HitPredict

Interactor 1: HSPB1 (P04792)
Heat shock protein beta-1 (HspB1) (28 kDa heat shock protein) (Estrogen-regulated 24 kDa protein) (Heat shock 27 kDa protein) (HSP 27) (Heat shock protein family B member 1) (Stress-responsive protein 27) (SRP27)
Gene: HSPB1

Interactor 2: GATA1 (P15976)
Erythroid transcription factor (Eryf1) (GATA-binding factor 1) (GATA-1) (GF-1) (NF-E1 DNA-binding protein)
Gene: GATA1

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.66	0.60	0.631

Property	Details
Experiments	20410505, 32814053
Identification Methods	affinity chromatography technology, two hybrid, two hybrid array, two hybrid pooling approach, validated two hybrid
Interaction Type	physical association, direct interaction

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus GO:0043066 - negative regulation of apoptotic process GO:0061629 - RNA polymerase II-specific DNA-binding transcription factor binding GO:0070527 - platelet aggregation
Homologous interactions	3

Homologous interactions

Color coding for hit scores

	1 205 Hs			1 413
+	Hs
		358707 CRYAA_HUMAN (21-195): 8.38e-54: 171: 38.42		GATA1_HUMAN (1-413): 3.03e-159: 456: 100.00
+	Hs
		388289 HSPB1_HUMAN (1-205): 4.5e-80: 239: 100.00		GATA4_HUMAN (38-404): 4.35e-65: 216: 30.29
+	Ce
		711323 HSP10_CAEEL (69-171): 8.66e-36: 123: 34.95		ELT2_CAEEL (147-406): 1e-45: 165: 24.55