Interactor 1: P53 (P04637)
Cellular tumor antigen p53 (Antigen NY-CO-13) (Phosphoprotein p53) (Tumor suppressor p53)
Gene: TP53
Interactor 2: SIR1 (Q96EB6)
NAD-dependent protein deacetylase sirtuin-1 (hSIRT1) (EC 2.3.1.286) (NAD-dependent protein deacylase sirtuin-1) (EC 2.3.1.-) (Regulatory protein SIR2 homolog 1) (SIR2-like protein 1) (hSIR2) [Cleaved into: SirtT1 75 kDa fragment (75SirT1)]
Gene: SIRT1
Species: Homo sapiens
Source: intact
Category: Small-scale
Confidence: High
| Method score | Annotation score | Interaction score |
|---|---|---|
| 0.97 | 0.60 | 0.766 |
The method score is based on:
| Property | Details |
|---|---|
| Experiments | 22689577, 18753379, 35931247, 38580884, 21149449, 22389628, 12006491, 17964266, 22735644, 34163012, 18235502, 21245319, 18235501, 11672523, 15205477 |
| Identification Methods | affinity chromatography technology, proximity labelling technology, pull down, enzymatic study, anti tag coimmunoprecipitation, anti bait coimmunoprecipitation, deacetylase assay, acetylase assay |
| Interaction Type | physical association, direct interaction, association, deacetylation reaction |
The annotation score is based on:
| Property | Details |
|---|---|
| Interacting Pfam domains | - |
| Common GO terms | GO:0000122 - negative regulation of transcription by RNA polymerase II GO:0000785 - chromatin GO:0000978 - RNA polymerase II cis-regulatory region sequence-specific DNA binding GO:0002039 - p53 binding GO:0005634 - nucleus and 22 others more... |
| Homologous interactions | 5 |
Homologous interactions
Color coding for hit scores 
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Service provided by Combinatics, Japan
Last updated: 15 Jul 2024
