Protein: SYTM
Threonine--tRNA ligase, mitochondrial (EC 6.1.1.3) (Threonyl-tRNA synthetase) (ThrRS) (Threonyl-tRNA synthetase-like 1)

Gene: SYTM, TARS2
Organism: Homo sapiens
Interactions: 156
UniProt ID: Q9BW92

Gene Ontology (top 5):
GO:0002161 - aminoacyl-tRNA deacylase activity
GO:0004829 - threonine-tRNA ligase activity
GO:0005524 - ATP binding
GO:0005739 - mitochondrion
GO:0005759 - mitochondrial matrix

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

60521

SYTC2
Threonine--tRNA ligase 2, cytoplasmic

2

14

High-throughput

0.783

High

1207127

SYAM
Alanine--tRNA ligase, mitochondrial

1

6

High-throughput

0.618

High

1416020

MTG2
Mitochondrial ribosome-associated GTPase 2

1

2

High-throughput

0.618

High

242794

PRKN
E3 ubiquitin-protein ligase parkin

2

6

High-throughput

0.584

High

279891

CISY
Citrate synthase, mitochondrial

2

2

High-throughput

0.584

High

259084

DNJA2
DnaJ homolog subfamily A member 2

2

3

High-throughput

0.571

High

1162535

CLPP
ATP-dependent Clp protease proteolytic subunit, mitochondrial

2

0

High-throughput

0.559

High

1114186

CUL3
Cullin-3

2

6

High-throughput

0.558

High

1416012

S17A9
Voltage-gated purine nucleotide uniporter SLC17A9

2

2

High-throughput

0.553

High

1416047

FKBP7
Peptidyl-prolyl cis-trans isomerase FKBP7

2

6

High-throughput

0.553

High

1412016

WDR83
WD repeat domain-containing protein 83

2

3

High-throughput

0.549

High

275369

NDUS7
NADH dehydrogenase [ubiquinone] iron-sulfur protein 7, mitochondrial

1

1

High-throughput

0.536

High

288256

KBL
2-amino-3-ketobutyrate coenzyme A ligase, mitochondrial

1

2

High-throughput

0.536

High

564326

CFTR
Cystic fibrosis transmembrane conductance regulator

1

2

High-throughput

0.536

High

690546

KAD4
Adenylate kinase 4, mitochondrial

1

1

High-throughput

0.536

High

869224

UCRI
Cytochrome b-c1 complex subunit Rieske, mitochondrial

1

2

High-throughput

0.536

High

1100642

DHRS2
Dehydrogenase/reductase SDR family member 2, mitochondrial

1

1

High-throughput

0.536

High

1123409

ICT1
Large ribosomal subunit protein mL62

1

2

High-throughput

0.536

High

1310372

HSC20
Iron-sulfur cluster co-chaperone protein HscB

1

4

High-throughput

0.536

High

1326816

CBR4
3-oxoacyl-[acyl-carrier-protein] reductase

1

2

High-throughput

0.536

High

1389188

RT24
Small ribosomal subunit protein uS3m

1

1

High-throughput

0.536

High

1412219

NPS3B
Protein NipSnap homolog 3B

1

2

High-throughput

0.536

High

1416013

LDH6B
L-lactate dehydrogenase A-like 6B

1

2

High-throughput

0.536

High

1416016

GATA
Glutamyl-tRNA(Gln) amidotransferase subunit A, mitochondrial

1

1

High-throughput

0.536

High

1416024

RT30
