Protein: PFKAP
ATP-dependent 6-phosphofructokinase, platelet type (ATP-PFK) (PFK-P) (EC 2.7.1.11) (6-phosphofructokinase type C) (Phosphofructo-1-kinase isozyme C) (PFK-C) (Phosphohexokinase)

Gene: PFKAP, PFKP
Organism: Homo sapiens
Interactions: 219
UniProt ID: Q01813

Gene Ontology (top 5):
GO:0003872 - 6-phosphofructokinase activity
GO:0005524 - ATP binding
GO:0005634 - nucleus
GO:0005737 - cytoplasm
GO:0005829 - cytosol

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

437738

PFKAM
ATP-dependent 6-phosphofructokinase, muscle type

5

13

Small-scale

0.916

High

571705

PFKAL
ATP-dependent 6-phosphofructokinase, liver type

3

13

High-throughput

0.861

High

966682

PFKAP
ATP-dependent 6-phosphofructokinase, platelet type

1

13

Small-scale

0.701

High

338294

EGFR
Epidermal growth factor receptor

3

7

Small-scale

0.664

High

678550

MK04
Mitogen-activated protein kinase 4

2

12

High-throughput

0.628

High

903807

NTF2
Nuclear transport factor 2

2

2

High-throughput

0.606

High

966745

NELL1
Protein kinase C-binding protein NELL1

2

0

High-throughput

0.602

High

496875

TAU
Microtubule-associated protein tau

2

9

High-throughput

0.601

High

384669

NTRK1
High affinity nerve growth factor receptor

2

14

High-throughput

0.594

High

227202

PRKN
E3 ubiquitin-protein ligase parkin

2

9

High-throughput

0.584

High

346557

MYC
Myc proto-oncogene protein

2

4

High-throughput

0.584

High

503919

HSP7C
Heat shock cognate 71 kDa protein

2

2

High-throughput

0.584

High

966683

MECOM
Histone-lysine N-methyltransferase MECOM

2

3

High-throughput

0.584

High

966698

DX39B
Spliceosome RNA helicase DDX39B

2

2

Small-scale

0.584

High

966762

ACE2
Angiotensin-converting enzyme 2

2

2

Small-scale

0.584

High

966784

MCM9
DNA helicase MCM9

2

5

Small-scale

0.584

High

681796

AKT1
RAC-alpha serine/threonine-protein kinase

1

2

Small-scale

0.578

High

369429

ESR1
Estrogen receptor

2

3

High-throughput

0.571

High

966722

TBA1A
Tubulin alpha-1A chain

2

2

High-throughput

0.571

High

655319

P85A
Phosphatidylinositol 3-kinase regulatory subunit alpha

1

3

Small-scale

0.561

High

584930

RO52
E3 ubiquitin-protein ligase TRIM21

1

0

Small-scale

0.554

High

966711

LRRK2
Leucine-rich repeat serine/threonine-protein kinase 2

2

2

High-throughput

0.552

High

869612

TERF1
Telomeric repeat-binding factor 1

1

1

High-throughput

0.541

High

966770

WNK1
Serine/threonine-protein kinase WNK1

1

7

High-throughput

0.541

High

966787

AGO2
Protein argonaute-2

1

1

High-throughput

0.541

High

363091

FINC
Fibronectin

1

1

High-throughput

0.536

High

374074

RAF1
RAF proto-oncogene serine/threonine-protein kinase

1

2

High-throughput

0.536

High

646809

1433T
14-3-3 protein theta

1

6

High-throughput

0.536

High

717717

BMI1
Polycomb complex protein BMI-1

1

2

High-throughput

0.536

High

794378

GRK6
G protein-coupled receptor kinase 6

1

5

High-throughput

0.536

High

817935

SOX2
Transcription factor SOX-2

1

2

High-throughput

0.536

High

904452

1433G
14-3-3 protein gamma

1

6

High-throughput

0.536

High

966684

KPCZ
Protein kinase C zeta type

1

3

High-throughput

0.536

High

966691

ILK
Integrin-linked protein kinase

1

3

High-throughput

0.536

High

966695

SNW1
SNW domain-containing protein 1

1

2

High-throughput

0.536

High

966696

CUL3
Cullin-3

1

1

High-throughput

0.536

High

966716

PKN3
Serine/threonine-protein kinase N3

1

3

High-throughput

0.536

High

966736

HIPK4
Homeodomain-interacting protein kinase 4

1

10

High-throughput

0.536

High

966737

WDR19
WD repeat-containing protein 19

1

3

High-throughput

0.536

High

966746

CSN5
COP9 signalosome complex subunit 5

1

2

High-throughput

0.536

High

966756

CDC5L
Cell division cycle 5-like protein

1

2

High-throughput

0.536

High

966764

B2L14
Apoptosis facilitator Bcl-2-like protein 14

1

2

High-throughput

