Protein: PPHLN
Periphilin-1 (CDC7 expression repressor) (CR) (Gastric cancer antigen Ga50)

Gene: PPHLN, PPHLN1
Organism: Homo sapiens
Interactions: 148
UniProt ID: Q8NEY8

Gene Ontology (top 5):
GO:0003723 - RNA binding
GO:0005654 - nucleoplasm
GO:0005694 - chromosome
GO:0005794 - Golgi apparatus
GO:0005829 - cytosol

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

889615

CLK2
Dual specificity protein kinase CLK2

3

2

High-throughput

0.675

High

1292787

SKAP1
Src kinase-associated phosphoprotein 1

3

1

High-throughput

0.667

High

1290599

ZCH18
Zinc finger CCCH domain-containing protein 18

3

0

High-throughput

0.638

High

1338163

AP2M1
AP-2 complex subunit mu

3

0

High-throughput

0.638

High

889773

CLK3
Dual specificity protein kinase CLK3

2

2

High-throughput

0.628

High

1338153

HNRLL
Heterogeneous nuclear ribonucleoprotein L-like

2

1

High-throughput

0.628

High

1338175

NXF2
Nuclear RNA export factor 2

2

1

High-throughput

0.628

High

799310

BRCA1
Breast cancer type 1 susceptibility protein

2

1

High-throughput

0.614

High

1338194

LMBL1
Lethal(3)malignant brain tumor-like protein 1

2

0

High-throughput

0.602

High

900043

FXR1
RNA-binding protein FXR1

2

0

High-throughput

0.601

High

1016523

SRSF3
Serine/arginine-rich splicing factor 3

2

1

High-throughput

0.601

High

1049579

1433F
14-3-3 protein eta

2

1

High-throughput

0.601

High

1338168

MPP8
M-phase phosphoprotein 8

2

1

Small-scale

0.594

High

786734

PP1G
Serine/threonine-protein phosphatase PP1-gamma catalytic subunit

2

0

High-throughput

0.585

High

1015261

ERH
Enhancer of rudimentary homolog

2

0

High-throughput

0.576

High

396546

ESR1
Estrogen receptor

2

1

High-throughput

0.571

High

260192

BRD4
Bromodomain-containing protein 4

2

0

High-throughput

0.559

High

1338180

ANLN
Anillin

2

0

High-throughput

0.559

High

1338195

SNCAP
Synphilin-1

1

1

Small-scale

0.552

High

1338172

SHAN3
SH3 and multiple ankyrin repeat domains protein 3

1

1

High-throughput

0.541

High

74552

HNRC2
Heterogeneous nuclear ribonucleoprotein C-like 2

1

2

High-throughput

0.536

High

166543

BACH1
Transcription regulator protein BACH1

1

1

High-throughput

0.536

High

256648

HNRC1
Heterogeneous nuclear ribonucleoprotein C-like 1

1

2

High-throughput

0.536

High

344253

PTBP3
Polypyrimidine tract-binding protein 3

1

1

High-throughput

0.536

High

462520

HNRPC
Heterogeneous nuclear ribonucleoproteins C1/C2

1

4

High-throughput

0.536

High

478121

SNRPA
U1 small nuclear ribonucleoprotein A

1

2

High-throughput

0.536

High

1099444

SRSF6
Serine/arginine-rich splicing factor 6

1

1

High-throughput

0.536

High

1148733

RBMS2
RNA-binding motif, single-stranded-interacting protein 2

1

2

High-throughput

0.536

High

1168844

HNRL2
Heterogeneous nuclear ribonucleoprotein U-like protein 2

1

1

High-throughput

0.536

High

1338151

NEDD1
