Protein: APOE
Apolipoprotein E (Apo-E)

Gene: APOE
Organism: Homo sapiens
Interactions: 157
UniProt ID: P02649

Gene Ontology (top 5):
GO:0000302 - response to reactive oxygen species
GO:0001540 - amyloid-beta binding
GO:0001937 - negative regulation of endothelial cell proliferation
GO:0002021 - response to dietary excess
GO:0005102 - signaling receptor binding

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

387347

APOE
Apolipoprotein E

3

3

Small-scale

0.843

High

387355

A4
Amyloid-beta precursor protein

6

8

Small-scale

0.723

High

387367

TAU
Microtubule-associated protein tau

5

2

Small-scale

0.714

High

387387

SYUA
Alpha-synuclein

3

1

Small-scale

0.691

High

387414

LRP1
Prolow-density lipoprotein receptor-related protein 1

3

7

Small-scale

0.684

High

387419

LRP8
Low-density lipoprotein receptor-related protein 8

3

7

Small-scale

0.674

High

376456

LDLR
Low-density lipoprotein receptor

3

7

Small-scale

0.671

High

387359

MMP3
Stromelysin-1

3

2

High-throughput

0.667

High

387416

MMRN1
Multimerin-1

3

3

High-throughput

0.667

High

387458

ACE2
Angiotensin-converting enzyme 2

3

0

Small-scale

0.659

High

387374

VDAC1
Non-selective voltage-gated ion channel VDAC1

3

1

High-throughput

0.657

High

369569

A2MG
Alpha-2-macroglobulin

2

1

Small-scale

0.640

High

387373

DPA1
HLA class II histocompatibility antigen, DP alpha 1 chain

3

0

High-throughput

0.638

High

387362

MMP10
Stromelysin-2

2

2

High-throughput

0.628

High

387480

VDAC3
Non-selective voltage-gated ion channel VDAC3

2

1

High-throughput

0.628

High

387350

CO9
Complement component C9 [Cleaved into: Complement component C9a; Complement component C9b]

2

9

High-throughput

0.621

High

387464

MANS1
MANSC domain-containing protein 1

2

0

High-throughput

0.602

High

387395

CD81
CD81 antigen

2

1

Small-scale

0.601

High

387446

SORL
Sortilin-related receptor

2

7

Small-scale

0.595

High

366137

HPT
Haptoglobin

1

1

Small-scale

0.589

High

387423

CDC37
Hsp90 co-chaperone Cdc37

1

0

High-throughput

0.565

High

387426

PDCD4
Programmed cell death protein 4

1

0

High-throughput

0.565

High

387454

ECSIT
Evolutionarily conserved signaling intermediate in Toll pathway, mitochondrial

