HitPredict

Interactor 1: IFNA4 (P05014)
Interferon alpha-4 (IFN-alpha-4) (Interferon alpha-4B) (Interferon alpha-76) (Interferon alpha-M1)
Gene: IFNA4

Interactor 2: ISG15 (P05161)
Ubiquitin-like protein ISG15 (Interferon-induced 15 kDa protein) (Interferon-induced 17 kDa protein) (IP17) (Ubiquitin cross-reactive protein) (hUCRP)
Gene: ISG15

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.65	0.60	0.628

Property	Details
Experiments	28514442, 33961781
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005576 - extracellular region GO:0009615 - response to virus GO:0051607 - defense response to virus
Homologous interactions	9

Homologous interactions

Color coding for hit scores

	1 189 Hs			1 165
+	Hs
		352823 IFNA5_HUMAN (1-189): 4.11e-104: 298: 83.60		ISG15_HUMAN (1-165): 2.83e-48: 155: 100.00
+	Hs
		352778 IFN10_HUMAN (1-189): 5.23e-103: 296: 95.77		ISG15_HUMAN (1-165): 2.83e-48: 155: 100.00
+	Hs
		352796 IFN21_HUMAN (1-189): 1.2e-101: 292: 92.06		ISG15_HUMAN (1-165): 2.83e-48: 155: 100.00
+	Hs
		352744 IFNA1_HUMAN (1-189): 1.74e-100: 289: 79.89		ISG15_HUMAN (1-165): 2.83e-48: 155: 100.00
+	Hs
		352835 IFN14_HUMAN (1-189): 6.02e-100: 288: 84.13		ISG15_HUMAN (1-165): 2.83e-48: 155: 100.00
+	Hs
		352785 IFNA7_HUMAN (1-189): 8.73e-100: 287: 93.65		ISG15_HUMAN (1-165): 2.83e-48: 155: 100.00
+	Hs
		352765 IFNA2_HUMAN (1-189): 1.13e-94: 275: 81.48		ISG15_HUMAN (1-165): 2.83e-48: 155: 100.00
+	Hs
		397809 IFNA8_HUMAN (1-189): 1.77e-94: 274: 81.48		ISG15_HUMAN (1-165): 2.83e-48: 155: 100.00
+	Hs
		392905 IFNW1_HUMAN (12-189): 1.01e-80: 239: 57.87		ISG15_HUMAN (1-165): 2.83e-48: 155: 100.00