Protein: KCC2
Calcium/calmodulin-dependent protein kinase II (EC 2.7.11.17)

Gene: KCC2, CMK2
Organism: Saccharomyces cerevisiae S288C
Interactions: 209
UniProt ID: P22517

Gene Ontology (top 5):
GO:0004672 - protein kinase activity
GO:0004683 - calcium/calmodulin-dependent protein kinase activity
GO:0005516 - calmodulin binding
GO:0005524 - ATP binding
GO:0005737 - cytoplasm

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

449068

CALM
Calmodulin

6

20

Small-scale

0.950

High

649598

EDE1
EH domain-containing and endocytosis protein 1

2

1

High-throughput

0.776

High

578869

HSC82
ATP-dependent molecular chaperone HSC82

2

15

High-throughput

0.754

High

437880

KAPC
cAMP-dependent protein kinase type 3

1

6

High-throughput

0.647

High

441329

KAPB
cAMP-dependent protein kinase type 2

1

6

High-throughput

0.647

High

464554

PBS2
MAP kinase kinase PBS2

1

15

High-throughput

0.647

High

585856

CSK21
Casein kinase II subunit alpha

1

15

High-throughput

0.647

High

599325

FUS3
Mitogen-activated protein kinase FUS3

1

18

High-throughput

0.647

High

602320

PHO85
Cyclin-dependent protein kinase PHO85

1

5

High-throughput

0.647

High

649562

STE11
Serine/threonine-protein kinase STE11

1

5

High-throughput

0.647

High

649582

KNS1
Dual specificity protein kinase KNS1

1

11

High-throughput

0.647

High

649686

YGK3
Glycogen synthase kinase-3 homolog YGK3

1

11

High-throughput

0.647

High

649687

PKH2
Serine/threonine-protein kinase PKH2

1

16

High-throughput

0.647

High

523090

HSP71
Heat shock protein SSA1

3

5

High-throughput

0.624

High

649584

HOG1
Mitogen-activated protein kinase HOG1

1

18

Small-scale

0.621

High

392250

HSP82
ATP-dependent molecular chaperone HSP82

1

15

High-throughput

0.618

High

436322

RS31
Ubiquitin-ribosomal protein eS31 fusion protein [Cleaved into: Ubiquitin; Small ribosomal subunit protein eS31