Protein NEDD1

1

1

High-throughput

0.536

High

1338183

BCLF1
Bcl-2-associated transcription factor 1

1

1

High-throughput

0.536

High

1338191

TR150
Thyroid hormone receptor-associated protein 3

1

1

High-throughput

0.536

High

1233919

Q6ICH2
single-stranded DNA cytosine deaminase

2

2

High-throughput

0.533

High

1025393

CDK6
Cyclin-dependent kinase 6

1

0

Small-scale

0.527

High

1338174

TSG10
Testis-specific gene 10 protein

1

1

High-throughput

0.523

High

192613

NUP42
Nucleoporin NUP42

1

0

High-throughput

0.513

High

542119

TOP1
DNA topoisomerase 1

1

0

High-throughput

0.513

High

592866

CBR1
Carbonyl reductase [NADPH] 1

1

0

High-throughput

0.513

High

613403

VINC
Vinculin

1

0

High-throughput

0.513

High

854171

KI67
Proliferation marker protein Ki-67

1

0

High-throughput

0.513

High

948560

APC15
Anaphase-promoting complex subunit 15

1

0

High-throughput

0.513

High

1009257

PRR3
Proline-rich protein 3

1

0

High-throughput

0.513

High

1013085

HMGN5
High mobility group nucleosome-binding domain-containing protein 5

1

0

High-throughput

0.513

High

1065310

SSRP1
FACT complex subunit SSRP1

1

0

High-throughput

0.513

High

1103004

CENPR
Centromere protein R

1

0

High-throughput

0.513

High

1122288

SCRIB
Protein scribble homolog

1

0

High-throughput

0.513

High

1124502

MAP7
Ensconsin

1

0

High-throughput

0.513

High

1160211

CPSF6
Cleavage and polyadenylation specificity factor subunit 6

1

0

High-throughput

0.513

High

1163072

H2B2E
Histone H2B type 2-E

1

0

High-throughput

0.513

High

1287859

MTA70
N(6)-adenosine-methyltransferase catalytic subunit METTL3

1

0

High-throughput

0.513

High

1338158

EZH1
Histone-lysine N-methyltransferase EZH1

1

0

High-throughput

0.513

High

1338164

PABP5
Polyadenylate-binding protein 5

1

0

High-throughput

0.513

High

1338179

CPAP
Centrosomal P4.1-associated protein

1

0

High-throughput

0.513

High

1338185

DAXX
Death domain-associated protein 6

1

0

High-throughput

0.513

High

1115564

ASPP2
Apoptosis-stimulating of p53 protein 2

1

1

High-throughput

0.508

High

1006565

SRPK2
SRSF protein kinase 2

1

3

High-throughput

0.501

High

474838

VIME
Vimentin

1

0

High-throughput

0.486

High

1060196

B2CL1
Bcl-2-like protein 1

1

0

High-throughput

0.486

High

1107941

SQSTM
Sequestosome-1

1

0

High-throughput

0.486

High

1158437

CDC37
Hsp90 co-chaperone Cdc37

1

0

High-throughput

0.486

High

1338159

UFD1
Ubiquitin recognition factor in ER-associated degradation protein 1

1

0

High-throughput

0.486

High

1338187

NAGK
N-acetyl-D-glucosamine kinase

1

0

High-throughput

0.486

High

1257079

PAXI1
PAX-interacting protein 1

1

1

High-throughput

0.481

High

1338154

TOPB1
DNA topoisomerase 2-binding protein 1

1

1

Small-scale

0.481

High

185865

OGT1
UDP-N-acetylglucosamine--peptide N-acetylglucosaminyltransferase 110 kDa subunit

