Protein: FRIH
Ferritin heavy chain (Ferritin H subunit) (EC 1.16.3.1) (Cell proliferation-inducing gene 15 protein) [Cleaved into: Ferritin heavy chain, N-terminally processed]

Gene: FRIH, FTH1
Organism: Homo sapiens
Interactions: 180
UniProt ID: P02794

Gene Ontology (top 5):
GO:0004322 - ferroxidase activity
GO:0005506 - iron ion binding
GO:0005576 - extracellular region
GO:0005634 - nucleus
GO:0005737 - cytoplasm

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

391169

FRIL
Ferritin light chain

10

16

High-throughput

0.981

High

391535

FRIH
Ferritin heavy chain

3

15

Small-scale

0.833

High

391613

NCOA4
Nuclear receptor coactivator 4

7

2

Small-scale

0.750

High

391592

FXR2
RNA-binding protein FXR2

3

1

High-throughput

0.666

High

391645

TSC1
Hamartin

2

3

Small-scale

0.634

High

210670

KLK10
Kallikrein-10

2

4

High-throughput

0.628

High

220073

TGM5
Protein-glutamine gamma-glutamyltransferase 5

2

2

High-throughput

0.628

High

248653

PEPL
Periplakin

2

1

High-throughput

0.628

High

261583

CATL2
Cathepsin L2

2

1

High-throughput

0.628

High

289237

SPB7
Serpin B7

2

5

High-throughput

0.628

High

370052

CYTS
Cystatin-S

2

3

High-throughput

0.628

High

391538

SEMG1
Semenogelin-1

2

1

High-throughput

0.628

High

391541

INVO
Involucrin

2

1

High-throughput

0.628

High

391562

IL1RA
Interleukin-1 receptor antagonist protein

2

1

High-throughput

0.628

High

391564

FILA
Filaggrin

2

3

High-throughput

0.628

High

391566

TGM1
Protein-glutamine gamma-glutamyltransferase K

2

2

High-throughput

0.628

High

391572

SPB3
Serpin B3

2

4

High-throughput

0.628

High

391586

SPB4
Serpin B4

2

4

High-throughput

0.628

High

391589

KLK7
Kallikrein-7

2

3

High-throughput

0.628

High

391607

SEMG2
Semenogelin-2

2

1

High-throughput

0.628

High

391608

TGM3
Protein-glutamine gamma-glutamyltransferase E

2

2

High-throughput

0.628

High

391638

RDHE2
Epidermal retinol dehydrogenase 2

2

1

High-throughput

0.628

High

391666

IL37
Interleukin-37

2

1

High-throughput

0.628

High

391668

CRNN
Cornulin

2

2

High-throughput

0.628

High

391669

KLK11
Kallikrein-11

2

3

High-throughput

0.628

High

391677

KLK5
Kallikrein-5

2

3

High-throughput

0.628

High

391671

DAXX
Death domain-associated protein 6

2

0

Small-scale

0.614

High

276556

LX12B
Arachidonate 12-lipoxygenase, 12R-type

2

0

High-throughput

0.602

High

389593

RET4
Retinol-binding protein 4

2

0

High-throughput

0.602

High

391557

PPAP
Prostatic acid phosphatase

2

0

High-throughput

0.602

High

391574

CASPE
Caspase-14

2

0

High-throughput

0.602

High

391581

HUTH
Histidine ammonia-lyase

2

0

High-throughput

0.602

High

391625

PLBL1
Phospholipase B-like 1

2

0

High-throughput

0.602

High

391656

TREX2
Three prime repair exonuclease 2

2

0

High-throughput

0.602

High

169883

AURKA
Aurora kinase A

2

5

High-throughput

0.584

High

391650

AURKB
Aurora kinase B

2

5

