HitPredict

Interactor 1: P53 (P04637)
Cellular tumor antigen p53 (Antigen NY-CO-13) (Phosphoprotein p53) (Tumor suppressor p53)
Gene: TP53

Interactor 2: KMT2C (Q8NEZ4)
Histone-lysine N-methyltransferase 2C (Lysine N-methyltransferase 2C) (EC 2.1.1.364) (Homologous to ALR protein) (Myeloid/lymphoid or mixed-lineage leukemia protein 3)
Gene: KMT2C

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.41	0.60	0.500

Property	Details
Experiments	19433796
Identification Methods	anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0003677 - DNA binding GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0005829 - cytosol GO:0045944 - positive regulation of transcription by RNA polymerase II
Homologous interactions	8

Homologous interactions

Color coding for hit scores

	1 393 Hs			1 4911
+	Hs
		386546 P53_HUMAN (1-393): 0: 619: 100.00		ANK2_HUMAN (2103-4261): 3.06e-90: 334: 11.09
+	Hs
		331693 P53_HUMAN (1-393): 0: 619: 100.00		NSD2_HUMAN (31-633): 2.18e-72: 272: 13.39
+	Hs
		165612 P53_HUMAN (1-393): 0: 619: 100.00		SET1A_HUMAN (4638-4911): 3.38e-54: 214: 29.73
+	Hs
		386746 P53_HUMAN (1-393): 0: 619: 100.00		CHD4_HUMAN (83-436): 3.08e-38: 161: 13.56
+	Hs
		386570 P53_HUMAN (1-393): 0: 619: 100.00		KMT2A_HUMAN (159-332): 7.57e-32: 140: 22.16
+	Hs
		386627 P53_HUMAN (1-393): 0: 619: 100.00		CHD3_HUMAN (390-526): 1.86e-31: 139: 21.38
+	Hs
		387750 P53_HUMAN (1-393): 0: 619: 100.00		SET1B_HUMAN (4778-4911): 3.56e-24: 115: 51.11
+	Hs
		175863 P73_HUMAN (13-362): 2.35e-166: 481: 39.74		CHD3_HUMAN (390-526): 1.86e-31: 139: 21.38