1

9

High-throughput

0.618

High

628039

FKBP
FK506-binding protein 1

1

3

High-throughput

0.618

High

649590

GSP1
GTP-binding nuclear protein GSP1/CNR1

1

1

High-throughput

0.618

High

649643

CLA4
Serine/threonine-protein kinase CLA4

1

3

High-throughput

0.618

High

649608

OPY1
Pleckstrin homology domain protein OPY1

1

0

High-throughput

0.614

High

649570

SYP1
Suppressor of yeast profilin deletion

2

1

High-throughput

0.601

High

649560

KCC2
Calcium/calmodulin-dependent protein kinase II

1

18

High-throughput

0.590

High

649573

NSR1
Nuclear localization sequence-binding protein

1

2

High-throughput

0.579

High

649614

AKR1
Palmitoyltransferase AKR1

1

2

High-throughput

0.579

High

649684

CMR3
Zinc finger protein CRM3

1

1

High-throughput

0.579

High

543850

SSB1
Ribosome-associated molecular chaperone SSB1

2

5

High-throughput

0.571

High

649664

RLI1
Translation initiation factor RLI1

1

0

Small-scale

0.560

High

649577

XPO1
Exportin-1

1

8

High-throughput

0.536

High

632230

RPAB2
DNA-directed RNA polymerases I, II, and III subunit RPABC2

1

1

High-throughput

0.501

High

649565

DBR1
Lariat debranching enzyme

1

1

High-throughput

0.501

High

649585

PAH1
Phosphatidic acid phosphohydrolase 1

1

1

High-throughput

0.501

High

649589

GLRX4
Monothiol glutaredoxin-4

1

5

High-throughput

0.501

High

649616

TCPD
T-complex protein 1 subunit delta

1

1

High-throughput

0.501

High

649623

VFA1
VPS4-associated protein 1

1

1

High-throughput

0.501

High

649632

GPP1
Glycerol-1-phosphate phosphohydrolase 1

1

1

High-throughput

0.501

High

649641

LSM1
LSM1-LSM7 complex subunit LSM1

1

2

High-throughput

0.501

High

649645

MSN5
Protein MSN5

1

5

High-throughput

0.501

High

649646

PDK2
[Pyruvate dehydrogenase

1

2

High-throughput

0.501

High

649650

TBG
Tubulin gamma chain

1

6

High-throughput

0.501

High

649670

ASND1
Asparagine synthetase domain-containing protein YML096W

1

1

High-throughput

0.501

High

649599

MRP8
Uncharacterized protein MRP8

1

0

High-throughput

0.480

High

649606

YBS1
Uncharacterized protein YBR071W

1

0

High-throughput

0.480

High

649607

RFC5
Replication factor C subunit 5

1

0

High-throughput

0.480

High

649612

GRE3
NADPH-dependent aldose reductase GRE3

1

0

High-throughput

0.480

High

649620

VHR2
Transcription factor VHR2

1

0

High-throughput

0.480

High

649637

TDA10
Probable ATP-dependent kinase TDA10

1

0

High-throughput

0.480

High

649682

DSE3
Protein DSE3

1

0

High-throughput

0.480

High

649683

ATG29
Autophagy-related protein 29

1

0

High-throughput

0.480

High

149592

RS9A
Small ribosomal subunit protein uS4A

1

1

High-throughput

0.479

High

368869

SYMC
Methionine--tRNA ligase, cytoplasmic

1

4

High-throughput

0.479

High

432490

RL7A
Large ribosomal subunit protein uL30A

1

3

High-throughput

0.479

High

433147

RL17A
Large ribosomal subunit protein uL22A

1

2

High-throughput

0.479

High

438802

CYSD
Homocysteine/cysteine synthase

1

3

High-throughput

0.479

High

450523

FAS1
Fatty acid synthase subunit beta

1

2

High-throughput

0.479

High

514464

RS18A
Small ribosomal subunit protein uS13A

1

1

High-throughput

0.479

High

518208

IF4A
ATP-dependent RNA helicase eIF4A

1

1

High-throughput

0.479

High

536077

ARF1
ADP-ribosylation factor 1

1

1

High-throughput

0.479

High

553944

TCPA
T-complex protein 1 subunit alpha

1

1

High-throughput

0.479

High

557560

NAT1
N-terminal acetyltransferase A complex subunit NAT1

1

5

High-throughput

0.479

High

572516

ALF
Fructose-bisphosphate aldolase

1

1

High-throughput

0.479

High

598955

PFKA2
ATP-dependent 6-phosphofructokinase subunit beta

1

1

High-throughput

0.479

High

645680

HSP74
Heat shock protein SSA4

1

5

High-throughput

0.479

High

649468

UBA1
Ubiquitin-activating enzyme E1 1

1

2

High-throughput

0.479

High

649561

TRX2
Thioredoxin-2

1

2

High-throughput

0.479

High

649571

CDC48
Cell division control protein 48

1

2

High-throughput

0.479

High

649575

BMH1
Protein BMH1

1

10

High-throughput

0.479

High

649578

HS104
Heat shock protein 104

1

1

High-throughput

0.479

High

649580

IMB3
Importin subunit beta-3

1

4

High-throughput

0.479

High

649586

CBS
Cystathionine beta-synthase

1

1

High-throughput

0.479

High

649587

HSP7F
Heat shock protein homolog SSE1

1

9

High-throughput

0.479

High

649588

HSP79
Heat shock protein homolog SSE2

1

10

High-throughput

0.479

High

649592

UFD4
Ubiquitin fusion degradation protein 4

1

6

High-throughput

0.479

High

649593

PRS6B
26S proteasome regulatory subunit 6B homolog

1

3

High-throughput

0.479

High

649595

PGM1
Phosphoglucomutase 1

1

1

High-throughput

0.479

High

649600

EF1G2
Elongation factor 1-gamma 2

1

3

High-throughput

0.479

High

649605

ATG8
Autophagy-related protein 8

1

1

High-throughput

0.479

High

649610

SDS24
Protein SDS24

1

4

High-throughput

0.479

High

649613

SDO1L
Restriction of telomere capping protein 3

1

1

Small-scale

0.479

High

649639

SYEC
Glutamate--tRNA ligase, cytoplasmic

1

2

High-throughput

0.479

High

649644

RIR4
Ribonucleoside-diphosphate reductase small chain 2

1

1

High-throughput

0.479

High

649651

HST2
NAD-dependent protein deacetylase HST2

1

1

High-throughput

0.479

High

649653

GIS2
Zinc finger protein GIS2

1

1

High-throughput

0.479

High

649655

ARG56
Protein ARG5,6, mitochondrial [Cleaved into: N-acetyl-gamma-glutamyl-phosphate reductase

