HitPredict

Interactor 1: A4 (P05067)
Amyloid-beta precursor protein (APP) (ABPP) (APPI) (Alzheimer disease amyloid A4 protein homolog) (Alzheimer disease amyloid protein) (Amyloid precursor protein) (Amyloid-beta (A4) precursor protein) (Amyloid-beta A4 protein) (Cerebral vascular amyloid peptide) (CVAP) (PreA4) (Protease nexin-II) (PN-II) [Cleaved into: N-APP; Soluble APP-alpha (S-APP-alpha); Soluble APP-beta (S-APP-beta); C99 (Beta-secretase C-terminal fragment) (Beta-CTF); Amyloid-beta protein 42 (Abeta42) (Beta-APP42); Amyloid-beta protein 40 (Abeta40) (Beta-APP40); C83 (Alpha-secretase C-terminal fragment) (Alpha-CTF); P3(42); P3(40); C80; Gamma-secretase C-terminal fragment 59 (Amyloid intracellular domain 59) (AICD-59) (AID(59)) (Gamma-CTF(59)); Gamma-secretase C-terminal fragment 57 (Amyloid intracellular domain 57) (AICD-57) (AID(57)) (Gamma-CTF(57)); Gamma-secretase C-terminal fragment 50 (Amyloid intracellular domain 50) (AICD-50) (AID(50)) (Gamma-CTF(50)); C31]
Gene: APP

Interactor 2: CLC4D (Q8WXI8)
C-type lectin domain family 4 member D (C-type lectin superfamily member 8) (C-type lectin-like receptor 6) (CLEC-6) (Dendritic cell-associated C-type lectin 3) (DC-associated C-type lectin 3) (Dectin-3) (CD antigen CD368)
Gene: CLEC4D

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.44	0.60	0.515

Property	Details
Experiments	34709727
Identification Methods	affinity chromatography technology, proximity labelling technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005886 - plasma membrane
Homologous interactions	10

Homologous interactions

Color coding for hit scores

	1 770 Hs			1 215
+	Hs
		396040 A4_HUMAN (19-770): 0: 999: 100.00		CLC4E_HUMAN (5-214): 6.42e-59: 186: 35.85
+	Hs
		394060 A4_HUMAN (19-770): 0: 999: 100.00		PGCA_HUMAN (66-212): 5.05e-49: 173: 31.54
+	Hs
		395475 A4_HUMAN (19-770): 0: 999: 100.00		PGCB_HUMAN (56-210): 2.14e-47: 168: 33.76
+	Hs
		394879 A4_HUMAN (19-770): 0: 999: 100.00		COL12_HUMAN (69-214): 1.39e-45: 162: 27.15
+	Hs
		393933 A4_HUMAN (19-770): 0: 999: 100.00		ASGR1_HUMAN (43-208): 1.23e-45: 154: 24.42
+	Hs
		393917 A4_HUMAN (19-770): 0: 999: 100.00		REG1A_HUMAN (68-211): 2.19e-39: 134: 23.49
+	Hs
		987535 APLP2_HUMAN (3-769): 0: 858: 49.17		PGCB_HUMAN (56-210): 2.14e-47: 168: 33.76
+	Hs
		199940 SPIT2_HUMAN (282-399): 1.76e-24: 105: 18.83		CLC4D_HUMAN (1-215): 2.59e-71: 217: 100.00
+	Hs
		199974 SPIT2_HUMAN (282-399): 1.76e-24: 105: 18.83		CLC4E_HUMAN (5-214): 6.42e-59: 186: 35.85
+	Hs
		199475 SPIT1_HUMAN (174-344): 2.57e-17: 88.1: 18.97		CLC7A_HUMAN (9-210): 3.1e-46: 154: 17.89