0.536

High

966774

IF122
Intraflagellar transport protein 122 homolog

1

4

High-throughput

0.536

High

966797

WIPI2
WD repeat domain phosphoinositide-interacting protein 2

1

7

High-throughput

0.536

High

966749

ACD
Adrenocortical dysplasia protein homolog

1

0

High-throughput

0.518

High

177869

TMPS2
Transmembrane protease serine 2

1

6

High-throughput

0.515

High

328813

TOP3B
DNA topoisomerase 3-beta-1

1

1

High-throughput

0.515

High

429874

CATL1
Procathepsin L

1

3

High-throughput

0.515

High

431208

CATB
Cathepsin B

1

5

High-throughput

0.515

High

456853

FURIN
Furin

1

1

High-throughput

0.515

High

544958

AMPN
Aminopeptidase N

1

2

High-throughput

0.515

High

617522

CRCM
Colorectal mutant cancer protein

1

1

High-throughput

0.515

High

648728

DPP4
Dipeptidyl peptidase 4

1

1

High-throughput

0.515

High

726157

BASI
Basigin

1

1

High-throughput

0.515

High

779264

CCNF
Cyclin-F

1

2

High-throughput

0.515

High

966686

DMWD
Dystrophia myotonica WD repeat-containing protein

1

5

High-throughput

0.515

High

966724

TM11B
Transmembrane protease serine 11B

1

6

High-throughput

0.515

High

966741

CLC4D
C-type lectin domain family 4 member D

1

3

High-throughput

0.515

High

966781

TMPS4
Transmembrane protease serine 4

1

6

High-throughput

0.515

High

966788

CLC4E
C-type lectin domain family 4 member E

1

3

High-throughput

0.515

High

966726

MTA70
N6-adenosine-methyltransferase catalytic subunit

1

0

High-throughput

0.513

High

902531

SUMO2
Small ubiquitin-related modifier 2

1

4

High-throughput

0.501

High

383748

ERBB2
Receptor tyrosine-protein kinase erbB-2

1

7

High-throughput

0.500

High

411357

INSR
Insulin receptor

1

16

High-throughput

0.500

High

435613

IGF1R
Insulin-like growth factor 1 receptor

1

15

High-throughput

0.500

High

452393

PGFRB
Platelet-derived growth factor receptor beta

1

16

High-throughput

0.500

High

507955

FGFR1
Fibroblast growth factor receptor 1

1

20

High-throughput

0.500

High

601497

FGFR2
Fibroblast growth factor receptor 2

1

19

High-throughput

0.500

High

607944

FGFR4
Fibroblast growth factor receptor 4

1

18

High-throughput

0.500

High

665468

EPHA8
Ephrin type-A receptor 8

1

7

High-throughput

0.500

High

729265

VGFR3
Vascular endothelial growth factor receptor 3

1

11

High-throughput

0.500

High

966685

TYRO3
Tyrosine-protein kinase receptor TYRO3

1

13

High-throughput

0.500

High

966706

NTRK3
NT-3 growth factor receptor

1

14

High-throughput

0.500

High

966715

STYK1
Tyrosine-protein kinase STYK1

1

5

High-throughput

0.500

High

966719

LMTK1
Serine/threonine-protein kinase LMTK1

1

19

High-throughput

0.500

High

966739

SP7
Transcription factor Sp7

1

1

High-throughput

0.500

High

966789

ALK
ALK tyrosine kinase receptor

1

13

High-throughput

0.500

High

966752

FAF2
FAS-associated factor 2

1

1

High-throughput

0.489

High

966747

KAT5
Histone acetyltransferase KAT5

1

0

Small-scale

0.480

High

966761

KLF16
Krueppel-like factor 16

1

0

High-throughput

0.479

High

123572

PGRC1
Membrane-associated progesterone receptor component 1

1

2

Small-scale

0.479

High

148697

CTRO
Citron Rho-interacting kinase

1

5

High-throughput

0.479

High

150952

DVL2
Segment polarity protein dishevelled homolog DVL-2

1

2

High-throughput

0.479

High

155333

NRP1
Neuropilin-1

1

2

High-throughput

0.479

High

244304

BRD4
Bromodomain-containing protein 4

1

3

High-throughput

0.479

High

312056

ZBT7A
Zinc finger and BTB domain-containing protein 7A

1

1

Small-scale

0.479

High

354423

HLAB
HLA class I histocompatibility antigen, B alpha chain

1

1

High-throughput

0.479

High

411677

LCK
Tyrosine-protein kinase Lck

1

3

High-throughput

0.479

High

441484

MET
Hepatocyte growth factor receptor

1

8

High-throughput

0.479

High

475642

UBC
Polyubiquitin-C [Cleaved into: Ubiquitin]