1

2

High-throughput

0.479

High

649656

UBP2
Ubiquitin carboxyl-terminal hydrolase 2

1

2

High-throughput

0.479

High

649657

ACS1
Acetyl-coenzyme A synthetase 1

1

1

High-throughput

0.479

High

365563

PGK
Phosphoglycerate kinase

1

0

High-throughput

0.458

High

383263

RL28
Large ribosomal subunit protein uL15

1

0

High-throughput

0.458

High

417028

VDAC1
Non-selective voltage-gated ion channel 1

1

0

High-throughput

0.458

High

427139

RLA0
Large ribosomal subunit protein uL10

1

0

High-throughput

0.458

High

434838

RS3
Small ribosomal subunit protein uS3

1

0

High-throughput

0.458

High

452478

PUR2
Bifunctional purine biosynthetic protein ADE5,7 [Includes: Phosphoribosylamine--glycine ligase

1

0

High-throughput

0.458

High

452562

C1TC
C-1-tetrahydrofolate synthase, cytoplasmic

1

0

High-throughput

0.458

High

576939

AMPL
Vacuolar aminopeptidase 1

1

0

High-throughput

0.458

High

585682

UBC4
Ubiquitin-conjugating enzyme E2 4

1

0

High-throughput

0.458

High

605284

CAP
Adenylyl cyclase-associated protein

1

0

High-throughput

0.458

High

649566

DBP2
ATP-dependent RNA helicase DBP2

1

0

High-throughput

0.458

High

649567

NAP1
Nucleosome assembly protein

1

0

High-throughput

0.458

High

649568

RS2
Small ribosomal subunit protein uS5

1

0

High-throughput

0.458

High

649601

NDK
Nucleoside diphosphate kinase

1

0

High-throughput

0.458

High

649603

AAP1
Alanine/arginine aminopeptidase

1

0

High-throughput

0.458

High

649604

RL32
Large ribosomal subunit protein eL32

1

0

High-throughput

0.458

High

649609

AIM4
Altered inheritance of mitochondria protein 4

1

0

High-throughput

0.458

High

649615

STM1
Suppressor protein STM1

1

0

High-throughput

0.458

High

649633

RL10
Large ribosomal subunit protein uL16

1

0

High-throughput

0.458

High

649648

PIL1
Sphingolipid long chain base-responsive protein PIL1

1

0

High-throughput

0.458

High

649652

FOL1
Folic acid synthesis protein FOL1 [Includes: Dihydroneopterin aldolase

1

0

High-throughput

0.458

High

649654

ALDH3
Aldehyde dehydrogenase [NAD(P)+] 2

1

0

High-throughput

0.458

High

649658

RS15
Small ribosomal subunit protein uS19

1

0

High-throughput

0.458

High

649673

SYRC
Arginine--tRNA ligase, cytoplasmic

1

0

High-throughput

0.458

High

649679

TSR1
Ribosome biogenesis protein TSR1

1

0

High-throughput

0.458

High

649680

YPD1
Phosphorelay intermediate protein YPD1

1

0

High-throughput

0.458

High

454649

RAD2
DNA repair protein RAD2

1

1

High-throughput

0.457

High

534047

HSF
Heat shock transcription factor

1

2

Small-scale

0.457

High

603597

ERS1
Cystine transporter

1

1

High-throughput

0.457

High

642002

DPOE
DNA polymerase epsilon catalytic subunit A

1

1

Small-scale

0.457

High

644654

MAG
DNA-3-methyladenine glycosylase

1

1

High-throughput

0.457

High

649618

OXA1
Mitochondrial inner membrane protein OXA1

1

1

High-throughput

0.457

High

649622

AVT6
Vacuolar amino acid transporter 6

1

8

High-throughput

0.457

High

649634

VATH
V-type proton ATPase subunit H

1

1

High-throughput

0.457

High

649640

RL17B
Large ribosomal subunit protein uL22B

1

2

High-throughput

0.457

High

649662

SPP1
COMPASS component SPP1

1

3

High-throughput

0.457

High

649663

PIR1
Cell wall mannoprotein PIR1

1

1

High-throughput

0.457

High

649675

JIP5
WD repeat-containing protein JIP5

1

1

High-throughput

0.457

High

649677

CDA1
Chitin deacetylase 1

1

1

