HitPredict

Interactor 1: HSPB1 (P04792)
Heat shock protein beta-1 (HspB1) (28 kDa heat shock protein) (Estrogen-regulated 24 kDa protein) (Heat shock 27 kDa protein) (HSP 27) (Heat shock protein family B member 1) (Stress-responsive protein 27) (SRP27)
Gene: HSPB1

Interactor 2: HECD1 (Q9ULT8)
E3 ubiquitin-protein ligase HECTD1 (EC 2.3.2.26) (E3 ligase for inhibin receptor) (EULIR) (HECT domain-containing protein 1)
Gene: HECTD1

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.62	0.50	0.561

Property	Details
Experiments	25277244, 35915203
Identification Methods	two hybrid, affinity chromatography technology, reverse ras recruitment system
Interaction Type	direct interaction, physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	-
Homologous interactions	9

Homologous interactions

Color coding for hit scores

	1 205 Hs			1 2610
+	Hs
		388735 HSPB1_HUMAN (1-205): 4.5e-80: 239: 100.00		SMUF2_HUMAN (2235-2607): 4.78e-118: 395: 20.62
+	Hs
		125080 HSPB1_HUMAN (1-205): 4.5e-80: 239: 100.00		WWP2_HUMAN (2265-2608): 1.64e-107: 368: 24.86
+	Hs
		359059 CRYAB_HUMAN (18-197): 6.14e-51: 164: 39.44		NED4L_HUMAN (2255-2608): 4.26e-117: 399: 21.67
+	Hs
		388717 HSPB1_HUMAN (1-205): 4.5e-80: 239: 100.00		WWP1_HUMAN (2328-2608): 5.47e-91: 321: 29.27
+	Dm
		359101 HSP22_DROME (38-202): 8.39e-33: 117: 28.16		HYD_DROME (2074-2609): 6.27e-104: 376: 17.24
+	Hs
		388207 HSPB1_HUMAN (1-205): 4.5e-80: 239: 100.00		ANK1_HUMAN (354-913): 1.43e-61: 237: 12.27
+	Hs
		388597 HSPB1_HUMAN (1-205): 4.5e-80: 239: 100.00		ANR44_HUMAN (1-265): 2.58e-14: 81.6: 9.52
+	Hs
		358831 CRYAA_HUMAN (21-195): 8.38e-54: 171: 38.42		ANR44_HUMAN (1-265): 2.58e-14: 81.6: 9.52
+	Dm
		409327 HSP6A_DROME (89-204): 4.77e-36: 132: 36.59		Q9VN58_DROME (825-1038): 1.2e-18: 96.3: 22.04