1

0

High-throughput

0.565

High

387360

CFAH
Complement factor H

1

0

Small-scale

0.564

High

387385

RL4
Large ribosomal subunit protein uL4

2

0

High-throughput

0.561

High

387403

ACTG
Actin, cytoplasmic 2

2

0

High-throughput

0.561

High

387390

F10A1
Hsc70-interacting protein

1

0

High-throughput

0.557

High

270080

TMCC2
Transmembrane and coiled-coil domains protein 2

1

0

Small-scale

0.549

High

166735

IFIT3
Interferon-induced protein with tetratricopeptide repeats 3

1

1

High-throughput

0.541

High

387366

CP2C8
Cytochrome P450 2C8

1

1

High-throughput

0.541

High

387483

MAST1
Microtubule-associated serine/threonine-protein kinase 1

1

3

High-throughput

0.541

High

210654

KLK10
Kallikrein-10

1

2

High-throughput

0.536

High

387349

APOC2
Apolipoprotein C-II

1

1

High-throughput

0.536

High

387351

ALBU
Albumin

1

2

High-throughput

0.536

High

387379

CEAM8
Cell adhesion molecule CEACAM8

1

1

High-throughput

0.536

High

387486

NPTN
Neuroplastin

1

1

High-throughput

0.536

High

387354

S100B
Protein S100-B

1

0

High-throughput

0.518

High

387389

PSN1
Presenilin-1

1

0

High-throughput

0.518

High

387449

LOXL4
Lysyl oxidase homolog 4

1

0

High-throughput

0.518

High

387476

CLCF1
Cardiotrophin-like cytokine factor 1

1

1

Small-scale

0.515

High

387363

LEG1
Galectin-1

1

3

High-throughput

0.515

High

387368

MTAP2
Microtubule-associated protein 2

1

2

High-throughput

0.515

High

387371

ZNF24
Zinc finger protein 24

1

2

High-throughput

0.515

High

387391

RBM5
RNA-binding protein 5

1

1

High-throughput

0.515

High

387413

APLP2
Amyloid beta precursor like protein 2

1

5

High-throughput

0.515

High

387418

BACD2
BTB/POZ domain-containing adapter for CUL3-mediated RhoA degradation protein 2

1

1

High-throughput

0.515

High

387425

FX4L6
Forkhead box protein D4-like 6

1

1

High-throughput

0.515

High

387437

Q8IUW6
CLSTN3 protein

1

1

High-throughput

0.515

High

387438

Q8IY40
GRIK2 protein

1

1

High-throughput

0.515

High

387444

SCRB1
Scavenger receptor class B member 1

1

1

High-throughput

0.515

High

387487

EMIL1
EMILIN-1

1

4

High-throughput

0.515

High

387381

IFNA8
Interferon alpha-8

1

0

High-throughput

0.513

High

387424

MICB
MHC class I polypeptide-related sequence B

1

0

High-throughput

0.513

High

387450

FIMP
Fertilization-influencing membrane protein

1

0

High-throughput

0.513

High

387457

TMM59
Transmembrane protein 59

1

0

High-throughput

0.513

High

387461

CSTL1
Cystatin-like 1

1

0

High-throughput

0.513

High

387377

NOS3
Nitric oxide synthase 3

1

0

High-throughput

0.504

High

387353

LCAT
Phosphatidylcholine-sterol acyltransferase

1

2

Small-scale

0.501

High

387358

HS90A
Heat shock protein HSP 90-alpha

1

1

Small-scale

0.501

High

387378

AKT1
RAC-alpha serine/threonine-protein kinase

1

2

Small-scale

0.501

High

387407

VLDLR
Very low-density lipoprotein receptor

1

7

Small-scale

0.501

High

387408

LRP2
Low-density lipoprotein receptor-related protein 2

1

7

Small-scale

0.501

High

387474

TREM2
Triggering receptor expressed on myeloid cells 2

1

1

Small-scale

0.501

High

280894

HYPM
Huntingtin-interacting protein M

1

0

High-throughput

0.493

High

387352

MT2
Metallothionein-2

1

0

High-throughput

0.493

High

387376

CNTF
Ciliary neurotrophic factor

1

0

High-throughput

0.493

High

387433

RN111
E3 ubiquitin-protein ligase Arkadia

1

0

High-throughput

0.493

High

387436

SPA2L
Spermatogenesis-associated protein 2-like protein

1

0

High-throughput

0.493

High

387443

UBA3
NEDD8-activating enzyme E1 catalytic subunit

1

0

High-throughput

0.493

High

387459

LDH6B
L-lactate dehydrogenase A-like 6B

1

0

High-throughput

0.493

High

387462

CSTP1
Centriolar satellite-associated tubulin polyglutamylase complex regulator 1