High-throughput

0.584

High

391540

HSPB1
Heat shock protein beta-1

1

3

High-throughput

0.582

High

336609

BAG4
BAG family molecular chaperone regulator 4

2

0

High-throughput

0.580

High

391600

MAX
Protein max

1

6

High-throughput

0.578

High

140106

SDCB1
Syntenin-1

2

3

High-throughput

0.576

High

391651

NTAQ1
Protein N-terminal glutamine amidohydrolase

2

2

High-throughput

0.576

High

391633

SPA12
Serpin A12

2

4

High-throughput

0.574

High

391672

CBPA4
Carboxypeptidase A4

2

2

High-throughput

0.574

High

342716

HERC2
E3 ubiquitin-protein ligase HERC2

2

1

High-throughput

0.571

High

391616

PCBP1
Poly(rC)-binding protein 1

1

2

Small-scale

0.561

High

391617

PCBP2
Poly(rC)-binding protein 2

1

2

Small-scale

0.561

High

69466

A2ML1
Alpha-2-macroglobulin-like protein 1

2

1

High-throughput

0.552

High

391678

LC7L2
Putative RNA-binding protein Luc7-like 2

2

2

High-throughput

0.549

High

391545

MYL3
Myosin light chain 3

1

1

High-throughput

0.541

High

391591

FXR1
RNA-binding protein FXR1

1

1

High-throughput

0.541

High

391606

DLG4
Disks large homolog 4

1

1

High-throughput

0.541

High

391649

OPTN
Optineurin

1

2

High-throughput

0.541

High

391664

BRD7
Bromodomain-containing protein 7

1

2

High-throughput

0.541

High

391605

SHPS1
Tyrosine-protein phosphatase non-receptor type substrate 1

1

0

Small-scale

0.537

High

299018

FLOT1
Flotillin-1

1

3

High-throughput

0.536

High

370130

CYTN
Cystatin-SN

1

3

High-throughput

0.536

High

391542

YES
Tyrosine-protein kinase Yes

1

2

High-throughput

0.536

High

391543

LYN
Tyrosine-protein kinase Lyn

1

2

High-throughput

0.536

High

391548

RAP2A
Ras-related protein Rap-2a

1

2

High-throughput

0.536

High

391553

CFTR
Cystic fibrosis transmembrane conductance regulator

1

1

High-throughput

0.536

High

391556

CBPM
Carboxypeptidase M

1

2

High-throughput

0.536

High

391571

CALL3
Calmodulin-like protein 3

1

1

High-throughput

0.536

High

391577

SPB5
Serpin B5

1

4

High-throughput

0.536

High

391584

MK09
Mitogen-activated protein kinase 9

1

1

High-throughput

0.536

High

391609

AIMP1
Aminoacyl tRNA synthase complex-interacting multifunctional protein 1

1

1

High-throughput

0.536

High

391618

CYTM
Cystatin-M

1

3

High-throughput

0.536

High

391622

FILA2
Filaggrin-2

1

3

High-throughput

0.536

High

391646

VPP1
V-type proton ATPase 116 kDa subunit a 1

1

1

High-throughput

0.536

High

391653

CPNS2
Calpain small subunit 2

1

2

High-throughput

0.536

High

391667

CALL5
Calmodulin-like protein 5

1

2

High-throughput

0.536

High

391673

SPB13
Serpin B13

1

4

High-throughput

0.536

High

391679

RAP2C
Ras-related protein Rap-2c

1

2

High-throughput

0.536

High

391680

VPP2
V-type proton ATPase 116 kDa subunit a 2

1

1

High-throughput

0.536

High

75647

B3KVV6
cDNA FLJ41607 fis, clone CTONG3001370, highly similar to Homo sapiens alpha-2-macroglobulin-like 1

