HitPredict

Interactor 1: P53 (P04637)
Cellular tumor antigen p53 (Antigen NY-CO-13) (Phosphoprotein p53) (Tumor suppressor p53)
Gene: TP53

Interactor 2: BAK (Q16611)
Bcl-2 homologous antagonist/killer (Apoptosis regulator BAK) (Bcl-2-like protein 7) (Bcl2-L-7)
Gene: BAK1

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score Annotation score Interaction score
0.79 1.00 0.893

The method score is based on:

Property Details
Experiments 25408501, 27818144, 15077116, 32064756
Identification Methods affinity chromatography technology, pull down
Interaction Type physical association, direct interaction

The annotation score is based on:

Property Details
Interacting Pfam domains Bcl-2~P53
Common GO terms GO:0001836 - release of cytochrome c from mitochondria
GO:0005739 - mitochondrion
GO:0005783 - endoplasmic reticulum
GO:0005829 - cytosol
GO:0008285 - negative regulation of cell population proliferation
and 10 others

more...
Homologous interactions 9

Homologous interactions

Color coding for hit scores

1 393
Hs

1 211
+ Hs
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+ Mm
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+ Rn

Service provided by Combinatics, Japan

Last updated: 15 Jul 2024