HitPredict

Interactor 1: A4 (P05067)
Amyloid-beta precursor protein (APP) (ABPP) (APPI) (Alzheimer disease amyloid A4 protein homolog) (Alzheimer disease amyloid protein) (Amyloid precursor protein) (Amyloid-beta (A4) precursor protein) (Amyloid-beta A4 protein) (Cerebral vascular amyloid peptide) (CVAP) (PreA4) (Protease nexin-II) (PN-II) [Cleaved into: N-APP; Soluble APP-alpha (S-APP-alpha); Soluble APP-beta (S-APP-beta); C99 (Beta-secretase C-terminal fragment) (Beta-CTF); Amyloid-beta protein 42 (Abeta42) (Beta-APP42); Amyloid-beta protein 40 (Abeta40) (Beta-APP40); C83 (Alpha-secretase C-terminal fragment) (Alpha-CTF); P3(42); P3(40); C80; Gamma-secretase C-terminal fragment 59 (Amyloid intracellular domain 59) (AICD-59) (AID(59)) (Gamma-CTF(59)); Gamma-secretase C-terminal fragment 57 (Amyloid intracellular domain 57) (AICD-57) (AID(57)) (Gamma-CTF(57)); Gamma-secretase C-terminal fragment 50 (Amyloid intracellular domain 50) (AICD-50) (AID(50)) (Gamma-CTF(50)); C31]
Gene: APP

Interactor 2: SRPK2 (P78362)
SRSF protein kinase 2 (EC 2.7.11.1) (SFRS protein kinase 2) (Serine/arginine-rich protein-specific kinase 2) (SR-protein-specific kinase 2) [Cleaved into: SRSF protein kinase 2 N-terminal; SRSF protein kinase 2 C-terminal]
Gene: SRPK2

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.72	0.60	0.658

Property	Details
Experiments	35914814, 21832049, unassigned1973
Identification Methods	two hybrid, pull down, two hybrid fragment pooling approach
Interaction Type	direct interaction, physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005737 - cytoplasm GO:0005829 - cytosol GO:0006468 - protein phosphorylation GO:0010628 - positive regulation of gene expression
Homologous interactions	7

Homologous interactions

Color coding for hit scores

	1 770 Hs			1 688
+	Hs
		395549 A4_HUMAN (19-770): 0: 999: 100.00		SRPK1_HUMAN (27-688): 1.57e-125: 388: 53.22
+	Hs
		394544 A4_HUMAN (19-770): 0: 999: 100.00		CDK3_HUMAN (378-688): 7.03e-93: 292: 17.41
+	Hs
		394747 A4_HUMAN (19-770): 0: 999: 100.00		KS6A2_HUMAN (2-372): 3.86e-77: 263: 15.21
+	Hs
		396020 A4_HUMAN (19-770): 0: 999: 100.00		KS6A6_HUMAN (2-362): 5.53e-77: 263: 15.92
+	Hs
		270362 A4_HUMAN (19-770): 0: 999: 100.00		KS6A5_HUMAN (3-343): 1.04e-72: 252: 14.52
+	Hs
		395359 A4_HUMAN (19-770): 0: 999: 100.00		DYRK2_HUMAN (51-234): 1.48e-62: 221: 29.35
+	Hs
		394341 A4_HUMAN (19-770): 0: 999: 100.00		CLK3_HUMAN (62-240): 6.66e-62: 220: 31.11