Protein: AFF4
AF4/FMR2 family member 4 (ALL1-fused gene from chromosome 5q31 protein) (Protein AF-5q31) (Major CDK9 elongation factor-associated protein)

Gene: AFF4
Organism: Homo sapiens
Interactions: 100
UniProt ID: Q9UHB7

Gene Ontology (top 5):
GO:0000791 - euchromatin
GO:0001650 - fibrillar center
GO:0005654 - nucleoplasm
GO:0007286 - spermatid development
GO:0008023 - transcription elongation factor complex

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

841922

CDK9
Cyclin-dependent kinase 9

15

13

Small-scale

0.985

High

974525

ENL
Protein ENL

7

16

Small-scale

0.970

High

236846

CCNT1
Cyclin-T1

7

2

Small-scale

0.967

High

130172

ELL2
RNA polymerase II elongation factor ELL2

7

16

Small-scale

0.966

High

788073

AF9
Protein AF-9

6

11

Small-scale

0.946

High

237418

CCNT2
Cyclin-T2

4

2

High-throughput

0.903

High

876672

ELL
RNA polymerase II elongation factor ELL

4

12

High-throughput

0.903

High

1335107

ELL3
RNA polymerase II elongation factor ELL3

3

12

High-throughput

0.861

High

850828

AFF1
AF4/FMR2 family member 1

2

16

Small-scale

0.811

High

1241325

CAMKV
CaM kinase-like vesicle-associated protein

2

5

High-throughput

0.726

High

1286799

EAF2
ELL-associated factor 2

4

2

High-throughput

0.699

High

1295120

EAF1
ELL-associated factor 1

4

2

High-throughput

0.699

High

303524

HEXI1
Protein HEXIM1

3

1

High-throughput

0.667

High

1224950

FAM9A
Protein FAM9A

3

1

High-throughput

0.667

High

1332224

DEN2D
DENN domain-containing protein 2D

3

1

High-throughput

0.667

High

1020969

TRAF2
TNF receptor-associated factor 2

2

6

High-throughput

0.633

High

817767

PI42A
Phosphatidylinositol 5-phosphate 4-kinase type-2 alpha

2

3

High-throughput

0.628

High

1130696

LRRK2
Leucine-rich repeat serine/threonine-protein kinase 2

1

8

High-throughput

0.619

High

794436

GRK6
G protein-coupled receptor kinase 6

1

2

High-throughput

0.618

High

1300121

CDK15
Cyclin-dependent kinase 15

1

4

High-throughput

0.618

High

415094

CDK1
Cyclin-dependent kinase 1

1

2

High-throughput

0.618

High

960339

CDK5
Cyclin-dependent kinase 5

1

3

High-throughput

0.618

High

1348692

CDK12
Cyclin-dependent kinase 12

1

13

High-throughput

0.618

High

975340

KMT2A
Histone-lysine N-methyltransferase 2A

2

20

Small-scale

0.611

High

132236

PESC
Pescadillo homolog

2

0

High-throughput

0.602

High

686091

ARRB2
Beta-arrestin-2

2

0

High-throughput

0.602

High

313474

MED26
Mediator of RNA polymerase II transcription subunit 26

2

1

High-throughput

0.601

High

935344

H31
Histone H3.1

2

18

High-throughput

0.584

High

1216728

SIAH1
E3 ubiquitin-protein ligase SIAH1

2

10

High-throughput

0.578

High

370646

ESR1
Estrogen receptor

2

20

High-throughput

0.571

High

1271600

EDA
Ectodysplasin-A

2

4

High-throughput

0.558

High

375048

RAF1
RAF proto-oncogene serine/threonine-protein kinase

1

10

High-throughput

0.553

High

714598

GRK5
G protein-coupled receptor kinase 5

1

2

High-throughput

0.553

High

48740

MED19
Mediator of RNA polymerase II transcription subunit 19

2

0

High-throughput

0.547

High

659745

RXRB
Retinoic acid receptor RXR-beta

1

20

High-throughput

0.536

High

1160990

CTR9
RNA polymerase-associated protein CTR9 homolog

1

6

High-throughput

0.536

High

1232293

PLCD3
1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-3

1

4

High-throughput

0.536

High

1253130

PI42C
Phosphatidylinositol 5-phosphate 4-kinase type-2 gamma

1

3

High-throughput

0.536

High

1336364

E41L5
Band 4.1-like protein 5

1

15

High-throughput

0.536

High

1347783

LYAR
Cell growth-regulating nucleolar protein

1

1

High-throughput

0.536

High

1353916

IKBL1
NF-kappa-B inhibitor-like protein 1

1

1

High-throughput

0.536

High

1354560

DAXX
Death domain-associated protein 6

1

2

High-throughput

0.536

High

926044

AP2B1
AP-2 complex subunit beta

1

2

High-throughput

0.523

High

995283

GOGA2
Golgin subfamily A member 2

1

4

High-throughput

0.523

High

1127198

MTUS2
Microtubule-associated tumor suppressor candidate 2

1

7

High-throughput

0.523

High

470197

H2AZ
Histone H2A.Z

1

6

High-throughput

0.515

High

559280

H15
Histone H1.5

1

7

High-throughput

0.515

High

1274468

H2B1H
Histone H2B type 1-H

1

14

High-throughput

0.515

High