Large ribosomal subunit protein mL65

1

2

High-throughput

0.536

High

1416033

NPS3A
Protein NipSnap homolog 3A

1

2

High-throughput

0.536

High

1416044

SYYM
Tyrosine--tRNA ligase, mitochondrial

1

2

High-throughput

0.536

High

1416045

RT02
Small ribosomal subunit protein uS2m

1

3

High-throughput

0.536

High

289812

MTU1
Mitochondrial tRNA-specific 2-thiouridylase 1

1

0

High-throughput

0.513

High

1238411

ACSM5
Acyl-coenzyme A synthetase ACSM5, mitochondrial

1

0

High-throughput

0.513

High

1242621

FAHD1
Oxaloacetate tautomerase FAHD1, mitochondrial

1

0

High-throughput

0.513

High

1414062

MYL10
Myosin regulatory light chain 10

1

0

High-throughput

0.513

High

1416010

SCOT2
Succinyl-CoA:3-ketoacid coenzyme A transferase 2, mitochondrial

1

0

High-throughput

0.513

High

1416032

DIC
Mitochondrial dicarboxylate carrier

1

0

High-throughput

0.513

High

1416036

CHRD1
Cysteine and histidine-rich domain-containing protein 1

1

0

High-throughput

0.513

High

1416037

AMACR
Alpha-methylacyl-CoA racemase

1

0

High-throughput

0.513

High

1416042

RT17
Small ribosomal subunit protein uS17m

1

0

High-throughput

0.513

High

182755

GP182
G-protein coupled receptor 182

1

1

High-throughput

0.489

High

337019

AHSA1
Activator of 90 kDa heat shock protein ATPase homolog 1

1

2

High-throughput

0.489

High

520987

HLAC
HLA class I histocompatibility antigen, C alpha chain

1

1

High-throughput

0.489

High

1022113

SHC2
SHC-transforming protein 2

1

2

High-throughput

0.489

High

1090110

KLRB1
Killer cell lectin-like receptor subfamily B member 1

1

1

High-throughput

0.489

High

1291882

P2RY8
S-geranylgeranyl-glutathione receptor P2RY8

1

2

High-throughput

0.489

High

1402408

RSLAB
Ras-like protein family member 10B

1

3

High-throughput

0.489

High

1416017

ADAM7
Disintegrin and metalloproteinase domain-containing protein 7

1

1

High-throughput

0.489

High

1416039

FKBPL
FK506-binding protein-like

1

5

High-throughput

0.489

High

1416043

GPR55
G-protein coupled receptor 55

1

4

High-throughput

0.489

High

183725

RT12
Small ribosomal subunit protein uS12m

1

1

High-throughput

0.479

High

294280

CD123
Translation initiation factor eIF2 assembly protein

1

1

High-throughput

0.479

High

315972

RECQ4
ATP-dependent DNA helicase Q4

1

4

High-throughput

0.479

High

348705

AIFM1
Apoptosis-inducing factor 1, mitochondrial

1

4

High-throughput

0.479

High

363807

EGFR
Epidermal growth factor receptor

1

2

High-throughput

0.479

High

412546

NTRK1
High affinity nerve growth factor receptor

1

4

High-throughput

0.479

High

471221

ODPA
Pyruvate dehydrogenase E1 component subunit alpha, somatic form, mitochondrial

