HitPredict

Interactor 1: P53 (P04637)
Cellular tumor antigen p53 (Antigen NY-CO-13) (Phosphoprotein p53) (Tumor suppressor p53)
Gene: TP53

Interactor 2: PAXI1 (Q6ZW49)
PAX-interacting protein 1 (PAX transactivation activation domain-interacting protein)
Gene: PAXIP1

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.58	0.60	0.594

Property	Details
Experiments	32807901, 19433796
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0016363 - nuclear matrix GO:0030330 - DNA damage response, signal transduction by p53 class mediator GO:1902749 - regulation of cell cycle G2/M phase transition
Homologous interactions	10

Homologous interactions

Color coding for hit scores

	1 393 Hs			1 1069
+	Hs
		386733 P53_HUMAN (1-393): 0: 619: 100.00		MDC1_HUMAN (187-1069): 1.3e-57: 220: 14.77
+	Hs
		387531 P53_HUMAN (1-393): 0: 619: 100.00		ECT2_HUMAN (26-280): 1.93e-51: 198: 13.97
+	Hs
		387646 P53_HUMAN (1-393): 0: 619: 100.00		CHD7_HUMAN (188-893): 7.26e-34: 144: 9.07
+	Hs
		387207 P53_HUMAN (1-393): 0: 619: 100.00		TOPB1_HUMAN (3-336): 2.54e-18: 93.2: 16.86
+	Hs
		387139 P53_HUMAN (1-393): 0: 619: 100.00		KMT2C_HUMAN (162-612): 3.03e-12: 73.5: 9.11
+	Hs
		386371 P53_HUMAN (1-393): 0: 619: 100.00		SC24C_HUMAN (182-460): 3.09e-12: 73.2: 8.84
+	Hs
		175898 P73_HUMAN (13-362): 2.35e-166: 481: 39.74		TOPB1_HUMAN (3-336): 2.54e-18: 93.2: 16.86
+	Hs
		1266882 P63_HUMAN (28-363): 2.35e-145: 429: 42.11		TOPB1_HUMAN (3-336): 2.54e-18: 93.2: 16.86
+	Hs
		867127 P63_HUMAN (28-363): 2.35e-145: 429: 42.11		SC24C_HUMAN (182-460): 3.09e-12: 73.2: 8.84
+	Dm
		58920 Q9N6D8_DROME (124-325): 3.11e-77: 245: 24.31		A2VEF9_DROME (777-1062): 2.85e-39: 160: 17.39