High

420165

PUF6
Pumilio homology domain family member 6

1

0

High-throughput

0.458

High

420174

URN1
Pre-mRNA-splicing factor URN1

1

0

High-throughput

0.458

High

420178

RSC58
Chromatin structure-remodeling complex protein RSC58

1

0

High-throughput

0.458

High

420181

SGO1
Shugoshin

1

0

High-throughput

0.458

High

420186

SCC1
Sister chromatid cohesion protein 1

1

0

High-throughput

0.458

High

420201

HTL1
High temperature lethal protein 1

1

0

High-throughput

0.458

High

389808

VDAC1
Mitochondrial outer membrane protein porin 1

1

1

High-throughput

0.445

High

420069

HSP77
Import motor subunit, mitochondrial

1

4

High-throughput

0.445

High

420072

HSP72
Heat shock protein SSA2

1

5

High-throughput

0.445

High

420078

BIP
Endoplasmic reticulum chaperone BiP

1

1

High-throughput

0.445

High

420086

MAS5
Mitochondrial protein import protein MAS5

1

5

High-throughput

0.445

High

420094

HS104
Heat shock protein 104

1

4

High-throughput

0.445

High

420100

HSP7F
Heat shock protein homolog SSE1

1

8

High-throughput

0.445

High

420108

HSP78
Heat shock protein 78, mitochondrial

1

4

High-throughput

0.445

High

420123

SSZ1
Ribosome-associated complex subunit SSZ1

1

2

High-throughput

0.445

High

420128

HSP7E
Heat shock protein SSC3, mitochondrial

1

4

High-throughput

0.445

High

420130

SSB2
Ribosome-associated molecular chaperone SSB2

1

5

High-throughput

0.445

High

420143

DPH4
Diphthamide biosynthesis protein 4

1

4

High-throughput

0.445

High

420168

HSP7Q
Iron-sulfur cluster biogenesis chaperone, mitochondrial

1

9

High-throughput

0.445

High

420144

RS12
Small ribosomal subunit protein eS12

1

1

High-throughput

0.437

High

420157

RSC4
Chromatin structure-remodeling complex subunit RSC4

1

13

High-throughput

0.437

High

420158

MLP1
Protein MLP1

1

6

High-throughput

0.437

High

420172

RSC2
Chromatin structure-remodeling complex subunit RSC2

1

18

High-throughput

0.437

High

420177

VAM6
Vacuolar morphogenesis protein 6

1

1

High-throughput

0.437

High

420180

BRX1
Ribosome biogenesis protein BRX1

1

1

High-throughput

0.437

High

420126

TCPB
T-complex protein 1 subunit beta

1

0

High-throughput

0.426

High

420200

TECR
Very-long-chain enoyl-CoA reductase

1

0

High-throughput

0.426

High

420120

MKAR
Very-long-chain 3-oxoacyl-CoA reductase

1

1

High-throughput

0.407

High

420127

LAA1
AP-1 accessory protein LAA1

1

1

High-throughput

0.407

High

420141

ERJ5
ER-localized J domain-containing protein 5

1

4

High-throughput

0.407

High

420145

CCH1
Calcium-channel protein CCH1

1

1

High-throughput

0.407

High

420191

HSP42
Heat shock protein 42

1

2

High-throughput

0.407

High

420096

TREA
Cytosolic neutral trehalase

1

0

High-throughput

0.279

Low

420097

CDC11
Cell division control protein 11

1

0

High-throughput

0.279

Low

420109

MFT1
THO complex subunit MFT1

1

0

High-throughput

0.279

Low

420135

COPE
Coatomer subunit epsilon

1

0

High-throughput

0.269

Low

420079

ATE1
Arginyl-tRNA--protein transferase 1

1

0

Small-scale

0.251

Low

420118

FL2D
Protein MUM2

1

0

High-throughput

0.251

Low

420116

LDB7
Chromatin structure-remodeling complex protein RSC14

1

0

High-throughput

0.249

Low

420139

IOC3
ISWI one complex protein 3

1

0

High-throughput

0.249

Low

420184

IOC2
ISWI one complex protein 2

1

0

High-throughput

0.249

Low


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Last updated: 15 Jul 2024