1

0

High-throughput

0.480

High

422647

A4
Amyloid-beta precursor protein

1

0

High-throughput

0.480

High

908559

CASP5
Caspase-5

1

0

Small-scale

0.480

High

1338193

FBX7
F-box only protein 7

1

0

High-throughput

0.480

High

1338188

TASOR
Protein TASOR

1

0

Small-scale

0.479

High

331159

KI20A
Kinesin-like protein KIF20A

1

2

High-throughput

0.479

High

372619

MYC
Myc proto-oncogene protein

1

1

High-throughput

0.479

High

406407

MYCN
N-myc proto-oncogene protein

1

1

High-throughput

0.479

High

472904

RU17
U1 small nuclear ribonucleoprotein 70 kDa

1

1

High-throughput

0.479

High

846390

MATR3
Matrin-3

1

2

High-throughput

0.479

High

1035792

KIF23
Kinesin-like protein KIF23

1

1

High-throughput

0.479

High

1134995

CUL7
Cullin-7

1

1

High-throughput

0.479

High

1161554

IF16
Gamma-interferon-inducible protein 16

1

1

High-throughput

0.479

High

1235475

IFIX
Pyrin and HIN domain-containing protein 1

1

1

High-throughput

0.479

High

1310762

CUL9
Cullin-9

1

1

High-throughput

0.479

High

1311810

DHX40
Probable ATP-dependent RNA helicase DHX40

1

1

High-throughput

0.479

High

1314317

SLX4
Structure-specific endonuclease subunit SLX4

1

1

High-throughput

0.479

High

1338150

NUP43
Nucleoporin Nup43

1

1

High-throughput

0.479

High

1338157

ESR2
Estrogen receptor beta

1

1

High-throughput

0.479

High

1338165

SNX27
Sorting nexin-27

1

1

High-throughput

0.479

High

1338167

RANB9
Ran-binding protein 9

1

1

High-throughput

0.479

High

1338173

HOIL1
RanBP-type and C3HC4-type zinc finger-containing protein 1

1

1

High-throughput

0.479

High

1338184

NXF1
Nuclear RNA export factor 1

1

1

High-throughput

0.479

High

248743

PEPL
Periplakin

1

0

Small-scale

0.460

High

129264

MEN1
Menin

1

0

High-throughput

0.458

High

349165

LATS1
Serine/threonine-protein kinase LATS1

1

0

High-throughput

0.458

High

401169

RAF1
RAF proto-oncogene serine/threonine-protein kinase

1

0

High-throughput

0.458

High

485276

ROA1
Heterogeneous nuclear ribonucleoprotein A1

1

0

High-throughput

0.458

High

606925

CEBPB
CCAAT/enhancer-binding protein beta

1

0

High-throughput

0.458

High

765722

BMI1
Polycomb complex protein BMI-1

1

0

High-throughput

0.458

High

851613

GATA4
Transcription factor GATA-4

1

0

High-throughput

0.458

High

980014

H4
Histone H4

1

0

High-throughput

0.458

High

1045543

TF65
Transcription factor p65

1

0

High-throughput

0.458

High

1127016

RBM39
RNA-binding protein 39

1

0

High-throughput

0.458

High

1140585

KIF14
Kinesin-like protein KIF14

1

0

High-throughput

0.458

High

1152554

ELAV1
ELAV-like protein 1

1

0

High-throughput

0.458

High

1258296

MOB2
MOB kinase activator 2

1

0

High-throughput

0.458

High

1313272

SMC5
Structural maintenance of chromosomes protein 5

1

0

High-throughput

0.458

High

1338152

DOT1L
Histone-lysine N-methyltransferase, H3 lysine-79 specific

1

0

High-throughput

0.458

High

1338162

CHM4C
Charged multivesicular body protein 4c

1

0

High-throughput

0.458

High

1338169

ANM1
Protein arginine N-methyltransferase 1

1

0

High-throughput

0.458

High

1338171

DDX23
Probable ATP-dependent RNA helicase DDX23

1

0

High-throughput

0.458

High

1338176

XRN2
5'-3' exoribonuclease 2

1

0

High-throughput

0.458

High

1338182

NLE1
Notchless protein homolog 1

1

0

High-throughput

0.458

High

