HitPredict

Interactor 1: GNAI2 (P04899)
Guanine nucleotide-binding protein G(i) subunit alpha-2 (Adenylate cyclase-inhibiting G alpha protein)
Gene: GNAI2

Interactor 2: ADRB2 (P07550)
Beta-2 adrenergic receptor (Beta-2 adrenoreceptor) (Beta-2 adrenoceptor)
Gene: ADRB2

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.41	1.00	0.647

Property	Details
Experiments	15782186
Identification Methods	fluorescent resonance energy transfer
Interaction Type	direct interaction

Property	Details
Interacting Pfam domains	7tm_1~G-alpha
Common GO terms	GO:0005886 - plasma membrane GO:0016020 - membrane GO:0098992 - neuronal dense core vesicle
Homologous interactions	10

Homologous interactions

Color coding for hit scores

	1 355 Hs			1 413
+	Hs
		429011 GNAI1_HUMAN (1-355): 8.33e-178: 498: 87.89		ADRB2_HUMAN (1-413): 1.07e-122: 363: 100.00
+	Hs
		428884 GNAI3_HUMAN (1-355): 1.01e-174: 490: 85.92		ADRB2_HUMAN (1-413): 1.07e-122: 363: 100.00
+	Hs
		428911 GNAT2_HUMAN (1-355): 1.04e-166: 470: 69.86		ADRB2_HUMAN (1-413): 1.07e-122: 363: 100.00
+	Hs
		429010 GNAS2_HUMAN (1-355): 1.94e-147: 423: 38.83		ADRB2_HUMAN (1-413): 1.07e-122: 363: 100.00
+	Hs
		450979 GNAO_HUMAN (1-355): 1.03e-173: 488: 69.30		OPRM_HUMAN (5-381): 1.32e-67: 221: 20.57
+	Hs
		580402 GNAZ_HUMAN (1-354): 6.56e-160: 453: 66.38		DRD5_HUMAN (50-348): 3.24e-80: 256: 34.04
+	Hs
		602214 GNA13_HUMAN (2-354): 4.58e-153: 437: 39.72		DRD5_HUMAN (50-348): 3.24e-80: 256: 34.04
+	Hs
		602211 GNAS2_HUMAN (1-355): 1.94e-147: 423: 38.83		DRD5_HUMAN (50-348): 3.24e-80: 256: 34.04
+	Hs
		391310 GNAI2_HUMAN (1-355): 8.42e-180: 504: 100.00		ADA2A_HUMAN (3-229): 5.19e-38: 144: 36.36
+	Hs
		445801 GNAO_HUMAN (1-355): 1.03e-173: 488: 69.30		ADA2A_HUMAN (3-229): 5.19e-38: 144: 36.36