1

0

High-throughput

0.493

High

387463

DCR1B
5' exonuclease Apollo

1

0

High-throughput

0.493

High

387465

VPP4
V-type proton ATPase 116 kDa subunit a 4

1

0

High-throughput

0.493

High

387469

RASF1
Ras association domain-containing protein 1

1

0

High-throughput

0.493

High

387471

CT141
Uncharacterized protein C20orf141

1

0

High-throughput

0.493

High

387479

KAD3
GTP:AMP phosphotransferase AK3, mitochondrial

1

0

High-throughput

0.493

High

387484

MSRB2
Methionine-R-sulfoxide reductase B2, mitochondrial

1

0

High-throughput

0.493

High

387440

CA2D3
Voltage-dependent calcium channel subunit alpha-2/delta-3

1

2

High-throughput

0.489

High

329412

EPN2
Epsin-2

1

1

High-throughput

0.481

High

387375

PIMT
Protein-L-isoaspartate(D-aspartate) O-methyltransferase

1

1

High-throughput

0.481

High

387382

CP2CI
Cytochrome P450 2C18

1

1

High-throughput

0.481

High

387386

LONM
Lon protease homolog, mitochondrial

1

1

High-throughput

0.481

High

387393

FOXG1
Forkhead box protein G1

1

3

High-throughput

0.481

High

387412

TYRO3
Tyrosine-protein kinase receptor TYRO3

1

5

High-throughput

0.481

High

387417

IFIT5
Interferon-induced protein with tetratricopeptide repeats 5

1

1

High-throughput

0.481

High

387452

ZN558
Zinc finger protein 558

1

1

High-throughput

0.481

High

387453

PRAM
PML-RARA-regulated adapter molecule 1

1

1

High-throughput

0.481

High

387405

CSK21
Casein kinase II subunit alpha

1

0

Small-scale

0.480

High

125129

LEG9
Galectin-9

1

3

Small-scale

0.479

High

277235

PITX3
Pituitary homeobox 3

1

1

Small-scale

0.479

High

387348

APOA2
Apolipoprotein A-II

1

1

High-throughput

0.479

High

387356

TPM3
Tropomyosin alpha-3 chain

1

1

High-throughput

0.479

High

387364

TPM1
Tropomyosin alpha-1 chain

1

1

High-throughput

0.479

High

387365

SAA1
Serum amyloid A-1 protein

1

3

High-throughput

0.479

High

387370

ITAM
Integrin alpha-M

1

1

Small-scale

0.479

High

387384

ACHA7
Neuronal acetylcholine receptor subunit alpha-7

1

1

Small-scale

0.479

High

387392

PLTP
Phospholipid transfer protein

1

2

Small-scale

0.479

High

387415

FOXO1
Forkhead box protein O1

1

2

High-throughput

0.479

High

387434

TRI67
Tripartite motif-containing protein 67

1

1

High-throughput

0.479

High

387439

PHAR4
Phosphatase and actin regulator 4

1

1

High-throughput

0.479

High

387455

CSTN3
Calsyntenin-3

1

1

Small-scale

0.479

High

387475

RRBP1
Ribosome-binding protein 1

1

2

High-throughput

0.479

High

387380

PRDX2
Peroxiredoxin-2

1

0

High-throughput

0.460

High

387394

FXYD7
FXYD domain-containing ion transport regulator 7

1

0

High-throughput

0.460

High

387421

RHEB
GTP-binding protein Rheb

1

0

High-throughput

0.460

High

387422

ELAV1
ELAV-like protein 1

1

0

High-throughput

0.460

High

387430

IQEC1
IQ motif and SEC7 domain-containing protein 1

1

0

High-throughput

0.460

High

387447

HTRA1
Serine protease HTRA1

1

0

High-throughput

0.460

High

387467

ANKH
Mineralization regulator ANKH

1

0

High-throughput

0.460

High

387468

M1IP1
Mid1-interacting protein 1

1

0

High-throughput

0.460

High

387481

SYFA
Phenylalanine--tRNA ligase alpha subunit

1

0

High-throughput

0.460

High

136765

AGRIN
Agrin [Cleaved into: Agrin N-terminal 110 kDa subunit; Agrin C-terminal 110 kDa subunit; Agrin C-terminal 90 kDa fragment