1

2

High-throughput

0.479

High

532918

CH60
60 kDa heat shock protein, mitochondrial

1

4

High-throughput

0.479

High

766814

PHB1
Prohibitin 1

1

2

High-throughput

0.479

High

856365

IF2M
Translation initiation factor IF-2, mitochondrial

1

4

High-throughput

0.479

High

882853

EFTU
Elongation factor Tu, mitochondrial

1

3

High-throughput

0.479

High

883324

UB2R1
Ubiquitin-conjugating enzyme E2 R1

1

3

High-throughput

0.479

High

971020

UBE2H
Ubiquitin-conjugating enzyme E2 H

1

3

High-throughput

0.479

High

1048668

SSBP
Single-stranded DNA-binding protein, mitochondrial

1

1

High-throughput

0.479

High

1090519

TRAP1
Heat shock protein 75 kDa, mitochondrial

1

7

High-throughput

0.479

High

1117826

AUHM
Methylglutaconyl-CoA hydratase, mitochondrial

1

2

High-throughput

0.479

High

1124298

IF4A2
Eukaryotic initiation factor 4A-II

1

2

High-throughput

0.479

High

1142651

PDK1
[Pyruvate dehydrogenase

1

1

High-throughput

0.479

High

1366549

AKAP1
A-kinase anchor protein 1, mitochondrial

1

2

High-throughput

0.479

High

1367174

ESR2
Estrogen receptor beta

1

2

High-throughput

0.479

High

1388258

RRFM
Ribosome-recycling factor, mitochondrial

1

1

High-throughput

0.479

High

1400806

TEFM
Transcription elongation factor, mitochondrial

1

1

High-throughput

0.479

High

1416009

HINT2
Adenosine 5'-monophosphoramidase HINT2

1

2

High-throughput

0.479

High

1416014

AMRA1
Activating molecule in BECN1-regulated autophagy protein 1

1

5

High-throughput

0.479

High

1416019

MTRFR
Mitochondrial translation release factor in rescue

1

4

High-throughput

0.479

High

1416023

MET17
Ribosome assembly protein METTL17, mitochondrial

1

3

High-throughput

0.479

High

1416026

EXD2
Exonuclease 3'-5' domain-containing protein 2

1

3

High-throughput

0.479

High

1416030

MRES1
Mitochondrial transcription rescue factor 1

1

1

High-throughput

0.479

High

1416034

RF1ML
Peptide chain release factor 1-like, mitochondrial

1

4

High-throughput

0.479

High

124474

HAX1
HCLS1-associated protein X-1

1

0

High-throughput

0.458

High

275098

COQ9
Ubiquinone biosynthesis protein COQ9, mitochondrial

1

0

High-throughput

0.458

High

440193

LCK
Tyrosine-protein kinase Lck

1

0

High-throughput

0.458

High

505453

CISD3
CDGSH iron-sulfur domain-containing protein 3, mitochondrial

1

0

High-throughput

0.458

High

560080

COX41
Cytochrome c oxidase subunit 4 isoform 1, mitochondrial

1

0

High-throughput

0.458

High

1359184

MAIP1
m-AAA protease-interacting protein 1, mitochondrial

1

0

High-throughput

0.458

High

1383551

MCUR1
Mitochondrial calcium uniporter regulator 1

1

0

High-throughput

0.458

High

1416027

RMND1
Required for meiotic nuclear division protein 1 homolog

1

0

High-throughput

0.458

High

1122

SIM26
Small integral membrane protein 26

1

1

High-throughput

0.445

High

1135926

FAKD3
FAST kinase domain-containing protein 3, mitochondrial

1

3

Small-scale

0.445

High

1209609

LRRK2
Leucine-rich repeat serine/threonine-protein kinase 2

1

5

High-throughput

0.445

High

1311777

HOMEZ
Homeobox and leucine zipper protein Homez

1

1

High-throughput

0.439

High

326013

UBR5
E3 ubiquitin-protein ligase UBR5

1

6

Small-scale

0.437

High

346273

STAU1
Double-stranded RNA-binding protein Staufen homolog 1

1

1

High-throughput

0.437

High

473040

RU17
U1 small nuclear ribonucleoprotein 70 kDa

1

1

High-throughput

0.437

High

589590

RFA2
Replication protein A 32 kDa subunit

1

3

High-throughput

0.437

High

769070

RFA3
Replication protein A 14 kDa subunit

1

2

High-throughput

0.437

High

831361

CCNF
Cyclin-F

1

4

High-throughput

0.437

High

861756

NEDD4
E3 ubiquitin-protein ligase NEDD4

1

6

Small-scale

0.437

High

1015732

RHOG
Rho-related GTP-binding protein RhoG

1

2

High-throughput

0.437

High

1107166

BIRC3
Baculoviral IAP repeat-containing protein 3

1

2

High-throughput

0.437

High

1249184

LMBRL
Protein LMBR1L

1

2

High-throughput

0.437

High

1255363

TRI67
Tripartite motif-containing protein 67

1

8

High-throughput

0.437

High

1276734

PARPT
Protein mono-ADP-ribosyltransferase TIPARP

1

2

High-throughput

0.437

High

1393658

DDRGK
DDRGK domain-containing protein 1

1

3

High-throughput

0.437

High

1397395

CI072
Guanine nucleotide exchange factor C9orf72

1

2

High-throughput

0.437

High

1405838

DNJC7
DnaJ homolog subfamily C member 7

1

5

High-throughput

0.437

High

1411272

