Protein: UBE2U
Ubiquitin-conjugating enzyme E2 U (EC 2.3.2.23) (E2 ubiquitin-conjugating enzyme U) (Ubiquitin carrier protein U) (Ubiquitin-protein ligase U)

Gene: UBE2U
Organism: Homo sapiens
Interactions: 145
UniProt ID: Q5VVX9

Gene Ontology (top 5):
GO:0000209 - protein polyubiquitination
GO:0005524 - ATP binding
GO:0006281 - DNA repair
GO:0033503 - HULC complex
GO:0043161 - proteasome-mediated ubiquitin-dependent protein catabolic process

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

1093365

TRI32
E3 ubiquitin-protein ligase TRIM32

2

20

High-throughput

0.834

High

1218722

R144B
E3 ubiquitin-protein ligase RNF144B

2

20

High-throughput

0.729

High

194232

R113A
E3 ubiquitin-protein ligase RNF113A

1

2

High-throughput

0.698

High

279050

TRIM3
Tripartite motif-containing protein 3

1

20

High-throughput

0.698

High

714186

PML
Protein PML

1

20

High-throughput

0.698

High

1028239

MDM2
E3 ubiquitin-protein ligase Mdm2

1

14

High-throughput

0.698

High

1218724

SYVN1
E3 ubiquitin-protein ligase synoviolin

1

20

High-throughput

0.698

High

1218728

DZIP3
E3 ubiquitin-protein ligase DZIP3

1

20

High-throughput

0.698

High

1218732

ZSWM2
E3 ubiquitin-protein ligase ZSWIM2

1

20

High-throughput

0.698

High

1218734

RN139
E3 ubiquitin-protein ligase RNF139

1

20

High-throughput

0.698

High

1218738

MUL1
Mitochondrial ubiquitin ligase activator of NFKB 1

1

20

High-throughput

0.698

High

1218739

RN166
E3 ubiquitin-protein ligase RNF166

1

20

High-throughput

0.698

High

1218742

RN125
E3 ubiquitin-protein ligase RNF125

1

20

High-throughput

0.698

High

1218744

RN170
E3 ubiquitin-protein ligase RNF170

1

2

High-throughput

0.698

High

1218757

HOIL1
RanBP-type and C3HC4-type zinc finger-containing protein 1

1

20

High-throughput

0.698

High

1218761

TRIM2
Tripartite motif-containing protein 2

1

20

High-throughput

0.698

High

1218763

RNF41
E3 ubiquitin-protein ligase NRDP1

1

20

High-throughput

0.698

High

1218773

RN114
E3 ubiquitin-protein ligase RNF114

1

20

High-throughput

0.698

High

647574

UBA1
Ubiquitin-like modifier-activating enzyme 1

1

20

Small-scale

0.647

High

766097

PCGF2
Polycomb group RING finger protein 2

1

20

High-throughput

0.625

High

783293

TRI23
E3 ubiquitin-protein ligase TRIM23

1

8

High-throughput

0.625

High

1208106

RNFT1
E3 ubiquitin-protein ligase RNFT1

1

20

High-throughput

0.625

High

1218721

TRI65
E3 ubiquitin-protein ligase TRIM65

1

20

High-throughput

0.625

High

1218723

TRI46
Tripartite motif-containing protein 46

1

20

High-throughput

0.625

High

1218725

TRI74
Tripartite motif-containing protein 74