1338186

ZRAN1
Ubiquitin thioesterase ZRANB1

1

0

High-throughput

0.458

High

889464

CLK1
Dual specificity protein kinase CLK1

1

2

High-throughput

0.457

High

966639

1433G
14-3-3 protein gamma

1

1

High-throughput

0.445

High

1226185

CP135
Centrosomal protein of 135 kDa

1

1

High-throughput

0.445

High

1338156

PRP16
Pre-mRNA-splicing factor ATP-dependent RNA helicase PRP16

1

1

High-throughput

0.445

High

1338160

ABC3D
DNA dC->dU-editing enzyme APOBEC-3D

1

2

High-throughput

0.445

High

1338177

ATG5
Autophagy protein 5

1

0

Small-scale

0.438

High

480232

RU1C
U1 small nuclear ribonucleoprotein C

1

0

High-throughput

0.426

High

485687

RU2A
U2 small nuclear ribonucleoprotein A'

1

0

High-throughput

0.426

High

574381

RSMB
Small nuclear ribonucleoprotein-associated proteins B and B'

1

0

High-throughput

0.426

High

658288

RS3
Small ribosomal subunit protein uS3

1

0

High-throughput

0.426

High

860846

RS10
Small ribosomal subunit protein eS10

1

0

High-throughput

0.426

High

1338192

LC7L2
Putative RNA-binding protein Luc7-like 2

1

0

High-throughput

0.426

High

73426

B2CML4
single-stranded DNA cytosine deaminase

1

2

High-throughput

0.407

High

1338166

ZN597
Zinc finger protein 597

4

0

High-throughput

0.360

High

244739

ZC3H1
Zinc finger C3H1 domain-containing protein

2

0

High-throughput

0.328

High

1063816

LG3BP
Galectin-3-binding protein

2

0

High-throughput

0.328

High

1180404

KLH40
Kelch-like protein 40

2

0

High-throughput

0.328

High

1278543

P4HA3
Prolyl 4-hydroxylase subunit alpha-3

2

0

High-throughput

0.328

High

1179989

CCD57
Coiled-coil domain-containing protein 57

1

0

High-throughput

0.299

High

1205888

MTUS2
Microtubule-associated tumor suppressor candidate 2

1

0

High-throughput

0.299

High

1338170

SH3G3
Endophilin-A3

2

0

High-throughput

0.298

High

1147642

TOM20
Mitochondrial import receptor subunit TOM20 homolog

1

0

High-throughput

0.282

High

1338189

ITBP2
Integrin beta-1-binding protein 2

1

0

High-throughput

0.282

High

488065

IFI6
Interferon alpha-inducible protein 6

1

0

High-throughput

0.279

Low

515890

SAA1
Serum amyloid A-1 protein

1

0

High-throughput

0.279

Low

935769

MFAP4
Microfibril-associated glycoprotein 4

1

0

High-throughput

0.279

Low

1092791

MALL
MAL-like protein

1

0

High-throughput

0.279

Low

1093760

GAGE5
G antigen 5

1

0

High-throughput

0.279

Low

1218112

CP141
Cilia- and flagella-associated protein 141

1

0

High-throughput

0.279

Low

1253906

FA83H
Protein FAM83H

1

0

High-throughput

0.279

Low

1294345

ZN677
Zinc finger protein 677

1

0

High-throughput

0.279

Low

1338161

RGMA
Repulsive guidance molecule A

1

0

High-throughput

0.279

Low

1338181

TM14B
Transmembrane protein 14B

1

0

High-throughput

0.279

Low

1338190

ANR50
Ankyrin repeat domain-containing protein 50

1

0

High-throughput

0.279

Low

1338155

SEPT8
Septin-8

1

0

High-throughput

0.265

Low

1132682

GRM7
Metabotropic glutamate receptor 7

1

0

High-throughput

0.249

Low

1254713

TRI67
Tripartite motif-containing protein 67

1

0

High-throughput

0.249

Low

1276503

PARPT
Protein mono-ADP-ribosyltransferase TIPARP

1

0

High-throughput

0.249

Low

1338178

PKHA4
Pleckstrin homology domain-containing family A member 4

1

0

High-throughput

0.249

Low


Service provided by Combinatics, Japan

Last updated: 11Aug2025