1

8

Small-scale

0.479

High

488684

ARAF
Serine/threonine-protein kinase A-Raf

1

2

High-throughput

0.479

High

525906

IFM1
Interferon-induced transmembrane protein 1

1

3

High-throughput

0.479

High

530628

ITA4
Integrin alpha-4

1

2

High-throughput

0.479

High

552523

RFA2
Replication protein A 32 kDa subunit

1

2

High-throughput

0.479

High

572623

VGFR1
Vascular endothelial growth factor receptor 1

1

11

High-throughput

0.479

High

591307

TNR1B
Tumor necrosis factor receptor superfamily member 1B

1

1

High-throughput

0.479

High

650988

RFA1
Replication protein A 70 kDa DNA-binding subunit

1

2

High-throughput

0.479

High

682167

AKT2
RAC-beta serine/threonine-protein kinase

1

3

Small-scale

0.479

High

749389

BRCA1
Breast cancer type 1 susceptibility protein

1

3

High-throughput

0.479

High

808526

YAP1
Transcriptional coactivator YAP1

1

5

High-throughput

0.479

High

827915

UB2R1
Ubiquitin-conjugating enzyme E2 R1

1

1

High-throughput

0.479

High

832381

MCM2
DNA replication licensing factor MCM2

1

3

High-throughput

0.479

High

850003

UBP11
Ubiquitin carboxyl-terminal hydrolase 11

1

1

High-throughput

0.479

High

852440

RND2
Rho-related GTP-binding protein RhoN

1

8

High-throughput

0.479

High

891092

GBRL2
Gamma-aminobutyric acid receptor-associated protein-like 2

1

2

High-throughput

0.479

High

893912

CDC42
Cell division control protein 42 homolog

1

7

High-throughput

0.479

High

898106

MAX
Protein max

1

4

High-throughput

0.479

High

900389

RHOA
Transforming protein RhoA

1

6

High-throughput

0.479

High

908397

UBE2H
Ubiquitin-conjugating enzyme E2 H

1

2

High-throughput

0.479

High

915615

RHOB
Rho-related GTP-binding protein RhoB

1

6

High-throughput

0.479

High

921531

GBB2
Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2

1

3

High-throughput

0.479

High

922128

RL31
Large ribosomal subunit protein eL31

1

1

High-throughput

0.479

High

925206

RAC1
Ras-related C3 botulinum toxin substrate 1

1

6

High-throughput

0.479

High

926938

1433Z
14-3-3 protein zeta/delta

1

6

High-throughput

0.479

High

966688

UBP4
Ubiquitin carboxyl-terminal hydrolase 4

1

1

High-throughput

0.479

High

966690

TIF1B
Transcription intermediary factor 1-beta

1

2

High-throughput

0.479

High

966693

SQSTM
Sequestosome-1

1

2

High-throughput

0.479

High

966697

DYR1A
Dual specificity tyrosine-phosphorylation-regulated kinase 1A

1

5

High-throughput

0.479

High

966700

CUL7
Cullin-7

1

1

High-throughput

0.479

High

966701

HAPR1
HUWE1-associated protein modifying stress responses 1

1

1

Small-scale

0.479

High

966702

TNIP1
TNFAIP3-interacting protein 1

1

5

High-throughput

0.479

High

966703

U5S1
116 kDa U5 small nuclear ribonucleoprotein component

1

2

High-throughput

0.479

High

966704

RHOH
Rho-related GTP-binding protein RhoH

1

8

High-throughput

0.479

High

966705

EZH2
Histone-lysine N-methyltransferase EZH2

1

2

High-throughput

0.479

High

966708

DUS6
Dual specificity protein phosphatase 6

1

2

High-throughput

0.479

High

966712

RN123
E3 ubiquitin-protein ligase RNF123

1

1

High-throughput

0.479

High

966713

A16L1
Autophagy-related protein 16-1

1

5

High-throughput

0.479

High

966714

VIR
Protein virilizer homolog

1

2

High-throughput

0.479

High

966721

TRI67
Tripartite motif-containing protein 67

1

3

High-throughput

0.479

High

966725

SYVN1
E3 ubiquitin-protein ligase synoviolin

1

3

Small-scale

0.479

High

966728

NAA40
N-alpha-acetyltransferase 40

1

2

High-throughput

0.479

High

966729

RHG24
Rho GTPase-activating protein 24

1