1

20

High-throughput

0.625

High

1218729

MIB1
E3 ubiquitin-protein ligase MIB1

1

8

High-throughput

0.625

High

1218731

RNF10
E3 ubiquitin-protein ligase RNF10

1

20

High-throughput

0.625

High

1218733

PJA1
E3 ubiquitin-protein ligase Praja-1

1

20

High-throughput

0.625

High

1218740

MIB2
E3 ubiquitin-protein ligase MIB2

1

8

High-throughput

0.625

High

1218741

RNF25
E3 ubiquitin-protein ligase RNF25

1

15

High-throughput

0.625

High

1218745

TRI47
E3 ubiquitin-protein ligase TRIM47

1

20

High-throughput

0.625

High

1218746

RING2
E3 ubiquitin-protein ligase RING2

1

20

High-throughput

0.625

High

1218750

RNF5
E3 ubiquitin-protein ligase RNF5

1

20

High-throughput

0.625

High

1218751

PCGF1
Polycomb group RING finger protein 1

1

20

High-throughput

0.625

High

1218752

TRAIP
E3 ubiquitin-protein ligase TRAIP

1

7

High-throughput

0.625

High

1218754

RNF26
E3 ubiquitin-protein ligase RNF26

1

20

High-throughput

0.625

High

1218755

PCGF6
Polycomb group RING finger protein 6

1

20

High-throughput

0.625

High

1218758

TRI54
Tripartite motif-containing protein 54

1

20

High-throughput

0.625

High

1218759

TRI15
E3 ubiquitin-protein ligase TRIM15

1

20

High-throughput

0.625

High

1218760

TRIM5
Tripartite motif-containing protein 5

1

20

High-throughput

0.625

High

1218762

VPS11
Vacuolar protein sorting-associated protein 11 homolog

1

5

High-throughput

0.625

High

1218764

APC11
Anaphase-promoting complex subunit 11

1

20

High-throughput

0.625

High

1218766

RN181
E3 ubiquitin-protein ligase RNF181

1

20

High-throughput

0.625

High

1218767

RNF14
E3 ubiquitin-protein ligase RNF14

1

20

High-throughput

0.625

High

1218770

RN150
RING finger protein 150

1

20

High-throughput

0.625

High

1218771

TRI35
E3 ubiquitin-protein ligase TRIM35

1

20

High-throughput

0.625

High

1218772

RNF11
RING finger protein 11

1

20

High-throughput

0.625

High

651358

CBL
E3 ubiquitin-protein ligase CBL

1

13

Small-scale

0.621

High

1093635

MKRN3
E3 ubiquitin-protein ligase makorin-3

1

14

High-throughput

0.621

High

1218717

RN213
E3 ubiquitin-protein ligase RNF213

1

2

Small-scale

0.621

High

1218747

CGRF1
Cell growth regulator with RING finger domain protein 1

1

0

High-throughput

0.584

High

1218730

R113B
RING finger protein 113B

1

2

High-throughput

0.555

High

1218737

TRI63
E3 ubiquitin-protein ligase TRIM63

1

20

High-throughput

0.555

High

1218768

TRIM1
Probable E3 ubiquitin-protein ligase MID2

1

20

High-throughput

0.555

High

142685

TRI38
E3 ubiquitin-protein ligase TRIM38

1

20

High-throughput

0.541

High

1099997

