Interactor 1: ITB3 (P05106)
Integrin beta-3 (Platelet membrane glycoprotein IIIa) (GPIIIa) (CD antigen CD61)
Gene: ITGB3

Interactor 2: ITB3 (P05106)
Integrin beta-3 (Platelet membrane glycoprotein IIIa) (GPIIIa) (CD antigen CD61)
Gene: ITGB3

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score Annotation score Interaction score
0.71 1.00 0.843

The method score is based on:

Property Details
Experiments 22178926, 11606749, 14681217
Identification Methods pull down, comigration in non denaturing gel electrophoresis, cosedimentation in solution, lex-a dimerization assay
Interaction Type physical association, direct interaction

The annotation score is based on:

Property Details
Interacting Pfam domains EGF_2~Integrin_B_tail, I-EGF_1~PSI_integrin, Integrin_beta~Integrin_beta
Common GO terms GO:0001618 - virus receptor activity
GO:0001934 - positive regulation of protein phosphorylation
GO:0001938 - positive regulation of endothelial cell proliferation
GO:0001954 - positive regulation of cell-matrix adhesion
GO:0001968 - fibronectin binding
and 103 others

more...

Homologous interactions 14

Homologous interactions

Color coding for hit scores

1 788
Hs

1 788
+ Mm
+ Hs
+ Hs
+ Mm
+ Dm
+ Dm
+ Dm
+ Dm
+ Dm
+ Hs
+ Ss
+ Dr
+ Hs
+ Rn

Service provided by Combinatics, Japan

Last updated: 15 Jul 2024