High-throughput

0.457

High

649681

SGT1
Protein SGT1

1

5

High-throughput

0.457

High

394247

EF1A
Elongation factor 1-alpha

1

1

High-throughput

0.445

High

432976

RL6B
Large ribosomal subunit protein eL6B

1

2

High-throughput

0.437

High

433455

RL26A
Large ribosomal subunit protein uL24A

1

1

High-throughput

0.437

High

435514

RS9B
Small ribosomal subunit protein uS4B

1

1

High-throughput

0.437

High

454612

PROF
Profilin

1

2

High-throughput

0.437

High

503356

RL11A
Large ribosomal subunit protein uL5A

1

1

High-throughput

0.437

High

503751

RL27A
Large ribosomal subunit protein eL27A

1

1

High-throughput

0.437

High

613523

ADT2
ADP,ATP carrier protein 2

1

1

High-throughput

0.437

High

636270

ACO1
Acyl-CoA desaturase 1

1

1

High-throughput

0.437

High

644714

CLH
Clathrin heavy chain

1

1

High-throughput

0.437

High

649574

TF2B
Transcription initiation factor IIB

1

1

High-throughput

0.437

High

649576

RF1M
Peptide chain release factor 1, mitochondrial

1

1

High-throughput

0.437

High

649579

TPS2
Trehalose-phosphatase

1

1

High-throughput

0.437

High

649594

CSE1
Importin alpha re-exporter

1

4

High-throughput

0.437

High

649597

GCN1
eIF-2-alpha kinase activator GCN1

1

7

High-throughput

0.437

High

649617

RS26A
Small ribosomal subunit protein eS26A

1

1

High-throughput

0.437

High

649621

ICP55
Intermediate cleaving peptidase 55

1

1

High-throughput

0.437

High

649627

MMF1
Protein MMF1, mitochondrial

1

1

High-throughput

0.437

High

649629

QDR2
Quinidine resistance protein 2

1

3

High-throughput

0.437

High

649630

RL34B
Large ribosomal subunit protein eL34B

1

1

High-throughput

0.437

High

649638

RPN11
Ubiquitin carboxyl-terminal hydrolase RPN11

1

2

High-throughput

0.437

High

649647

RL26B
Large ribosomal subunit protein uL24B

1

1

High-throughput

0.437

High

649659

RL6A
Large ribosomal subunit protein eL6A

1

2

High-throughput

0.437

High

649676

URN1
Pre-mRNA-splicing factor URN1

1

1

High-throughput

0.437

High

649678

SYT1
Arf guanine nucleotide exchange factor SYT1

1

1

High-throughput

0.437

High

367896

ENO2
Enolase 2

1

1

High-throughput

0.407

High

361471

SODM
Superoxide dismutase [Mn], mitochondrial

2

0

High-throughput

0.310

High

649569

MRC1
Mediator of replication checkpoint protein 1

1

0

High-throughput

0.261

Low

649583

RM49
Large ribosomal subunit protein mL61

1

0

High-throughput

0.261

Low

649611

YB70
Uncharacterized membrane protein YBR220C

1

0

High-throughput

0.261

Low

649626

PP4R3
Serine/threonine-protein phosphatase 4 regulatory subunit 3

1

0

High-throughput

0.261

Low

649642

NET1
Nucleolar protein NET1

1

0

High-throughput

0.261

Low

649665

YMD7
Uncharacterized protein YML037C

1

0

High-throughput

0.261

Low

649666

NUP53
Nucleoporin NUP53

1

0

High-throughput

0.261

Low

649667

RIM13
Calpain-like protease 1

1

0

High-throughput

0.261

Low

649669

SYF1
Pre-mRNA-splicing factor SYF1

1

0

High-throughput

0.261

Low

649671

TVP18
Golgi apparatus membrane protein TVP18

1

0

High-throughput

0.261

Low

649674

ARPC3
Actin-related protein 2/3 complex subunit 3

1

0

High-throughput

0.261

Low

150260

RPN13
26S proteasome regulatory subunit RPN13

1

0

High-throughput

0.249

Low

268867

MRP10
Small ribosomal subunit protein mS37

1

0

High-throughput

0.249

Low

427539

RLA1
Large ribosomal subunit protein P1A

1

0

High-throughput

0.249

Low

432800

RL9A
