HitPredict

Interactor 1: A4 (P05067)
Amyloid-beta precursor protein (APP) (ABPP) (APPI) (Alzheimer disease amyloid A4 protein homolog) (Alzheimer disease amyloid protein) (Amyloid precursor protein) (Amyloid-beta (A4) precursor protein) (Amyloid-beta A4 protein) (Cerebral vascular amyloid peptide) (CVAP) (PreA4) (Protease nexin-II) (PN-II) [Cleaved into: N-APP; Soluble APP-alpha (S-APP-alpha); Soluble APP-beta (S-APP-beta); C99 (Beta-secretase C-terminal fragment) (Beta-CTF); Amyloid-beta protein 42 (Abeta42) (Beta-APP42); Amyloid-beta protein 40 (Abeta40) (Beta-APP40); C83 (Alpha-secretase C-terminal fragment) (Alpha-CTF); P3(42); P3(40); C80; Gamma-secretase C-terminal fragment 59 (Amyloid intracellular domain 59) (AICD-59) (AID(59)) (Gamma-CTF(59)); Gamma-secretase C-terminal fragment 57 (Amyloid intracellular domain 57) (AICD-57) (AID(57)) (Gamma-CTF(57)); Gamma-secretase C-terminal fragment 50 (Amyloid intracellular domain 50) (AICD-50) (AID(50)) (Gamma-CTF(50)); C31]
Gene: APP

Interactor 2: MP2K4 (P45985)
Dual specificity mitogen-activated protein kinase kinase 4 (MAP kinase kinase 4) (MAPKK 4) (EC 2.7.12.2) (JNK-activating kinase 1) (MAPK/ERK kinase 4) (MEK 4) (SAPK/ERK kinase 1) (SEK1) (Stress-activated protein kinase kinase 1) (SAPK kinase 1) (SAPKK-1) (SAPKK1) (c-Jun N-terminal kinase kinase 1) (JNKK)
Gene: MAP2K4

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.41	0.60	0.501

Property	Details
Experiments	21832049
Identification Methods	pull down
Interaction Type	direct interaction

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0001934 - positive regulation of protein phosphorylation GO:0005829 - cytosol GO:0030424 - axon GO:0043204 - perikaryon GO:0046330 - positive regulation of JNK cascade
Homologous interactions	12

Homologous interactions

Color coding for hit scores

	1 770 Hs			1 399
+	Hs
		394195 A4_HUMAN (19-770): 0: 999: 100.00		AKT2_HUMAN (57-399): 3.9e-126: 374: 20.86
+	Hs
		394194 A4_HUMAN (19-770): 0: 999: 100.00		AKT1_HUMAN (74-399): 9.1e-126: 373: 19.22
+	Hs
		394562 A4_HUMAN (19-770): 0: 999: 100.00		KPCE_HUMAN (3-398): 4.27e-122: 372: 18.23
+	Hs
		394075 A4_HUMAN (19-770): 0: 999: 100.00		KAPCA_HUMAN (91-399): 1.73e-121: 357: 18.41
+	Hs
		394126 A4_HUMAN (19-770): 0: 999: 100.00		KAPCB_HUMAN (92-399): 1.55e-121: 357: 19.43
+	Hs
		394304 A4_HUMAN (19-770): 0: 999: 100.00		MP2K3_HUMAN (22-387): 5.5e-121: 356: 46.72
+	Hs
		394376 A4_HUMAN (19-770): 0: 999: 100.00		MP2K6_HUMAN (69-386): 1.73e-121: 356: 54.72
+	Hs
		394700 A4_HUMAN (19-770): 0: 999: 100.00		KCC1A_HUMAN (99-387): 1.88e-112: 335: 21.92
+	Hs
		394643 A4_HUMAN (19-770): 0: 999: 100.00		PAK1_HUMAN (19-368): 1.08e-99: 308: 28.06
+	Hs
		395965 A4_HUMAN (19-770): 0: 999: 100.00		STK26_HUMAN (98-388): 2.17e-98: 301: 32.88
+	Hs
		131543 A4_HUMAN (19-770): 0: 999: 100.00		STK25_HUMAN (85-387): 5.86e-98: 300: 32.46
+	Hs
		394230 A4_HUMAN (19-770): 0: 999: 100.00		MP2K2_HUMAN (100-393): 3.95e-62: 206: 37.24