HitPredict

Interactor 1: H2A2 (P04912)
Histone H2A.2
Gene: HTA2

Interactor 2: MCM2 (P29469)
DNA replication licensing factor MCM2 (EC 3.6.4.12) (Minichromosome maintenance protein 2)
Gene: MCM2

Species: Saccharomyces cerevisiae S288C

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.66	1.00	0.817

Property	Details
Experiments	23499444, 19106085, 21179020
Identification Methods	affinity chromatography technology, tandem affinity purification
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	Histone~MCM2_N
Common GO terms	GO:0005634 - nucleus GO:0031298 - replication fork protection complex
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 132 Sc			1 868
+	Hs
		832655 H2A1A_HUMAN (3-130): 1.25e-64: 194: 74.22		MCM2_HUMAN (16-865): 0: 933: 46.96
+	Hs
		832672 H2A1J_HUMAN (3-128): 1.79e-63: 191: 74.60		MCM2_HUMAN (16-865): 0: 933: 46.96
+	Hs
		832567 H2A2B_HUMAN (3-127): 3.9e-63: 190: 74.40		MCM2_HUMAN (16-865): 0: 933: 46.96
+	Hs
		832648 H2A1H_HUMAN (3-128): 3.42e-63: 190: 75.40		MCM2_HUMAN (16-865): 0: 933: 46.96
+	Hs
		832683 H2AJ_HUMAN (3-130): 3.28e-63: 190: 73.44		MCM2_HUMAN (16-865): 0: 933: 46.96
+	Hs
		594831 H2A1D_HUMAN (3-128): 1.18e-62: 189: 74.60		MCM2_HUMAN (16-865): 0: 933: 46.96
+	Hs
		832548 H2A3_HUMAN (3-128): 9.58e-63: 189: 75.40		MCM2_HUMAN (16-865): 0: 933: 46.96
+	Hs
		832623 H2A1C_HUMAN (3-128): 8.4e-63: 189: 76.19		MCM2_HUMAN (16-865): 0: 933: 46.96
+	Hs
		708736 H2A1A_HUMAN (3-130): 1.25e-64: 194: 74.22		MCM5_HUMAN (206-863): 0: 718: 32.33
+	Hs
		708748 H2A1J_HUMAN (3-128): 1.79e-63: 191: 74.60		MCM5_HUMAN (206-863): 0: 718: 32.33
+	Hs
		708697 H2A2B_HUMAN (3-127): 3.9e-63: 190: 74.40		MCM5_HUMAN (206-863): 0: 718: 32.33
+	Hs
		708733 H2A1H_HUMAN (3-128): 3.42e-63: 190: 75.40		MCM5_HUMAN (206-863): 0: 718: 32.33
+	Hs
		708755 H2AJ_HUMAN (3-130): 3.28e-63: 190: 73.44		MCM5_HUMAN (206-863): 0: 718: 32.33
+	Hs
		594826 H2A1D_HUMAN (3-128): 1.18e-62: 189: 74.60		MCM5_HUMAN (206-863): 0: 718: 32.33
+	Hs
		708663 H2A2C_HUMAN (3-130): 9.18e-63: 189: 73.44		MCM5_HUMAN (206-863): 0: 718: 32.33
+	Hs
		708693 H2A3_HUMAN (3-128): 9.58e-63: 189: 75.40		MCM5_HUMAN (206-863): 0: 718: 32.33
+	Hs
		708718 H2A1C_HUMAN (3-128): 8.4e-63: 189: 76.19		MCM5_HUMAN (206-863): 0: 718: 32.33
+	Sc
		392336 H2A2_YEAST (1-132): 1.1e-62: 189: 100.00		MCM4_YEAST (38-851): 0: 672: 25.54
+	Sc
		392308 H2A2_YEAST (1-132): 1.1e-62: 189: 100.00		MCM3_YEAST (305-833): 2.8e-87: 300: 37.65
+	Sc
		392334 H2A2_YEAST (1-132): 1.1e-62: 189: 100.00		MCM5_YEAST (207-848): 1.04e-85: 291: 32.24