Large ribosomal subunit protein uL6A

1

0

High-throughput

0.249

Low

433970

RL33A
Large ribosomal subunit protein eL33A

1

0

High-throughput

0.249

Low

441713

RS14A
Small ribosomal subunit protein uS11A

1

0

High-throughput

0.249

Low

454277

CARP
Saccharopepsin

1

0

High-throughput

0.249

Low

454884

RS19A
Small ribosomal subunit protein eS19A

1

0

High-throughput

0.249

Low

502628

RS25B
Small ribosomal subunit protein eS25B

1

0

High-throughput

0.249

Low

503467

RS28B
Small ribosomal subunit protein eS28B

1

0

High-throughput

0.249

Low

511138

RL20B
Large ribosomal subunit protein eL20B

1

0

High-throughput

0.249

Low

511373

RL43B
Large ribosomal subunit protein eL43B

1

0

High-throughput

0.249

Low

511628

RS23B
Small ribosomal subunit protein uS12B

1

0

High-throughput

0.249

Low

511732

RS24A
Small ribosomal subunit protein eS24A

1

0

High-throughput

0.249

Low

511903

RS30A
Small ribosomal subunit protein eS30A

1

0

High-throughput

0.249

Low

513631

RL2A
Large ribosomal subunit protein uL2A

1

0

High-throughput

0.249

Low

513817

RS11B
Small ribosomal subunit protein uS17B

1

0

High-throughput

0.249

Low

514096

RS16B
Small ribosomal subunit protein uS9B

1

0

High-throughput

0.249

Low

514229

RL12B
Large ribosomal subunit protein uL11B

1

0

High-throughput

0.249

Low

515043

RL19B
Large ribosomal subunit protein eL19

1

0

High-throughput

0.249

Low

515209

RL35A
Large ribosomal subunit protein uL29A

1

0

High-throughput

0.249

Low

550626

SIR4
Regulatory protein SIR4

1

0

High-throughput

0.249

Low

618547

FAS2
Fatty acid synthase subunit alpha

1

0

High-throughput

0.249

Low

649563

MPCP
Mitochondrial phosphate carrier protein

1

0

High-throughput

0.249

Low

649564

RL24B
Large ribosomal subunit protein eL24B

1

0

High-throughput

0.249

Low

649572

RL16B
Large ribosomal subunit protein uL13B

1

0

High-throughput

0.249

Low

649581

NDI1
Rotenone-insensitive NADH-ubiquinone oxidoreductase, mitochondrial

1

0

High-throughput

0.249

Low

649591

RSSA1
Small ribosomal subunit protein uS2A

1

0

High-throughput

0.249

Low

649596

RS3A1
Small ribosomal subunit protein eS1A

1

0

High-throughput

0.249

Low

649602

RL14A
Large ribosomal subunit protein eL14A

1

0

High-throughput

0.249

Low

649619

SNU13
13 kDa ribonucleoprotein-associated protein

1

0

High-throughput

0.249

Low

649624

IES2
Ino eighty subunit 2

1

0

High-throughput

0.249

Low

649625

YNU8
Uncharacterized protein YNL208W

1

0

High-throughput

0.249

Low

649628

RL13B
Large ribosomal subunit protein eL13B

1

0

High-throughput

0.249

Low

649631

RS29B
Small ribosomal subunit protein uS14B

1

0

High-throughput

0.249

Low

649635

COPB
Coatomer subunit beta

1

0

High-throughput

0.249

Low

649636

SPR3
Sporulation-regulated protein 3

1

0

High-throughput

0.249

Low

649649

SDA1
Protein SDA1

1

0

High-throughput

0.249

Low

649660

RNT1
Ribonuclease 3

1

0

High-throughput

0.249

Low

649661

RL21A
Large ribosomal subunit protein eL21A

1

0

High-throughput

0.249

Low

649668

SCC2
Sister chromatid cohesion protein 2

1

0

High-throughput

0.249

Low

649672

BCH1
Protein BCH1

1

0

High-throughput

0.249

Low

649685

RRG1
Required for respiratory growth protein 1, mitochondrial

1

0

High-throughput

0.249

Low

649688

NCA2
Nuclear control of ATPase protein 2

1

0

High-throughput

0.249

Low


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Last updated: 11Aug2025