2

1

High-throughput

0.533

High

391573

MPIP1
M-phase inducer phosphatase 1

1

0

High-throughput

0.518

High

391576

SOX5
Transcription factor SOX-5

1

0

High-throughput

0.518

High

391614

DPYL1
Dihydropyrimidinase-related protein 1

1

0

High-throughput

0.518

High

391634

UBR1
E3 ubiquitin-protein ligase UBR1

1

0

High-throughput

0.518

High

391658

PACN1
Protein kinase C and casein kinase substrate in neurons protein 1

1

0

High-throughput

0.518

High

391660

TOLIP
Toll-interacting protein

1

0

High-throughput

0.518

High

391662

ELL3
RNA polymerase II elongation factor ELL3

1

0

High-throughput

0.518

High

238848

DHX16
Pre-mRNA-splicing factor ATP-dependent RNA helicase DHX16

1

0

High-throughput

0.513

High

291618

XRP2
Protein XRP2

1

0

High-throughput

0.513

High

391554

PLSL
Plastin-2

1

0

High-throughput

0.513

High

391559

KPCA
Protein kinase C alpha type

1

0

High-throughput

0.513

High

391560

SAP3
Ganglioside GM2 activator

1

0

High-throughput

0.513

High

391565

PRPS3
Ribose-phosphate pyrophosphokinase 3

1

0

High-throughput

0.513

High

391569

ZA2G
Zinc-alpha-2-glycoprotein

1

0

High-throughput

0.513

High

391570

RS12
Small ribosomal subunit protein eS12

1

0

High-throughput

0.513

High

391583

MATR3
Matrin-3

1

0

High-throughput

0.513

High

391585

MAOX
NADP-dependent malic enzyme

1

0

High-throughput

0.513

High

391601

RS8
Small ribosomal subunit protein eS8

1

0

High-throughput

0.513

High

391612

ASAH1
Acid ceramidase

1

0

High-throughput

0.513

High

391620

ECM1
Extracellular matrix protein 1

1

0

High-throughput

0.513

High

391626

SBSN
Suprabasin

1

0

High-throughput

0.513

High

391628

FBX50
F-box only protein 50

1

0

High-throughput

0.513

High

391635

MSRB3
Methionine-R-sulfoxide reductase B3

1

0

High-throughput

0.513

High

391655

GSDMA
Gasdermin-A

1

0

High-throughput

0.513

High

391676

GUAD
Guanine deaminase

1

0

High-throughput

0.513

High

391682

DC1L1
Cytoplasmic dynein 1 light intermediate chain 1

1

0

High-throughput

0.513

High

391568

GATA3
Trans-acting T-cell-specific transcription factor GATA-3

1

1

High-throughput

0.500

High

390407

TFR1
Transferrin receptor protein 1

1

0

Small-scale

0.494

High

391663

GPR35
G-protein coupled receptor 35

1

1

High-throughput

0.494

High

391537

GCR
Glucocorticoid receptor

1

1

High-throughput

0.481

High

391578

SYUA
Alpha-synuclein

1

1

High-throughput

0.481

High

391594

IMA1
Importin subunit alpha-1

1

5

High-throughput

0.481

High

391603

GRB2
Growth factor receptor-bound protein 2

1

4

High-throughput

0.481

High

391615

NR1I3
Nuclear receptor subfamily 1 group I member 3

1

1

High-throughput

0.481

High

391657

TRAF4
TNF receptor-associated factor 4

1

1

Small-scale

0.481

High

391580

STAT1
Signal transducer and activator of transcription 1-alpha/beta

1

0

Small-scale

0.480

High

391598

CDC42
Cell division control protein 42 homolog

1

0

High-throughput

0.480

High

323078

TRI37
E3 ubiquitin-protein ligase TRIM37

1

2

High-throughput

0.479

High

370881

MYC
Myc proto-oncogene protein

1

6

High-throughput

0.479

High

391536

RAF1
RAF proto-oncogene serine/threonine-protein kinase

1

2

High-throughput

0.479

High

391544

HS90B
Heat shock protein HSP 90-beta

1

2

High-throughput

0.479

High

391546

UBC
Polyubiquitin-C [Cleaved into: Ubiquitin]