1238275

JMY
Junction-mediating and -regulatory protein

1

0

High-throughput

0.513

High

133057

SDCB1
Syntenin-1

1

3

Small-scale

0.501

High

899688

FGF12
Fibroblast growth factor 12

1

2

High-throughput

0.489

High

1070198

RASA2
Ras GTPase-activating protein 2

1

4

High-throughput

0.489

High

1101024

RN151
RING finger protein 151

1

7

High-throughput

0.489

High

1201407

LRRT4
Leucine-rich repeat transmembrane neuronal protein 4

1

1

High-throughput

0.489

High

1238304

F133A
Protein FAM133A

1

1

High-throughput

0.489

High

1238366

SYT2
Synaptotagmin-2

1

2

High-throughput

0.489

High

1309952

PLCD4
1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-4

1

4

High-throughput

0.489

High

1331055

E41L1
Band 4.1-like protein 1

1

15

High-throughput

0.489

High

1355296

E41L3
Band 4.1-like protein 3

1

16

High-throughput

0.489

High

133718

NOP56
Nucleolar protein 56

1

1

High-throughput

0.479

High

170503

TIF1A
Transcription intermediary factor 1-alpha

1

14

High-throughput

0.479

High

179873

RPA34
DNA-directed RNA polymerase I subunit RPA34

1

10

High-throughput

0.479

High

348159

MYC
Myc proto-oncogene protein

1

14

High-throughput

0.479

High

455973

PARP1
Poly [ADP-ribose] polymerase 1

1

15

High-throughput

0.479

High

487818

ANDR
Androgen receptor

1

20

High-throughput

0.479

High

524062

XRCC6
X-ray repair cross-complementing protein 6

1

4

High-throughput

0.479

High

653021

APEX1
DNA repair nuclease/redox regulator APEX1

1

3

High-throughput

0.479

High

750520

COIL
Coilin

1

2

High-throughput

0.479

High

952682

H33
Histone H3.3

1

18

High-throughput

0.479

High

970046

KIF23
Kinesin-like protein KIF23

1

15

High-throughput

0.479

High

1052040

ELOA1
Elongin-A

1

6

Small-scale

0.479

High

1055503

DHX8
ATP-dependent RNA helicase DHX8

1

2

High-throughput

0.479

High

1200728

NAA40
N-alpha-acetyltransferase 40

1

5

High-throughput

0.479

High

1221807

SMC5
Structural maintenance of chromosomes protein 5

1

12

High-throughput

0.479

High

1222626

SLX4
Structure-specific endonuclease subunit SLX4

1

14

High-throughput

0.479

High

1242681

TNR6A
Trinucleotide repeat-containing gene 6A protein

1

14

Small-scale

0.479

High

1270972

KAT6A
Histone acetyltransferase KAT6A

1

6

High-throughput

0.479

High

1273948

UBP7
Ubiquitin carboxyl-terminal hydrolase 7

1

6

Small-scale

0.479

High

1313208

DDX23
Probable ATP-dependent RNA helicase DDX23

1

4

High-throughput

0.479

High

1316927

MK67I
MKI67 FHA domain-interacting nucleolar phosphoprotein

1

4

High-throughput

0.479

High

1328287

CCDC8
Coiled-coil domain-containing protein 8

1

5

High-throughput

0.479

High

1335095

SP110
Sp110 nuclear body protein

1

14

High-throughput

0.479

High

1348369

TE2IP
Telomeric repeat-binding factor 2-interacting protein 1

1

4

High-throughput

0.479

High

1354750

ZRAN1
Ubiquitin thioesterase ZRANB1

1

10

High-throughput

0.479

High

1355297

ZN330
Zinc finger protein 330

1

2

High-throughput

0.479

High

989167

FMR1
Fragile X messenger ribonucleoprotein 1

1

13

High-throughput

0.457

High

718283

BMI1
Polycomb complex protein BMI-1

1

6

High-throughput

0.445

High

430368

PROF1
Profilin-1

1

5

Small-scale

0.437

High

1066831

KIF14
Kinesin-like protein KIF14

1

9

High-throughput

0.437

High

1350494

HECW2
E3 ubiquitin-protein ligase HECW2

1

3

High-throughput

0.437

High

1312307

MED10
Mediator of RNA polymerase II transcription subunit 10

1

0

High-throughput

0.426

High

600996

MK
Midkine

2

0

High-throughput

0.328

High

773148

PBX2
Pre-B-cell leukemia transcription factor 2

2

0

High-throughput

0.328

High

1139188

RSBN1
Lysine-specific demethylase 9

2

0

High-throughput

0.328

High

1051205

BTG3
Protein BTG3

1

0

High-throughput

0.282

High

61491

CNOT1
CCR4-NOT transcription complex subunit 1

1

0

High-throughput

0.279

Low

1331039

SMOC1
SPARC-related modular calcium-binding protein 1

1

0

High-throughput

0.279

Low

489631

OSTP
Osteopontin

1

0

Small-scale

0.251

Low

1215850

INLR1
Interferon lambda receptor 1

1

0

Small-scale

0.249

Low

483731

CT456
Cancer/testis antigen family 45 member A6

1

0

High-throughput

0.232

Low


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Last updated: 15 Jul 2024