1

0

High-throughput

0.458

High

387369

HSP7C
Heat shock cognate 71 kDa protein

1

0

High-throughput

0.458

High

387383

CTNB1
Catenin beta-1

1

0

High-throughput

0.458

High

387388

YAP1
Transcriptional coactivator YAP1

1

0

High-throughput

0.458

High

387396

WDR5
WD repeat-containing protein 5

1

0

High-throughput

0.458

High

387397

RS7
Small ribosomal subunit protein eS7

1

0

High-throughput

0.458

High

387398

RS14
Small ribosomal subunit protein uS11

1

0

High-throughput

0.458

High

387399

RS26
Small ribosomal subunit protein eS26

1

0

High-throughput

0.458

High

387400

RS28
Small ribosomal subunit protein eS28

1

0

High-throughput

0.458

High

387401

RL8
Large ribosomal subunit protein uL2

1

0

High-throughput

0.458

High

387402

1433Z
14-3-3 protein zeta/delta

1

0

High-throughput

0.458

High

387409

CLH1
Clathrin heavy chain 1

1

0

High-throughput

0.458

High

387410

RL6
Large ribosomal subunit protein eL6

1

0

High-throughput

0.458

High

387420

PCBP1
Poly(rC)-binding protein 1

1

0

High-throughput

0.458

High

387428

OTU1
Ubiquitin thioesterase OTU1

1

0

High-throughput

0.458

High

387442

FBX22
F-box only protein 22

1

0

High-throughput

0.458

High

387466

SENP2
Sentrin-specific protease 2

1

0

Small-scale

0.458

High

387478

ZRAN1
Ubiquitin thioesterase ZRANB1

1

0

High-throughput

0.458

High

387357

NFM
Neurofilament medium polypeptide

1

4

Small-scale

0.457

High

297391

PIAS1
E3 SUMO-protein ligase PIAS1

1

2

High-throughput

0.457

High

297729

PIAS2
E3 SUMO-protein ligase PIAS2

1

2

High-throughput

0.457

High

387435

HIPK1
Homeodomain-interacting protein kinase 1

1

2

High-throughput

0.457

High

387488

PIAS3
E3 SUMO-protein ligase PIAS3

1

2

High-throughput

0.457

High

387372

VCAM1
Vascular cell adhesion protein 1

1

2

High-throughput

0.445

High

387431

PKHA7
Pleckstrin homology domain-containing family A member 7

1

1

High-throughput

0.445

High

387451

MF14A
Hippocampus abundant transcript 1 protein

1

1

High-throughput

0.445

High

387482

PKHA6
Pleckstrin homology domain-containing family A member 6

1

1

High-throughput

0.439

High

387361

RU17
U1 small nuclear ribonucleoprotein 70 kDa

1

0

High-throughput

0.438

High

387404

UBC9
SUMO-conjugating enzyme UBC9

1

0

High-throughput

0.438

High

387429

PLAG1
Zinc finger protein PLAG1

1

0

High-throughput

0.438

High

387470

TOPRS
E3 ubiquitin-protein ligase Topors

1

0

High-throughput

0.438

High

387485

ZN451
E3 SUMO-protein ligase ZNF451

1

0

High-throughput

0.438

High

360702

COX3
Cytochrome c oxidase subunit 3

1

1

Small-scale

0.437

High

387406

S35B1
Solute carrier family 35 member B1

1

0

High-throughput

0.426

High

387411

VMAT2
Synaptic vesicular amine transporter

1

0

High-throughput

0.426

High

387427

NTCP5
Sodium/bile acid cotransporter 5

1

0

High-throughput

0.426

High

387445

SL9A6
Sodium/hydrogen exchanger 6

1

0

High-throughput

0.426

High

387477

S23A2
Solute carrier family 23 member 2

1

0

High-throughput

0.426

High

387448

GCDH
Glutaryl-CoA dehydrogenase, mitochondrial

1

0

High-throughput

0.282

High

387460

RNF32
RING finger protein 32

1

0

High-throughput

0.282

High

387432

TTC33
Tetratricopeptide repeat protein 33

1

0

High-throughput

0.268

Low

387473

UTP6
U3 small nucleolar RNA-associated protein 6 homolog

1

0

High-throughput

0.268

Low

387441

ARFG1
ADP-ribosylation factor GTPase-activating protein 1

1

0

High-throughput

0.251

Low

387456

TIM29
Mitochondrial import inner membrane translocase subunit Tim29

1

0

High-throughput

0.251

Low

387472

FXL12
F-box/LRR-repeat protein 12

1

0

High-throughput

0.251

Low


Service provided by Combinatics, Japan

Last updated: 11Aug2025