TIF1B
Transcription intermediary factor 1-beta

1

20

High-throughput

0.541

High

1218748

BARD1
BRCA1-associated RING domain protein 1

1

9

High-throughput

0.541

High

1218765

BFAR
Bifunctional apoptosis regulator

1

20

High-throughput

0.541

High

1207470

Q5JVY0
Tripartite motif containing 32

1

20

High-throughput

0.528

High

1218719

Q6GX22
E3 ubiquitin-protein ligase Midline-1

1

20

High-throughput

0.528

High

1218720

Q6NR77
Ring finger protein 28

1

20

High-throughput

0.528

High

822705

VHL
von Hippel-Lindau disease tumor suppressor

1

3

High-throughput

0.515

High

180840

TIF1A
Transcription intermediary factor 1-alpha

1

20

High-throughput

0.494

High

323422

TRI37
E3 ubiquitin-protein ligase TRIM37

1

20

High-throughput

0.494

High

572018

TRI27
Zinc finger protein RFP

1

20

High-throughput

0.494

High

888788

VPS41
Vacuolar protein sorting-associated protein 41 homolog

1

5

High-throughput

0.494

High

1218718

TRI68
E3 ubiquitin-protein ligase TRIM68

1

20

High-throughput

0.494

High

1218726

CAPS2
Calcium-dependent secretion activator 2

1

6

High-throughput

0.494

High

1218727

DTX1
E3 ubiquitin-protein ligase DTX1

1

20

High-throughput

0.494

High

1218735

KAT6A
Histone acetyltransferase KAT6A

1

2

High-throughput

0.494

High

1218756

TRI34
E3 ubiquitin-protein ligase TRIM34

1

20

High-throughput

0.494

High

63212

VP37C
Vacuolar protein sorting-associated protein 37C

1

3

High-throughput

0.489

High

85995

IGLL5
Immunoglobulin lambda-like polypeptide 5

1

8

High-throughput

0.489

High

366105

THRB
Prothrombin

1

6

High-throughput

0.489

High

366180

HPT
Haptoglobin

1

3

High-throughput

0.489

High

366357

PLMN
Plasminogen

1

5

High-throughput

0.489

High

366582

CFAB
Complement factor B

1

1

High-throughput

0.489

High

369262

ANT3
Antithrombin-III

1

6

High-throughput

0.489

High

369353

A1AT
Alpha-1-antitrypsin

1

6

High-throughput

0.489

High

369467

AACT
Alpha-1-antichymotrypsin

1

6

High-throughput

0.489

High

369547

ANGT
Angiotensinogen

1

7

High-throughput

0.489

High

369682

A2MG
Alpha-2-macroglobulin

1

3

High-throughput

0.489

High

369878

CO3
Complement C3

1

3

High-throughput

0.489

High

369974

CO5
Complement C5

1

3

High-throughput

0.489

High

370416

KNG1
Kininogen-1

1

2

High-throughput

0.489

High

387278

APOA1
Apolipoprotein A-I

1

1

High-throughput

0.489

High

387723

FIBA
Fibrinogen alpha chain [Cleaved into: Fibrinopeptide A; Fibrinogen alpha chain]

1

2

High-throughput

0.489

High

387844

FIBB
Fibrinogen beta chain [Cleaved into: Fibrinopeptide B; Fibrinogen beta chain]

