HitPredict

Interactor 1: P53 (P04637)
Cellular tumor antigen p53 (Antigen NY-CO-13) (Phosphoprotein p53) (Tumor suppressor p53)
Gene: TP53

Interactor 2: PIAS3 (Q9Y6X2)
E3 SUMO-protein ligase PIAS3 (EC 2.3.2.-) (E3 SUMO-protein transferase PIAS3) (Protein inhibitor of activated STAT protein 3)
Gene: PIAS3

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	0.60	0.479

Property	Details
Experiments	34795231
Identification Methods	proximity labelling technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0000122 - negative regulation of transcription by RNA polymerase II GO:0005654 - nucleoplasm GO:0005737 - cytoplasm GO:0006357 - regulation of transcription by RNA polymerase II GO:0008270 - zinc ion binding
Homologous interactions	10

Homologous interactions

Color coding for hit scores

	1 393 Hs			1 628
+	Hs
		277878 P53_HUMAN (1-393): 0: 619: 100.00		PIAS1_HUMAN (1-628): 0: 728: 56.69
+	Mm
		292440 P53_MOUSE (1-393): 0: 589: 77.35		PIAS1_MOUSE (1-628): 0: 729: 57.30
+	Hs
		278208 P53_HUMAN (1-393): 0: 619: 100.00		PIAS2_HUMAN (1-550): 0: 651: 59.00
+	Mm
		356874 P53_MOUSE (1-393): 0: 589: 77.35		PIAS2_MOUSE (1-550): 0: 648: 58.48
+	Hs
		175800 P73_HUMAN (13-362): 2.35e-166: 481: 39.74		PIAS1_HUMAN (1-628): 0: 728: 56.69
+	Hs
		387087 P53_HUMAN (1-393): 0: 619: 100.00		PIAS4_HUMAN (2-477): 2.11e-177: 514: 46.71
+	Mm
		356890 P53_MOUSE (1-393): 0: 589: 77.35		PIAS4_MOUSE (2-443): 4.93e-173: 503: 50.22
+	Hs
		387718 P53_HUMAN (1-393): 0: 619: 100.00		ZMIZ1_HUMAN (79-422): 1.82e-84: 287: 24.93
+	Hs
		387141 P53_HUMAN (1-393): 0: 619: 100.00		ZMIZ2_HUMAN (81-619): 2.53e-79: 271: 20.46
+	Dm
		1341819 Q9N6D8_DROME (124-325): 3.11e-77: 245: 24.31		Q9XYM5_DROME (10-519): 2.07e-161: 474: 42.34