2

High-throughput

0.479

High

966734

KDF1
Keratinocyte differentiation factor 1

1

2

High-throughput

0.479

High

966735

RN149
E3 ubiquitin-protein ligase RNF149

1

2

High-throughput

0.479

High

966738

FBX25
F-box only protein 25

1

1

High-throughput

0.479

High

966740

PARD3
Partitioning defective 3 homolog

1

3

Small-scale

0.479

High

966742

BAP1
Ubiquitin carboxyl-terminal hydrolase BAP1

1

1

High-throughput

0.479

High

966743

ESR2
Estrogen receptor beta

1

3

High-throughput

0.479

High

966744

HDAC2
Histone deacetylase 2

1

6

High-throughput

0.479

High

966748

FBXW7
F-box/WD repeat-containing protein 7

1

2

High-throughput

0.479

High

966751

CHM4C
Charged multivesicular body protein 4c

1

1

High-throughput

0.479

High

966753

RHOV
Rho-related GTP-binding protein RhoV

1

9

High-throughput

0.479

High

966754

CIC
Protein capicua homolog

1

2

High-throughput

0.479

High

966755

RUFY1
RUN and FYVE domain-containing protein 1

1

1

High-throughput

0.479

High

966757

DNJC7
DnaJ homolog subfamily C member 7

1

1

High-throughput

0.479

High

966766

MLP3B
Microtubule-associated proteins 1A/1B light chain 3B

1

2

High-throughput

0.479

High

966767

SPRTN
DNA-dependent metalloprotease SPRTN

1

2

High-throughput

0.479

High

966769

CCDC8
Coiled-coil domain-containing protein 8

1

1

High-throughput

0.479

High

966771

SENP3
Sentrin-specific protease 3

1

1

Small-scale

0.479

High

966772

PKHA4
Pleckstrin homology domain-containing family A member 4

1

5

High-throughput

0.479

High

966773

PRD16
Histone-lysine N-methyltransferase PRDM16

1

3

High-throughput

0.479

High

966775

RHOF
Rho-related GTP-binding protein RhoF

1

8

High-throughput

0.479

High

966776

SHCAF
SIN3-HDAC complex-associated factor

1

1

Small-scale

0.479

High

966777

BRD7
Bromodomain-containing protein 7

1

2

High-throughput

0.479

High

966778

ANLN
Anillin

1

1

High-throughput

0.479

High

966780

FBX6
F-box only protein 6

1

2

High-throughput

0.479

High

966785

HDAC6
Histone deacetylase 6

1

5

Small-scale

0.479

High

966786

TBK1
Serine/threonine-protein kinase TBK1

1

4

High-throughput

0.479

High

966790

AKT3
RAC-gamma serine/threonine-protein kinase

1

2

Small-scale

0.479

High

966795

LOXL2
Lysyl oxidase homolog 2

1

1

High-throughput

0.479

High

966796

TRAF6
TNF receptor-associated factor 6

1

3

High-throughput

0.479

High

771919

VHL
von Hippel-Lindau disease tumor suppressor

1

0

Small-scale

0.460

High

157559

MGST3
Glutathione S-transferase 3, mitochondrial

1

0

High-throughput

0.458

High

179605

RPA34
DNA-directed RNA polymerase I subunit RPA34

1

0

High-throughput

0.458

High

275566

BCAR3
Breast cancer anti-estrogen resistance protein 3

1

0

High-throughput

0.458

High

393167

AT1A1
Sodium/potassium-transporting ATPase subunit alpha-1

1

0

High-throughput

0.458

High

441722

CFAH
Complement factor H

1

0

Small-scale

0.458

High

489005

H14
Histone H1.4

1

0

High-throughput

0.458

High

521257

SKI
Ski oncogene

1

0

Small-scale

0.458

High

521872

CADH1
Cadherin-1

1

0

High-throughput

0.458

High

622434

CCND1
G1/S-specific cyclin-D1

1

0

High-throughput

0.458

High

637856

PSA3
Proteasome subunit alpha type-3

1

0

High-throughput

0.458

High

887812

CD81
CD81 antigen

1

0

High-throughput

0.458

High

912859

ARF6
ADP-ribosylation factor 6

1

0

High-throughput

0.458

High

966689

CACO2
Calcium-binding and coiled-coil domain-containing protein 2

1

0

High-throughput

0.458

High

966692

GAB1
GRB2-associated-binding protein 1

1

0

Small-scale

0.458

High

966694