LZTS2
Leucine zipper putative tumor suppressor 2

1

1

High-throughput

0.437

High

1412089

TRI56
E3 ubiquitin-protein ligase TRIM56

1

2

High-throughput

0.437

High

1416011

ACE2
Angiotensin-converting enzyme 2

1

2

High-throughput

0.437

High

1416021

PKHA4
Pleckstrin homology domain-containing family A member 4

1

7

High-throughput

0.437

High

1416022

EGLN3
Prolyl hydroxylase EGLN3

1

1

High-throughput

0.437

High

1416035

ZRAN1
Ubiquitin thioesterase ZRANB1

1

3

High-throughput

0.437

High

1416038

XPO7
Exportin-7

1

2

High-throughput

0.437

High

1416040

ANC2
Anaphase-promoting complex subunit 2

1

7

High-throughput

0.437

High

294751

PR15A
Protein phosphatase 1 regulatory subunit 15A

1

0

High-throughput

0.426

High

73850

C1T9B
Complement C1q and tumor necrosis factor-related protein 9B

1

2

High-throughput

0.407

High

133308

P2Y10
Putative P2Y purinoceptor 10

1

3

High-throughput

0.407

High

240207

KLK8
Kallikrein-8

1

2

High-throughput

0.407

High

430317

JUN
Transcription factor Jun

1

8

High-throughput

0.407

High

479077

CEL3A
Chymotrypsin-like elastase family member 3A

1

1

High-throughput

0.407

High

600515

ZNF3
Zinc finger protein 3

1

1

High-throughput

0.407

High

1101652

GPR17
Uracil nucleotide/cysteinyl leukotriene receptor

1

2

High-throughput

0.407

High

1227383

A16L1
Autophagy-related protein 16-1

1

2

High-throughput

0.407

High

1271265

SV2B
Synaptic vesicle glycoprotein 2B

1

2

High-throughput

0.407

High

1416018

SPNS1
Protein spinster homolog 1

1

3

High-throughput

0.407

High

1416041

XCT
Cystine/glutamate transporter

1

1

High-throughput

0.407

High

253107

PLIN3
Perilipin-3

2

0

High-throughput

0.316

High

1139259

AR6P1
ADP-ribosylation factor-like protein 6-interacting protein 1

2

0

High-throughput

0.316

High

1158783

SYPL1
Synaptophysin-like protein 1

2

0

High-throughput

0.316

High

1416028

ASB6
Ankyrin repeat and SOCS box protein 6

2

0

High-throughput

0.316

High

1416031

TR10D
Tumor necrosis factor receptor superfamily member 10D

2

0

High-throughput

0.316

High

220194

TNF14
Tumor necrosis factor ligand superfamily member 14

1

0

High-throughput

0.279

Low

366437

FA12
Coagulation factor XII

1

0

High-throughput

0.279

Low

1158512

CDC37
Hsp90 co-chaperone Cdc37

1

0

High-throughput

0.279

Low

1384944

TRI43
Tripartite motif-containing protein 43

1

0

High-throughput

0.279

Low

1408275

PTN18
Tyrosine-protein phosphatase non-receptor type 18

1

0

High-throughput

0.279

Low

1411061

NAA38
N-alpha-acetyltransferase 38, NatC auxiliary subunit

1

0

High-throughput

0.279

Low

1416025

CT096
Uncharacterized protein C20orf96

1

0

High-throughput

0.279

Low

1416046

GPR45
Probable G-protein coupled receptor 45

1

0

High-throughput

0.279

Low

1357634

SFT2A
Vesicle transport protein SFT2A

1

0

High-throughput

0.268

Low

1380443

MAL2
Protein MAL2

1

0

High-throughput

0.268

Low

1386871

DDT4L
DNA damage-inducible transcript 4-like protein

1

0

High-throughput

0.268

Low

279475

TULP3
Tubby-related protein 3

1

0

High-throughput

0.249

Low

688305

TTP
mRNA decay activator protein ZFP36

1

0

High-throughput

0.249

Low

833355

PERI
Peripherin

1

0

High-throughput

0.249

Low

1126167

GRM2
Metabotropic glutamate receptor 2

1

0

High-throughput

0.249

Low

1233457

LTOR1
Ragulator complex protein LAMTOR1

1

0

High-throughput

0.249

Low

1252377

MEX3B
RNA-binding protein MEX3B

1

0

High-throughput

0.249

Low

1327171

FBXL6
F-box/LRR-repeat protein 6

1

0

High-throughput

0.249

Low

1332889

KDF1
Keratinocyte differentiation factor 1

1

0

High-throughput

0.249

Low

1415071

LRC61
Leucine-rich repeat-containing protein 61

1

0

High-throughput

0.249

Low

1416015

SPRTN
DNA-dependent metalloprotease SPRTN

1

0

High-throughput

0.249

Low

1416029

TLS1
Splicing factor C9orf78

1

0

High-throughput

0.249

Low

64906

RCCD1
RCC1 domain-containing protein 1

1

0

High-throughput

0.232

Low

844965

EAA2
Excitatory amino acid transporter 2

1

0

High-throughput

0.232

Low

1086183

CETN1
Centrin-1

1

0

High-throughput

0.232

Low

1324272

LYPD1
Ly6/PLAUR domain-containing protein 1

1

0

High-throughput

0.232

Low

1335704

MOT11
Monocarboxylate transporter 11

1

0

High-throughput

0.232

Low

1380526

PIGT
GPI-anchor transamidase component PIGT

1

0

High-throughput

0.232

Low


Service provided by Combinatics, Japan

Last updated: 11Aug2025