HitPredict

Interactor 1: HSPB1 (P04792)
Heat shock protein beta-1 (HspB1) (28 kDa heat shock protein) (Estrogen-regulated 24 kDa protein) (Heat shock 27 kDa protein) (HSP 27) (Heat shock protein family B member 1) (Stress-responsive protein 27) (SRP27)
Gene: HSPB1

Interactor 2: GRB2 (P62993)
Growth factor receptor-bound protein 2 (Adapter protein GRB2) (Protein Ash) (SH2/SH3 adapter GRB2)
Gene: GRB2

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.64	0.60	0.624

Property	Details
Experiments	31980649, unassigned2173, 12577067
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation, pull down
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0003723 - RNA binding GO:0005634 - nucleus GO:0005737 - cytoplasm GO:0005829 - cytosol GO:0019901 - protein kinase binding and 1 others more... GO:0070062 - extracellular exosome
Homologous interactions	8

Homologous interactions

Color coding for hit scores

	1 205 Hs			1 217
+	Hs
		388153 HSPB1_HUMAN (1-205): 4.5e-80: 239: 100.00		LCK_HUMAN (3-202): 3.69e-37: 137: 28.91
+	Hs
		388278 HSPB1_HUMAN (1-205): 4.5e-80: 239: 100.00		CSK_HUMAN (2-139): 3.92e-24: 100: 36.24
+	Hs
		388428 HSPB1_HUMAN (1-205): 4.5e-80: 239: 100.00		PTK6_HUMAN (4-141): 7.14e-23: 97.1: 38.93
+	Hs
		388203 HSPB1_HUMAN (1-205): 4.5e-80: 239: 100.00		VAV_HUMAN (2-60): 8.95e-15: 74.6: 42.37
+	Hs
		388158 HSPB1_HUMAN (1-205): 4.5e-80: 239: 100.00		YES_HUMAN (59-215): 4.17e-13: 69.2: 14.91
+	Hs
		388170 HSPB1_HUMAN (1-205): 4.5e-80: 239: 100.00		FGR_HUMAN (120-215): 6.83e-13: 68.8: 22.45
+	Hs
		388165 HSPB1_HUMAN (1-205): 4.5e-80: 239: 100.00		HCK_HUMAN (120-215): 1.21e-12: 68.1: 19.39
+	Ce
		666214 SIP1_CAEEL (47-205): 2.76e-41: 139: 27.61		SEM5_CAEEL (3-69): 6.24e-14: 70: 28.36