LAPM5
Lysosomal-associated transmembrane protein 5

1

0

Small-scale

0.458

High

966699

NBR1
Next to BRCA1 gene 1 protein

1

0

High-throughput

0.458

High

966707

CDKN3
Cyclin-dependent kinase inhibitor 3

1

0

High-throughput

0.458

High

966709

CL16A
Protein CLEC16A

1

0

High-throughput

0.458

High

966710

FBX43
F-box only protein 43

1

0

Small-scale

0.458

High

966717

RICTR
Rapamycin-insensitive companion of mTOR

1

0

High-throughput

0.458

High

966720

FGD5
FYVE, RhoGEF and PH domain-containing protein 5

1

0

High-throughput

0.458

High

966723

WAPL
Wings apart-like protein homolog

1

0

High-throughput

0.458

High

966727

DTX2
Probable E3 ubiquitin-protein ligase DTX2

1

0

High-throughput

0.458

High

966730

PLD6
Mitochondrial cardiolipin hydrolase

1

0

High-throughput

0.458

High

966732

CISD2
CDGSH iron-sulfur domain-containing protein 2

1

0

High-throughput

0.458

High

966733

ZBT38
Zinc finger and BTB domain-containing protein 38

1

0

Small-scale

0.458

High

966758

RIOK1
Serine/threonine-protein kinase RIO1

1

0

High-throughput

0.458

High

966760

RN126
E3 ubiquitin-protein ligase RNF126

1

0

High-throughput

0.458

High

966768

TOLIP
Toll-interacting protein

1

0

High-throughput

0.458

High

966779

SIR7
NAD-dependent protein deacetylase sirtuin-7

1

0

High-throughput

0.458

High

966783

PIHD1
PIH1 domain-containing protein 1

1

0

High-throughput

0.458

High

966793

GSTK1
Glutathione S-transferase kappa 1

1

0

High-throughput

0.458

High

966794

AAKB1
5'-AMP-activated protein kinase subunit beta-1

1

0

High-throughput

0.458

High

371403

ANGI
Angiogenin

1

1

High-throughput

0.445

High

528989

CFTR
Cystic fibrosis transmembrane conductance regulator

1

2

High-throughput

0.445

High

581683

VCAM1
Vascular cell adhesion protein 1

1

2

High-throughput

0.445

High

587533

NFKB1
Nuclear factor NF-kappa-B p105 subunit

1

4

High-throughput

0.445

High

966687

SNF5
SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily B member 1

1

1

High-throughput

0.445

High

966731

RYBP
RING1 and YY1-binding protein

1

2

High-throughput

0.445

High

966765

ZDHC5
Palmitoyltransferase ZDHHC5

1

2

High-throughput

0.445

High

966791

ITM2B
Integral membrane protein 2B

1

3

High-throughput

0.445

High

966792

ST38L
Serine/threonine-protein kinase 38-like

1

4

High-throughput

0.445

High

637239

CATS
Cathepsin S

1

3

High-throughput

0.437

High

720257

RFA3
Replication protein A 14 kDa subunit

1

2

High-throughput

0.437

High

965640

IFM3
Interferon-induced transmembrane protein 3

1

3

High-throughput

0.437

High

966750

VP33A
Vacuolar protein sorting-associated protein 33A

1

1

High-throughput

0.437

High

966763

RHBT2
Rho-related BTB domain-containing protein 2

1

9

High-throughput

0.437

High

205282

TGON2
Trans-Golgi network integral membrane protein 2

2

0

High-throughput

0.298

High

966759

TINF2
TERF1-interacting nuclear factor 2

1

0

High-throughput

0.282

High

966782

POTE1
Protection of telomeres protein 1

1

0

High-throughput

0.282

High

259438

NIPS2
Protein NipSnap homolog 2

1

0

High-throughput

0.279

Low

100688

APRIO
Alternative prion protein

1

0

High-throughput

0.249

Low

329649

AGR2
Anterior gradient protein 2 homolog

1

0

High-throughput

0.249

Low

966718

LMBRL
Protein LMBR1L

1

0

High-throughput

0.249

Low

966798

EID1
EP300-interacting inhibitor of differentiation 1

1

0

Small-scale

0.249

Low

1018

SIM26
Small integral membrane protein 26

1

0

High-throughput

0.232

Low


Service provided by Combinatics, Japan

Last updated: 15 Jul 2024