HitPredict

Interactor 1: A4 (P05067)
Amyloid-beta precursor protein (APP) (ABPP) (APPI) (Alzheimer disease amyloid A4 protein homolog) (Alzheimer disease amyloid protein) (Amyloid precursor protein) (Amyloid-beta (A4) precursor protein) (Amyloid-beta A4 protein) (Cerebral vascular amyloid peptide) (CVAP) (PreA4) (Protease nexin-II) (PN-II) [Cleaved into: N-APP; Soluble APP-alpha (S-APP-alpha); Soluble APP-beta (S-APP-beta); C99 (Beta-secretase C-terminal fragment) (Beta-CTF); Amyloid-beta protein 42 (Abeta42) (Beta-APP42); Amyloid-beta protein 40 (Abeta40) (Beta-APP40); C83 (Alpha-secretase C-terminal fragment) (Alpha-CTF); P3(42); P3(40); C80; Gamma-secretase C-terminal fragment 59 (Amyloid intracellular domain 59) (AICD-59) (AID(59)) (Gamma-CTF(59)); Gamma-secretase C-terminal fragment 57 (Amyloid intracellular domain 57) (AICD-57) (AID(57)) (Gamma-CTF(57)); Gamma-secretase C-terminal fragment 50 (Amyloid intracellular domain 50) (AICD-50) (AID(50)) (Gamma-CTF(50)); C31]
Gene: APP

Interactor 2: TAF1 (P21675)
Transcription initiation factor TFIID subunit 1 (EC 2.3.1.48) (EC 2.7.11.1) (Cell cycle gene 1 protein) (TBP-associated factor 250 kDa) (p250) (Transcription initiation factor TFIID 250 kDa subunit) (TAF(II)250) (TAFII-250) (TAFII250)
Gene: TAF1

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.61	0.60	0.608

Property	Details
Experiments	35914814, unassigned1973
Identification Methods	two hybrid, two hybrid fragment pooling approach
Interaction Type	direct interaction, physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0006468 - protein phosphorylation GO:0010629 - negative regulation of gene expression GO:0045944 - positive regulation of transcription by RNA polymerase II
Homologous interactions	6

Homologous interactions

Color coding for hit scores

	1 770 Hs			1 1893
+	Hs
		395370 A4_HUMAN (19-770): 0: 999: 100.00		CBP_HUMAN (954-1707): 2.54e-87: 320: 11.69
+	Hs
		395067 A4_HUMAN (19-770): 0: 999: 100.00		PB1_HUMAN (1363-1685): 4.04e-51: 201: 18.26
+	Hs
		319104 A4_HUMAN (19-770): 0: 999: 100.00		BRD1_HUMAN (1298-1540): 5.79e-31: 135: 17.48
+	Hs
		394735 A4_HUMAN (19-770): 0: 999: 100.00		BRD3_HUMAN (1394-1559): 3.22e-24: 112: 18.34
+	Hs
		395879 A4_HUMAN (19-770): 0: 999: 100.00		BRWD1_HUMAN (1421-1815): 5.96e-15: 83.6: 11.58
+	Hs
		518057 CO6A3_HUMAN (251-348): 1.13e-23: 110: 28.57		TRI33_HUMAN (1113-1671): 3.28e-64: 242: 12.83