HitPredict

Interactor 1: P53 (P04637)
Cellular tumor antigen p53 (Antigen NY-CO-13) (Phosphoprotein p53) (Tumor suppressor p53)
Gene: TP53

Interactor 2: FBXW7 (Q969H0)
F-box/WD repeat-containing protein 7 (Archipelago homolog) (hAgo) (F-box and WD-40 domain-containing protein 7) (F-box protein FBX30) (SEL-10) (hCdc4)
Gene: FBXW7

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.87	0.60	0.725

The method score is based on:

Property	Details
Experiments	31940492, 28514442, 31346036, 33961781, 36395886
Identification Methods	affinity chromatography technology, pull down, enzymatic study, anti tag coimmunoprecipitation
Interaction Type	physical association, direct interaction, association

The annotation score is based on:

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0005730 - nucleolus GO:0005737 - cytoplasm GO:0005739 - mitochondrion and 7 others more... GO:0005783 - endoplasmic reticulum GO:0005829 - cytosol GO:0006974 - DNA damage response GO:0031625 - ubiquitin protein ligase binding GO:0032991 - protein-containing complex GO:0034644 - cellular response to UV GO:0050821 - protein stabilization
Homologous interactions	6

Homologous interactions

Color coding for hit scores

	1	393
Hs

1	707

Service provided by Combinatics, Japan

Last updated: 15 Jul 2024