HitPredict

Interactor 1: GNAI2 (P04899)
Guanine nucleotide-binding protein G(i) subunit alpha-2 (Adenylate cyclase-inhibiting G alpha protein)
Gene: GNAI2

Interactor 2: RGS4 (P49798)
Regulator of G-protein signaling 4 (RGP4) (RGS4)
Gene: RGS4

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.41	1.00	0.647

Property	Details
Experiments	9660808
Identification Methods	pull down
Interaction Type	direct interaction

Property	Details
Interacting Pfam domains	G-alpha~RGS
Common GO terms	GO:0003924 - GTPase activity GO:0005737 - cytoplasm GO:0005886 - plasma membrane GO:0007186 - G protein-coupled receptor signaling pathway GO:0051924 - regulation of calcium ion transport
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 355 Hs			1 205
+	Rn
		500350 GNAI1_RAT (1-355): 6.55e-178: 499: 87.89		RGS4_RAT (1-205): 1.71e-83: 248: 97.07
+	Hs
		834937 GNAI1_HUMAN (1-355): 8.33e-178: 498: 87.89		RGS4_HUMAN (1-205): 8.99e-84: 248: 100.00
+	Hs
		391357 GNAI2_HUMAN (1-355): 8.42e-180: 504: 100.00		RGS3_HUMAN (16-184): 3.99e-65: 218: 52.66
+	Hs
		182439 GNAI2_HUMAN (1-355): 8.42e-180: 504: 100.00		RGS5_HUMAN (1-179): 1.24e-70: 214: 52.49
+	Hs
		180650 GNAI2_HUMAN (1-355): 8.42e-180: 504: 100.00		RGS16_HUMAN (1-177): 2.47e-69: 211: 49.44
+	Hs
		182448 GNAI1_HUMAN (1-355): 8.33e-178: 498: 87.89		RGS5_HUMAN (1-179): 1.24e-70: 214: 52.49
+	Hs
		180657 GNAI1_HUMAN (1-355): 8.33e-178: 498: 87.89		RGS16_HUMAN (1-177): 2.47e-69: 211: 49.44
+	Hs
		391473 GNAI2_HUMAN (1-355): 8.42e-180: 504: 100.00		RGS18_HUMAN (15-200): 5.06e-63: 197: 43.55
+	Hs
		283156 GNAI2_HUMAN (1-355): 8.42e-180: 504: 100.00		RGS20_HUMAN (26-185): 4.74e-61: 196: 38.65
+	Hs
		926720 GNAI1_HUMAN (1-355): 8.33e-178: 498: 87.89		RGS18_HUMAN (15-200): 5.06e-63: 197: 43.55
+	Hs
		283183 GNAI1_HUMAN (1-355): 8.33e-178: 498: 87.89		RGS20_HUMAN (26-185): 4.74e-61: 196: 38.65
+	Hs
		391356 GNAI2_HUMAN (1-355): 8.42e-180: 504: 100.00		RGS19_HUMAN (27-188): 2.18e-60: 189: 36.42
+	Hs
		834879 GNAI1_HUMAN (1-355): 8.33e-178: 498: 87.89		RGS19_HUMAN (27-188): 2.18e-60: 189: 36.42
+	Hs
		158580 GNAI2_HUMAN (1-355): 8.42e-180: 504: 100.00		RGS13_HUMAN (32-186): 1.91e-58: 182: 41.29
+	Hs
		926723 GNAI1_HUMAN (1-355): 8.33e-178: 498: 87.89		RGS17_HUMAN (28-188): 4.23e-60: 188: 32.93
+	Hs
		158597 GNAI2_HUMAN (1-355): 8.42e-180: 504: 100.00		RGS12_HUMAN (44-178): 3.37e-52: 181: 38.69
+	Hs
		207505 GNAI2_HUMAN (1-355): 8.42e-180: 504: 100.00		RGS14_HUMAN (18-198): 1.03e-53: 181: 30.98
+	Hs
		158608 GNAI1_HUMAN (1-355): 8.33e-178: 498: 87.89		RGS12_HUMAN (44-178): 3.37e-52: 181: 38.69
+	Hs
		207517 GNAI1_HUMAN (1-355): 8.33e-178: 498: 87.89		RGS14_HUMAN (18-198): 1.03e-53: 181: 30.98
+	Hs
		210414 GNAI1_HUMAN (1-355): 8.33e-178: 498: 87.89		RGS10_HUMAN (58-175): 1.57e-25: 99.4: 44.92