1

2

High-throughput

0.489

High

387974

FIBG
Fibrinogen gamma chain

1

2

High-throughput

0.489

High

388862

A2GL
Leucine-rich alpha-2-glycoprotein

1

1

High-throughput

0.489

High

389417

FINC
Fibronectin

1

2

High-throughput

0.489

High

389660

A1AG1
Alpha-1-acid glycoprotein 1

1

1

High-throughput

0.489

High

389743

FETUA
Alpha-2-HS-glycoprotein

1

2

High-throughput

0.489

High

389835

TTHY
Transthyretin

1

1

High-throughput

0.489

High

390069

ALBU
Albumin

1

1

High-throughput

0.489

High

390292

VTDB
Vitamin D-binding protein

1

1

High-throughput

0.489

High

391143

HEMO
Hemopexin

1

1

High-throughput

0.489

High

399505

C4BPA
C4b-binding protein alpha chain

1

2

High-throughput

0.489

High

399581

VTNC
Vitronectin

1

1

High-throughput

0.489

High

405607

HRG
Histidine-rich glycoprotein

1

3

High-throughput

0.489

High

407006

A1BG
Alpha-1B-glycoprotein

1

2

High-throughput

0.489

High

425224

IC1
Plasma protease C1 inhibitor

1

8

High-throughput

0.489

High

431483

HEP2
Heparin cofactor 2

1

6

High-throughput

0.489

High

467315

CBG
Corticosteroid-binding globulin

1

6

High-throughput

0.489

High

472317

CFAH
Complement factor H

1

2

High-throughput

0.489

High

474742

VIME
Vimentin

1

2

High-throughput

0.489

High

475227

A2AP
Alpha-2-antiplasmin

1

9

High-throughput

0.489

High

515920

SAA2
Serum amyloid A-2 protein

1

1

High-throughput

0.489

High

624707

A1AG2
Alpha-1-acid glycoprotein 2

1

1

High-throughput

0.489

High

626002

ITIH2
Inter-alpha-trypsin inhibitor heavy chain H2

1

2

High-throughput

0.489

High

626053

ITIH1
Inter-alpha-trypsin inhibitor heavy chain H1

1

2

High-throughput

0.489

High

713395

SPB3
Serpin B3

1

5

High-throughput

0.489

High

772087

SAA4
Serum amyloid A-4 protein

1

1

High-throughput

0.489

High

787825

PEDF
Pigment epithelium-derived factor

1

9

High-throughput

0.489

High

874800

SPB4
Serpin B4

1

5

High-throughput

0.489

High

1009663

NGAL
Neutrophil gelatinase-associated lipocalin

1

2

High-throughput

0.489

High

1128880

ITIH4
Inter-alpha-trypsin inhibitor heavy chain H4

1

2

High-throughput

0.489

High

1218736

KLK6
Kallikrein-6

1

1

High-throughput

0.489

High

984154

GBB2
Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2

1

5

High-throughput

0.470

High

476715

RSSA
Small ribosomal subunit protein uS2

1

1

High-throughput

0.417

High

379104

IGKC
Immunoglobulin kappa constant

1

8

High-throughput

0.407

High

379258

IGHG1
Immunoglobulin heavy constant gamma 1

1

9

High-throughput

0.407

High

379361

IGHG2
Immunoglobulin heavy constant gamma 2

1

9

High-throughput

0.407

High

379429

IGHG3
Immunoglobulin heavy constant gamma 3

1

9

High-throughput

0.407

High

379462

IGHG4
Immunoglobulin heavy constant gamma 4

1

11

High-throughput

0.407

High

379526

IGHM
Immunoglobulin heavy constant mu

1

9

High-throughput

0.407

High

379656

IGHA1
Immunoglobulin heavy constant alpha 1

1

8

High-throughput

0.407

High

445458

APOA4
Apolipoprotein A-IV

1

1

High-throughput

0.407

High

501871

CO4B
Complement C4-B

1

3

High-throughput

0.407

High

506524

IGLC6
Immunoglobulin lambda constant 6

1

8

High-throughput

0.407

High

1218769

VPS28
Vacuolar protein sorting-associated protein 28 homolog

3

0

High-throughput

0.347

High

1063327

GOGA2
Golgin subfamily A member 2

2

0

High-throughput

0.334

High

1218743

MB12A
Multivesicular body subunit 12A

2

0

High-throughput

0.328

High

1218753

RNF17
RING finger protein 17

1

0

High-throughput

0.282

High

361537

CERU
Ceruloplasmin

1

0

High-throughput

0.279

Low

387529

APOA2
Apolipoprotein A-II

1

0

High-throughput

0.279

Low

388583

SAMP
Serum amyloid P-component

1

0

High-throughput

0.279

Low

388718

C1QB
Complement C1q subcomponent subunit B

1

0

High-throughput

0.279

Low

388822

CO9
Complement component C9 [Cleaved into: Complement component C9a; Complement component C9b]

1

0

High-throughput

0.279

Low

389603

RET4
Retinol-binding protein 4

1

0

High-throughput

0.279

Low

390902

TRFE
Serotransferrin

1

0

High-throughput

0.279

Low

403180

APOB
Apolipoprotein B-100

1

0

High-throughput

0.279

Low

690585

PON1
Serum paraoxonase/arylesterase 1

1

0

High-throughput

0.279

Low

999365

HBB
Hemoglobin subunit beta

1

0

High-throughput

0.279

Low

1218749

TS101
Tumor susceptibility gene 101 protein

1

0

High-throughput

0.279

Low


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Last updated: 11Aug2025