1

3

Small-scale

0.479

High

391558

VATB1
V-type proton ATPase subunit B, kidney isoform

1

2

High-throughput

0.479

High

391595

PCBP3
Poly(rC)-binding protein 3

1

2

Small-scale

0.479

High

391596

NLRP6
NACHT, LRR and PYD domains-containing protein 6

1

1

High-throughput

0.479

High

391611

SQSTM
Sequestosome-1

1

4

High-throughput

0.479

High

391627

TRI67
Tripartite motif-containing protein 67

1

3

High-throughput

0.479

High

391630

TAXB1
Tax1-binding protein 1

1

3

High-throughput

0.479

High

391632

CEP57
Centrosomal protein of 57 kDa

1

1

High-throughput

0.479

High

391644

ASB15
Ankyrin repeat and SOCS box protein 15

1

2

High-throughput

0.479

High

391647

IGSF8
Immunoglobulin superfamily member 8

1

2

High-throughput

0.479

High

391654

ASB16
Ankyrin repeat and SOCS box protein 16

1

1

High-throughput

0.479

High

391659

MLP3B
Microtubule-associated protein 1 light chain 3 beta

1

2

High-throughput

0.479

High

391661

GBRL1
Gamma-aminobutyric acid receptor-associated protein-like 1

1

2

Small-scale

0.479

High

391681

UCHL5
Ubiquitin carboxyl-terminal hydrolase isozyme L5

1

1

Small-scale

0.479

High

137523

NR5A2
Nuclear receptor subfamily 5 group A member 2

1

0

High-throughput

0.460

High

391549

OSTP
Osteopontin

1

0

Small-scale

0.460

High

391555

CD99
CD99 antigen

1

0

Small-scale

0.460

High

391561

LBP
Lipopolysaccharide-binding protein

1

0

High-throughput

0.460

High

391602

1433E
14-3-3 protein epsilon

1

0

High-throughput

0.460

High

391604

CSK2B
Casein kinase II subunit beta

1

0

High-throughput

0.460

High

391610

CDC16
Cell division cycle protein 16 homolog

1

0

High-throughput

0.460

High

391637

PIAS4
E3 SUMO-protein ligase PIAS4

1

0

High-throughput

0.460

High

391539

P53
Cellular tumor antigen p53

1

0

High-throughput

0.458

High

391547

SCHI1
Schwannomin-interacting protein 1

1

0

High-throughput

0.458

High

391552

CADH1
Cadherin-1

1

0

High-throughput

0.458

High

391563

BTF3
Transcription factor BTF3

1

0

High-throughput

0.458

High

391590

PPT1
Palmitoyl-protein thioesterase 1

1

0

High-throughput

0.458

High

391593

MECP2
Methyl-CpG-binding protein 2

1

0

High-throughput

0.458

High

391599

CXCR4
C-X-C chemokine receptor type 4

1

0

Small-scale

0.458

High

391619

E2F4
Transcription factor E2F4

1

0

High-throughput

0.458

High

391624

VIR
Protein virilizer homolog

1

0

High-throughput

0.458

High

391597

NAL12
NACHT, LRR and PYD domains-containing protein 12

1

1

Small-scale

0.457

High

391652

SPTCS
Spatacsin

1

1

Small-scale

0.457

High

58786

PIPSL
Putative PIP5K1A and PSMD4-like protein

1

3

High-throughput

0.445

High

69754

ZN785
Zinc finger protein 785

1

1

High-throughput

0.445

High

76600

B4DZ85
Nuclear receptor coactivator 4

1

2

High-throughput

0.445

High

171825

ZN263
Zinc finger protein 263

1

1

High-throughput

0.445

High

391550

TAU
Microtubule-associated protein tau

1

1

Small-scale

0.445

High

391567

HEMH
Ferrochelatase, mitochondrial

1

1

High-throughput

0.445

High

391575

BMI1
Polycomb complex protein BMI-1

1

1

High-throughput

0.445

High

391579

VATA
V-type proton ATPase catalytic subunit A

1

3

High-throughput

0.445

High

391582

RL35
Large ribosomal subunit protein uL29

1

1

High-throughput

0.445

High

391588

RGS3
Regulator of G-protein signaling 3

1

1

High-throughput

0.445

High

391621

INAVA
Innate immunity activator protein

1

2

High-throughput

0.445

High

391623

DJC21
DnaJ homolog subfamily C member 21

1

1

High-throughput

0.445

High

391639

POC5
Centrosomal protein POC5

1

1

High-throughput

0.445

High

391642

TGFA1
Transforming growth factor-beta receptor-associated protein 1

1

1

High-throughput

0.445

High

391551

CLUS
Clusterin

1

0

High-throughput

0.438

High

105087

APRIO
Alternative prion protein

1

1

High-throughput

0.437

High

391665

NLE1
Notchless protein homolog 1

1

3

High-throughput

0.437

High

379063

IGKC
Immunoglobulin kappa constant

1

0

High-throughput

0.426

High

391670

CLIP2
CAP-Gly domain-containing linker protein 2

1

0

High-throughput

0.426

High

391674

ZN223
Zinc finger protein 223

1

0

High-throughput

0.426

High

330016

VENTX
Homeobox protein VENTX

1

2

High-throughput

0.407

High

391643

POF1B
Protein POF1B

2

0

High-throughput

0.328

High

391640

GOLM1
Golgi membrane protein 1

1

0

High-throughput

0.282

High

391587

ACADV
Very long-chain specific acyl-CoA dehydrogenase, mitochondrial

1

0

High-throughput

0.279

Low

391629

MD13L
Mediator of RNA polymerase II transcription subunit 13-like

1

0

High-throughput

0.279

Low

391648

SNX21
Sorting nexin-21

1

0

High-throughput

0.279

Low

391675

LTOR2
Ragulator complex protein LAMTOR2

1

0

High-throughput

0.279

Low

391631

TCAM2
TIR domain-containing adapter molecule 2

1

0

High-throughput

0.251

Low

350761

TRUB2
Pseudouridylate synthase TRUB2, mitochondrial

1

0

High-throughput

0.249

Low

391636

TM192
Transmembrane protein 192

1

0

High-throughput

0.249

Low

391641

MIPT3
TRAF3-interacting protein 1

1

0

High-throughput

0.238

Low


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Last updated: 11Aug2025