HitPredict

Interactor 1: P53 (P04637)
Cellular tumor antigen p53 (Antigen NY-CO-13) (Phosphoprotein p53) (Tumor suppressor p53)
Gene: TP53

Interactor 2: CBP (Q92793)
CREB-binding protein (Histone lysine acetyltransferase CREBBP) (EC 2.3.1.48) (Protein lactyltransferas CREBBP) (EC 2.3.1.-) (Protein-lysine acetyltransferase CREBBP) (EC 2.3.1.-)
Gene: CREBBP

Species: Homo sapiens

Source: mint

Category: Small-scale

Confidence: High

Method score Annotation score Interaction score
0.98 1.00 0.994

The method score is based on:

Property Details
Experiments 19880525, 17434128, 14759370, 12154097, 25451029, 18753379, 23908595, 27618436, 28630323, 10473588, 12426395, 11782467, 10848610, 18485870, 37219487, 19805293, 16537920, 9288775, 9194564, 14722092 and 12 others

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Identification Methods pull down, affinity chromatography technology, enzymatic study, x-ray crystallography, unspecified method, proximity labelling technology, fluorescent resonance energy transfer, anti bait coimmunoprecipitation, anti tag coimmunoprecipitation, nuclear magnetic resonance and 3 others

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Interaction Type direct interaction, physical association, association, acetylation reaction

The annotation score is based on:

Property Details
Interacting Pfam domains Creb_binding~P53_TAD, P53_TAD~zf-TAZ, Creb_binding~TAD2, TAD2~zf-TAZ
Common GO terms GO:0000122 - negative regulation of transcription by RNA polymerase II
GO:0000785 - chromatin
GO:0002039 - p53 binding
GO:0003682 - chromatin binding
GO:0005634 - nucleus
and 11 others

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Homologous interactions 17

Homologous interactions

Color coding for hit scores

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Service provided by Combinatics, Japan

Last updated: 15 Jul 2024